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Evaluating the Accuracy of Web-Based and In-Clinic Subjective Cognitive Decline Assessments in Detecting Cognitive Impairment: Multicohort Study

Consequently, identifying individuals likely to have mild cognitive impairment (MCI)—potential candidates for disease-modifying therapy—has become increasingly important. Neuropsychological tests are widely used as diagnostic tools for cognitive impairment (CI), differentiating between individuals who are cognitively unimpaired (CU), those with MCI, and those with dementia [3].

Jae Myeong Kang, Manchumad Manjavong, Adam Diaz, Miriam T Ashford, Anna Aaronson, Joseph Eichenbaum, Scott Mackin, Rachana Tank, Melanie J Miller, Bernard Landavazo, Erika Cavallone, Diana Truran, Monica R Camacho, Juliet Fockler, Derek Flenniken, Sarah Tomaszewski Farias, Michael W Weiner, Rachel Nosheny

J Med Internet Res 2025;27:e69689

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Bridging Data Gaps in Emergency Care: The NIGHTINGALE Project and the Future of AI in Mass Casualty Management

Building on existing knowledge, this viewpoint paper draws on insights from the NIGHTINGALE project to offer recommendations for enhancing the role of AI in supporting MCI responses in prehospital settings, in the attempt to bridge the current data gaps. The NIGHTINGALE toolkit includes a wide range of tools, services, and applications designed to enhance triage during MCIs, optimize the use of resources, and facilitate coordinated responses among different stakeholders [15,16].

The NIGHTINGALE Consortium, Marta Caviglia

J Med Internet Res 2025;27:e67318

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Tablet- and Group-Based Multicomponent Cognitive Stimulation for Older Adults With Mild Cognitive Impairment: Single-Group Pilot Study and Protocol for Randomized Controlled Trial

Mild cognitive impairment (MCI) is the stage between normal aging and dementia, including probable Alzheimer disease, characterized by noticeable cognitive deficits that do not impair daily functioning significantly [1-3]. The cognitive domains affected by MCI include learning and memory, language, visuospatial abilities, executive functions, and psychomotor skills. Notably, evident impairment in any of these domains is sufficient for an MCI diagnosis [4].

Khanitin Jornkokgoud, Pattrawadee Makmee, Peera Wongupparaj, Alessandro Grecucci

JMIR Res Protoc 2025;14:e64465

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Association of Subjective Cognitive Concerns With Performance on Mobile App–Based Cognitive Assessment in Cognitively Normal Older Adults: Observational Study

Reference 15: Progression of subjective cognitive decline to MCI or Dementia in relation to biomarkers Cognitive lapses reported by daily digital diary, and not by recall‐based questionnaires, predict future MCImci

Caroline O Nester, Alyssa N De Vito, Sarah Prieto, Zachary J Kunicki, Jennifer Strenger, Karra D Harrington, Nelson Roque, Martin J Sliwinski, Laura A Rabin, Louisa I Thompson

JMIR Aging 2025;8:e64033

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The Needs and Experiences of People With Early-Stage Dementia Using an Application for Cognitive and Physical Activation in Germany: Qualitative Study

mci

Melina Klein, Alexa von Bosse, Christophe Kunze

JMIR Aging 2024;7:e62689

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A Multivariable Prediction Model for Mild Cognitive Impairment and Dementia: Algorithm Development and Validation

Mild cognitive impairment (MCI) is the transitional phase between normal aging and dementia [1]. According to a systematic review of global prevalence, MCI is estimated to affect approximately 15.56% of community-dwelling adults aged 50 years and older [2]. The annual progression rate of MCI to dementia, which is characterized by acquired memory loss that interferes with daily functioning [3], is believed to range from 12% to 17% [1].

Sarah Soyeon Oh, Bada Kang, Dahye Hong, Jennifer Ivy Kim, Hyewon Jeong, Jinyeop Song, Minkyu Jeon

JMIR Med Inform 2024;12:e59396

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Investigating Acoustic and Psycholinguistic Predictors of Cognitive Impairment in Older Adults: Modeling Study

It is estimated that approximately one-third of adults aged 65 years and older in the United States have mild cognitive impairment (MCI) or dementia [1]. Given the high prevalence of MCI and dementia, better methods are needed for earlier identification. Biomarkers associated with future cognitive decline can be evident decades before the deficits are clinically detected [2].

Varsha D Badal, Jenna M Reinen, Elizabeth W Twamley, Ellen E Lee, Robert P Fellows, Erhan Bilal, Colin A Depp

JMIR Aging 2024;7:e54655

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The Dual Task Ball Balancing Test and Its Association With Cognitive Function: Algorithm Development and Validation

Individuals with mild cognitive impairment (MCI) and higher cognitive reserve can delay the development of dementia. Thus, assessment of cognitive reserve is important to predict an individual’s functional state and prognosis. In addition, cognitive reserve can be a powerful therapeutic target, as increasing cognitive reserve might reduce disability.

Barry Greene, Sean Tobyne, Ali Jannati, Killian McManus, Joyce Gomes Osman, Russell Banks, Ranjit Kher, John Showalter, David Bates, Alvaro Pascual-Leone