Integrated High-Throughput Targeted Metabolomics and Machine Learning for Early Prediction and Prevention of Postoperative Delirium in Older Adult Surgical Patients: Prospective Multicenter Cohort Study

Gengrui Zhong   ^{1 *} , MD ;   Xiaoli Huang   ^{2 *} , MD ;   Congye Li   ¹ , MD ;   Deqiang Wang   ³ , MD ;   Dingding Huang   ⁴ , MD ;   Menghan Sun   ⁵ , MD ;   Quanhong Zhou   ¹ , MD, PhD ;   Yong Guo   ¹ , MD, PhD

¹ Department of Critical Care Medicine, The Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

² Department of Critical Care Medicine, Jinshan District Central Hospital, Shanghai, China

³ Department of Critical Care Medicine, Fengxian District Central Hospital, Shanghai, China

⁴ Department of Anesthesiology, Fengxian District Central Hospital, Shanghai, China

⁵ Department of Critical Care Medicine, Shanghai Eighth People's Hospital, Shanghai, China

*these authors contributed equally