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Leveraging Cognitive and Speech Ecological Momentary Assessment in Individuals With Phenylketonuria: Development and Usability Study of Cognitive Fluctuations in a Rare Disease Population

Leveraging Cognitive and Speech Ecological Momentary Assessment in Individuals With Phenylketonuria: Development and Usability Study of Cognitive Fluctuations in a Rare Disease Population

A brief description of the tests used are below, with further detailed information and psychometric characteristics described in Germine et al [38] and Singh et al [28]. In digit symbol matching (DSM) [22,26,39], participants are presented with 6 symbols, each of which are paired with a single digit between 1 and 3 (ie, 2 symbols were paired with each digit). These pairings remain visible throughout the duration of the test.

Shifali Singh, Lisa Kluen, Katelin Curtis, Raquel Norel, Carla Agurto, Elizabeth Grinspoon, Zoe Hawks, Shawn Christ, Susan Waisbren, Guillermo Cecchi, Laura Germine

JMIR Form Res 2025;9:e63644