Accepted for/Published in: JMIR Aging

Date Submitted:

Open Peer Review Period: -

Date Accepted:

Date Submitted to PubMed:

closed for review but you can still tweet
  • Xilin P, Ruihao Z, Xudong C, Fanfan S, Tao Z, Guo C
  • Exploring Risk Factors Related to Low Calf Circumference in Older Adults With Multimorbidity: Cross-Sectional Latent Class Analysis
  • JMIR Aging
  • DOI: 10.2196/11848
  • PMID: 30303485
  • PMCID: 6352016
Preprints Accepted Manuscript

Exploring Risk Factors Related to Low Calf Circumference in Older Adults With Multimorbidity: Cross-Sectional Latent Class Analysis

Abstract

background

As the global population continues to age, the prevalence of sarcopenia is gradually increasing, and the loss of skeletal muscle mass is one of the manifestations of sarcopenia. Low calf circumference is often used as a predictor of poor skeletal muscle mass or sarcopenia. The older adults usually have a combination of multiple chronic diseases. There is a lack of evidence to explore the risk factors for low calf circumference with multimorbidity in Chinese community-dwelling older adults.

objective

This study aimed to explore the risk factors and potential categories in low calf circumference with multimorbidity older adult patients from an individual-centered perspective.

methods

We selected 15,874 participants from the Chinese Longitudinal Healthy Longevity Survey in 2018 and screened for low calf circumference older adult patients. The "individual-centered" latent class analysis to classify potential multimorbidity groups. Applying elastic net to screen the reliable risk variables, multiple logistic regression was used to explore the risk factors in low calf circumference with multimorbidity.

results

A collection of 7956 older individuals was eligible for the research, with age over 90 years accounting for 3960(49.8%), 2166(27.2%) with multimorbidity in low calf circumference. Between 65 and 89 years of age, the prevalence of multimorbidity increased with age. However, the majority of older adults are in reasonably good health after the age of 90. Five multimorbidity groups were identified by latent class analysis: multisystem morbidity diseases (3.6%), arthritis-rheumatism or rheumatoid diseases (18.5%), diabetes-hypertension diseases (15.2%), respiratory-heart diseases (16.0%), and cardiovascular diseases (46.7%). Through 12 variables screened by elastic net, multiple logistic regression showed different significant impaction to multimorbidity groups, including demographic background, behavioural characteristics, and physical and mental health factors. In particular, older patients who self-report poor health grading and live in urban areas need more attention.

conclusions

ur results revealed that low calf circumference is a common phenomenon among older adults in the community-dwelling older adults, and combined multimorbidity is also a large group. In the low calf circumference older adult population, the proportion of multimorbidity does not simply increase with age. Multimorbidity in low calf circumference has been identified in five potential groups. Different groups have distinctive risk factors. Public health authorities should pay attention to the low calf circumference in older adult patients with multimorbidity, carrying out targeted interventions and enhancing health outcomes.

As per the author’s request the PDF is not available.
Copyright

© The authors. All rights reserved. This is a privileged document currently under peer-review/community review (or an accepted/rejected manuscript). Authors have provided JMIR Publications with an exclusive license to publish this preprint on it’s website for review and ahead-of-print citation purposes only. While the final peer-reviewed paper may be licensed under a cc-by license on publication, at this stage authors and publisher expressively prohibit redistribution of this draft paper other than for review purposes.

Citation

Please cite as:

Xilin P, Ruihao Z, Xudong C, Fanfan S, Tao Z, Guo C

Exploring Risk Factors Related to Low Calf Circumference in Older Adults With Multimorbidity: Cross-Sectional Latent Class Analysis

JMIR Aging

DOI: 10.2196/14886

URL: https://preprints.jmir.org/preprint/11848

PMID: 31789598

PMCID: 6352016

Exploring Risk Factors Related to Low Calf Circumference in Older Adults With Multimorbidity: Cross-Sectional Latent Class Analysis

Current Preprint Settings

(as selected by the authors)

  1. Allow access to the preprint PDF upon submission to:

    (a) Open peer-review purposes

    (b) Logged-in users only

    (c) Anybody, anytime

    (d) Nobody

  2. When the manuscript is accepted, display the accepted manuscript PDF to:

    (a) Logged-in users only

    (b) Anybody, anytime

    (c) Anybody, anytime, and the author has chosen to deposit the ahead-of-print metadata to PubMed

    (d) Nobody

  3. When a final paper is published in a JMIR journal, display the preprint as follows:

    (a) Allow download

    (b) Show abstract only

    (c) Do not display anything

  4. If the paper is rejected from JMIR journals, display the preprint to:

    (a) Logged-in users only

    (b) Anybody, anytime

    (c) Nobody