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Sodium oxybate, the pharmacological agent used in this study, acts as a GABA-B receptor agonist and a precursor of GABA [24]. It was administered in doses ranging between 0.01 and 0.1 g/kg, 3 times daily either orally or intravenously (equivalent to 2.4-24 g/d for an 80 kg patient). Among patients with schizophrenia and catatonia, approximately 30 participants, the study showed a reduction of catatonic symptoms ranging from 60% to 70%.
JMIR Res Protoc 2025;14:e68356
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(B) Two scenarios of exclusion. Left: the onset (day 4) meets the definition, but the pain severity is at the personal median pain level, conflicting with the criterion for the end of a pain flare. Right: 2 flare onsets (days 2 and 4) meet the definition but end on the same day (day 5). The second onset (day 4) is removed to avoid double counting.
In addition to identifying pain flares by their severity, we examined their residual impact in the postflare phase.
JMIR Mhealth Uhealth 2025;13:e64889
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This study was approved by the Joint Research Ethics Board (JREB) at Ontario Shores Centre for Mental Health Sciences and Ontario Tech University (JREB Number: 21-011-B). Informed consent was obtained from all participants’ substitute decision makers, as the participants had advanced dementia and were unable to provide consent themselves.
JMIR Aging 2025;8:e68156
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Conversational Systems for Social Care in Older Adults: Protocol for a Scoping Review
JMIR Res Protoc 2025;14:e72310
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(A) Mortality predictor model and (B) ICU admission predictor metrics. AUC: area under the receiver operating characteristic curve; TNR: true negative rate; TPR: true positive rate.
Global predictors ROCs for mortality and ICU admissions.
Model validation using new records confirms the performance of the global models. With validation hospitalized dataset, the exitus global model has a sensitivity of 0.86, specificity of 0.74, PPV of 0.24 (18/79), NPV of 0.98 (160/163), and AUC of 0.85.
J Med Internet Res 2025;27:e70674
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