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Toward a Smartphone-Based and Conversational Agent–Delivered Just-in-Time Adaptive Holistic Lifestyle Intervention for Older Adults Affected by Cognitive Decline: Two-Week Proof-of-Concept Study

Toward a Smartphone-Based and Conversational Agent–Delivered Just-in-Time Adaptive Holistic Lifestyle Intervention for Older Adults Affected by Cognitive Decline: Two-Week Proof-of-Concept Study

Dementia is expected to become one of the most critical global health challenges, with an estimated prevalence of 152 million patients worldwide by 2050 [1]. The neurodegenerative cascade in dementia commences well before clinically significant symptoms appear and can be conceptualized as a continuum extending from subjective cognitive decline (SCD) in the preclinical phase to mild cognitive impairment (MCI) to more advanced stages of the disease [2].

Esther Brill, Rasita Vinay, Marcia Nißen, Priyam Joshi, Stefan Klöppel, Tobias Kowatsch

JMIR Form Res 2025;9:e66885

Creating User Personas to Represent the Needs of Dementia Caregivers Who Support Medication Management at Home: Persona Development and Qualitative Study

Creating User Personas to Represent the Needs of Dementia Caregivers Who Support Medication Management at Home: Persona Development and Qualitative Study

Qualities of the care recipient include the stage and symptoms of dementia [8] and any co-occurring medical conditions [6], both of which may change over time, in turn, prompting changes to their medication routine [26,27]. Caregivers vary in their health literacy, access to information, commitment to self-care, and valuing of the care recipient’s independence [28], all of which may affect how they manage medication.

Anna Jolliff, Priya Loganathar, Richard J Holden, Anna Linden, Himalaya Patel, Jessica R Lee, Aaron Ganci, Noll Campbell, Malaz Boustani, Nicole E Werner

JMIR Aging 2025;8:e63944

Usability and Impact of the Web-Based Dementia Foundations Educational Program in Personal Support Workers (PSWs), PSW Trainees, and Care Companions: Quasi-Experimental Study

Usability and Impact of the Web-Based Dementia Foundations Educational Program in Personal Support Workers (PSWs), PSW Trainees, and Care Companions: Quasi-Experimental Study

PSWs have indicated that more training is needed, specifically in the field of dementia and mental health [8]. With over 69% of residents in long-term care (LTC) homes living with dementia and 87% with some form of cognitive impairment [9], more specific education and training about dementia are needed for PSWs. There are currently a variety of training approaches for dementia for unregulated care providers.

Anthony J Levinson, Stephanie Ayers, Sandra Clark, Patricia Gerantonis, Amy Schneeberg, Richard Sztramko

JMIR Aging 2025;8:e67889

Exploring the Immediate and Long-Term Effects of Immersive Virtual Reality on Behavioral and Psychological Symptoms of Dementia and Caregiver Burden: Longitudinal Observational Study

Exploring the Immediate and Long-Term Effects of Immersive Virtual Reality on Behavioral and Psychological Symptoms of Dementia and Caregiver Burden: Longitudinal Observational Study

Over the past few decades, the rapid growth of the older adults population in high-income countries has led to a continuous rise in the prevalence of dementia, posing significant social and economic impacts [1]. Globally, more than 50 million people are estimated to have dementia, and this number continues to rise [2,3].

Ling-Chun Huang, Ching-Fang Chien, Yuan-Han Yang

JMIR Serious Games 2025;13:e73044

Multimodal Detection of Agitation in People With Dementia in Clinical Settings: Observational Pilot Study

Multimodal Detection of Agitation in People With Dementia in Clinical Settings: Observational Pilot Study

Dementia is a neurodegenerative condition that leads to a progressive decline in cognition and is one of the leading causes of death, disability, and hospitalization in Canada and worldwide. Currently, dementia is the seventh cause of death worldwide [1]. Worldwide, over 55 million individuals are living with dementia; as the ratio of older people increases, this number will grow to 78 million by 2030 and 139 million by 2050, making dementia a major global health crisis [1].

Abeer Badawi, Somayya Elmoghazy, Samira Choudhury, Sara Elgazzar, Khalid Elgazzar, Amer M Burhan

JMIR Aging 2025;8:e68156

Acceptability of a Web-Based Financial Education Intervention for Latino Caregivers: Mixed Methods Evaluation

Acceptability of a Web-Based Financial Education Intervention for Latino Caregivers: Mixed Methods Evaluation

Demographic characteristics of Latino caregivers of persons living with dementia (n=14) who participated in qualitative interviews following the CONFIDENCEa intervention. a CONFIDENCE: Confidently Navigating Financial Decisions and Enhancing Financial Well-Being in Dementia Caregiving. b FPL: federal poverty level. c Missing data.

Susanna Mage, Donna Benton, Kathleen Wilber, Rocio Aguila Rodriguez, David Silva, Alexander Gonzalez, Frank Puga, Kylie Meyer

JMIR Form Res 2025;9:e70471

GamePlan4Care, a Web-Based Adaptation of the Resources for Enhancing Alzheimer’s Caregiver Health II Intervention for Family Caregivers of Persons Living With Dementia: Formative, Qualitative Usability Testing Study

GamePlan4Care, a Web-Based Adaptation of the Resources for Enhancing Alzheimer’s Caregiver Health II Intervention for Family Caregivers of Persons Living With Dementia: Formative, Qualitative Usability Testing Study

Communities across the United States are challenged to meet the physical, emotional, and social needs of persons living with dementia. Currently, nearly 7 million Americans are living with dementia, and that number is expected to almost double in the next 25 years [1].

Jinmyoung Cho, Thomas Birchfield, Jennifer L Thorud, Marcia G Ory, Alan B Stevens

JMIR Form Res 2025;9:e60143

Quantitative Research on Digitalized Treatment Options for Older Adults With Mental Illness: Scoping Review

Quantitative Research on Digitalized Treatment Options for Older Adults With Mental Illness: Scoping Review

These interventions were based on the assumption that playing and listening to music via digital devices would have a positive effect on people with dementia. A total of 40% (2/5) of the studies found that listening to music was associated with decreased agitation and apathy among people with dementia [65,81].

Jennifer Anne Stanford, Sandra Anna Just

JMIR Ment Health 2025;12:e70321

Design of a Mobile App and a Clinical Trial Management System for Cognitive Health and Dementia Risk Reduction: User-Centered Design Approach

Design of a Mobile App and a Clinical Trial Management System for Cognitive Health and Dementia Risk Reduction: User-Centered Design Approach

The rising prevalence of dementia, driven by sociodemographic changes, constitutes a significant global health challenge. Projections indicate a notable rise from 57 million affected individuals in 2019 to an anticipated 153 million by 2050 [1]. Notably, the Lancet Commission’s report underscores that approximately 45% of all cases of dementia are associated with 14 potentially modifiable risk factors at different phases of the life span [2], and diet has also been suggested as an additional factor [3].

Hannes Hilberger, Bianca Buchgraber-Schnalzer, Simone Huber, Theresa Weitlaner, Markus Bödenler, Alara Abaci, Jeroen Bruinsma, Ana Diaz, Anna Giulia Guazzarini, Jenni Lehtisalo, Seungjune Lee, Vasileios Loukas, Francesca Mangialasche, Patrizia Mecocci, Tiia Ngandu, Anna Rosenberg, Elisabeth Stögmann, Konsta Valkonen, Elena Uhlik, Helena Untersteiner, Laura Kneß, Helmut Ahammer, Sten Hanke

JMIR Aging 2025;8:e66660

The Rapid Online Cognitive Assessment for the Detection of Neurocognitive Disorder: Open-Label Study

The Rapid Online Cognitive Assessment for the Detection of Neurocognitive Disorder: Open-Label Study

Current projections estimate 150 million patients with dementia worldwide by 2050, with 57 million as of 2019 [1]. This causes considerable health care system strain, leaving a majority of patients undiagnosed [2-5]. However, for the patients who do receive a diagnosis, it often takes 3 years or longer from symptom onset [2,3,6-8]. The next step, that is, receiving an etiological diagnosis like Alzheimer disease, requires even more time [4,8].

Calvin Howard, Amy Johnson, Joseph Peedicail, Marcus C Ng

J Med Internet Res 2025;27:e66735