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Sodium Oxybate as a Potential New Treatment for Catatonia in Patients With Depression, Bipolar Disorder, or a Psychotic Disorder: Protocol for a Randomized Controlled Trial

Sodium Oxybate as a Potential New Treatment for Catatonia in Patients With Depression, Bipolar Disorder, or a Psychotic Disorder: Protocol for a Randomized Controlled Trial

Sodium oxybate, the pharmacological agent used in this study, acts as a GABA-B receptor agonist and a precursor of GABA [24]. It was administered in doses ranging between 0.01 and 0.1 g/kg, 3 times daily either orally or intravenously (equivalent to 2.4-24 g/d for an 80 kg patient). Among patients with schizophrenia and catatonia, approximately 30 participants, the study showed a reduction of catatonic symptoms ranging from 60% to 70%.

Lilian Bot, Josine G van Mill, Laetitia J C A Smarius, Adriaan W Hoogendoorn, Bram W C Storosum, Christiaan H Vinkers, Gabriel E Jacobs, Gert Jan Lammers, Hanna M Heller, Jantine C A Colen-de Koning, Joris J B van der Vlugt, Marloes S Oudijn, Martijn S van Noorden, Pierre M Bet, Rolf Fronczek, Heleen S van der Heijden, Sjors M M Lange, Ysbrand D van der Werf, Eric R van Exel

JMIR Res Protoc 2025;14:e68356

Associations Between Daily Symptoms and Pain Flares in Rheumatoid Arthritis: Case-Crossover mHealth Study

Associations Between Daily Symptoms and Pain Flares in Rheumatoid Arthritis: Case-Crossover mHealth Study

(B) Two scenarios of exclusion. Left: the onset (day 4) meets the definition, but the pain severity is at the personal median pain level, conflicting with the criterion for the end of a pain flare. Right: 2 flare onsets (days 2 and 4) meet the definition but end on the same day (day 5). The second onset (day 4) is removed to avoid double counting. In addition to identifying pain flares by their severity, we examined their residual impact in the postflare phase.

Ting-Chen Chloe Hsu, Belay B Yimer, Pauline Whelan, Christopher J Armitage, Katie Druce, John McBeth

JMIR Mhealth Uhealth 2025;13:e64889

Multimodal Detection of Agitation in People With Dementia in Clinical Settings: Observational Pilot Study

Multimodal Detection of Agitation in People With Dementia in Clinical Settings: Observational Pilot Study

This study was approved by the Joint Research Ethics Board (JREB) at Ontario Shores Centre for Mental Health Sciences and Ontario Tech University (JREB Number: 21-011-B). Informed consent was obtained from all participants’ substitute decision makers, as the participants had advanced dementia and were unable to provide consent themselves.

Abeer Badawi, Somayya Elmoghazy, Samira Choudhury, Sara Elgazzar, Khalid Elgazzar, Amer M Burhan

JMIR Aging 2025;8:e68156

AI Predictive Model of Mortality and Intensive Care Unit Admission in the COVID-19 Pandemic: Retrospective Population Cohort Study of 12,000 Patients

AI Predictive Model of Mortality and Intensive Care Unit Admission in the COVID-19 Pandemic: Retrospective Population Cohort Study of 12,000 Patients

(A) Mortality predictor model and (B) ICU admission predictor metrics. AUC: area under the receiver operating characteristic curve; TNR: true negative rate; TPR: true positive rate. Global predictors ROCs for mortality and ICU admissions. Model validation using new records confirms the performance of the global models. With validation hospitalized dataset, the exitus global model has a sensitivity of 0.86, specificity of 0.74, PPV of 0.24 (18/79), NPV of 0.98 (160/163), and AUC of 0.85.

Jose Manuel Ruiz Giardin, Óscar Garnica, Nieves Mesa Plaza, Juan Víctor SanMartín López, Ana Farfán Sedano, Elena Madroñal Cerezo, Miguel Ángel Duarte Millán, Aida Izquierdo Martínez, Luis Rivas, Marta Rivilla, Alejandro Morales Ortega, Begoña Frutos Pérez, Cristina De Ancos Aracil, Ruth Calderón, Guillermo Soria Fernandez, Jorge Marrero Francés, David Bernal Bello, Jose Ángel Satué Bartolomé, María Toledano Macías, Sara Piedrabuena García, Marta Guerrero Santillán, Rafael Cristóbal, Belen Mora, Laura Velázquez Ríos, Vanesa García de Viedma, Paula Cuenca Ruiz, Ibone Ayala Larrañaga, Lorena Carpintero, Celia Lara, Alvaro Ricardo Llerena, Virginia García Bermúdez, Gema Delgado Cárdenas, Paloma Pardo Rovira, Elena Tejero Sánchez, Maria Jesús Domínguez García, Carolina Mariño, Cristina Bravo, Ana Ontañon, Mario García, Jose Ignacio Hidalgo Pérez, Santiago Prieto Menchero, Natalia González Pereira, Sonia Gonzalo Pascua, Jorge Tarancón Rey, Luis Antonio Lechuga Suárez, FUENCOVID

J Med Internet Res 2025;27:e70674