TY  - JOUR
AU  - Hilberger, Hannes
AU  - Buchgraber-Schnalzer, Bianca
AU  - Huber, Simone
AU  - Weitlaner, Theresa
AU  - Bödenler, Markus
AU  - Abaci, Alara
AU  - Bruinsma, Jeroen
AU  - Diaz, Ana
AU  - Guazzarini, Anna Giulia
AU  - Lehtisalo, Jenni
AU  - Lee, Seungjune
AU  - Loukas, Vasileios
AU  - Mangialasche, Francesca
AU  - Mecocci, Patrizia
AU  - Ngandu, Tiia
AU  - Rosenberg, Anna
AU  - Stögmann, Elisabeth
AU  - Valkonen, Konsta
AU  - Uhlik, Elena
AU  - Untersteiner, Helena
AU  - Kneß, Laura
AU  - Ahammer, Helmut
AU  - Hanke, Sten
PY  - 2025
DA  - 2025/7/2
TI  - Design of a Mobile App and a Clinical Trial Management System for Cognitive Health and Dementia Risk Reduction: User-Centered Design Approach
JO  - JMIR Aging
SP  - e66660
VL  - 8
KW  - clinical trial
KW  - medical informatics
KW  - health information systems
KW  - eHealth
KW  - mobile health
KW  - mHealth
KW  - mobile apps
KW  - dementia
KW  - cognitive decline
KW  - prevention
KW  - multidomain interventions
KW  - artificial intelligence
KW  - AI
AB  - Background: The rising prevalence of dementia is a major concern, with approximately 45% of cases linked to 14 modifiable risk factors. The European project LETHE aims to develop a personalized digital intervention model to delay or prevent cognitive decline through risk factor management. Objective: The objective of our study was to design a clinical trial platform for older individuals at risk of cognitive decline, including a mobile app for study participants and a clinical trial management system (CTMS) for health professionals. Methods: Using a user-centered design approach, workshops and feedback rounds involved potential participants representing the target group and professionals. The LETHE app’s usability was assessed among 156 older adults enrolled in a 2-year multinational randomized controlled trial evaluating the feasibility of a digitally supported lifestyle program for dementia risk reduction. The randomized controlled trial is currently ongoing; the System Usability Scale (SUS) was administered 1 month after baseline to map first user experiences. Feedback on the LETHE CTMS was collected from 21 users. Results: Of the 78 participants in the trial intervention group, 66 (85%) provided responses for the mobile app, with a median SUS score of 70 (IQR 55-82). Within the control group, 73% (57/78) of responses were received, with a median SUS score of 73 (IQR 63-90). For the CTMS, we received 71% (15/21) of responses, and the feedback was mostly positive. A ranking of the features that could be considered beyond state of the art showed that the integration of personalized activities (mean 2.23, SD 1.17) and real-time appointments (mean 2.46, SD 1.51) were considered the most novel ones. Conclusions: The LETHE app and CTMS were developed to support a personalized digital intervention method within a study involving 156 participants. Limitations include participants having digital literacy and internet access, potentially impacting the generalizability of the findings. Despite these limitations, positive feedback and high usability scores suggest promising potential for the LETHE app and CTMS in supporting personalized interventions to prevent cognitive decline in older adults. 
SN  - 2561-7605
UR  - https://aging.jmir.org/2025/1/e66660
UR  - https://doi.org/10.2196/66660
DO  - 10.2196/66660
ID  - info:doi/10.2196/66660
ER  -