Published on in Vol 8 (2025)

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/66031, first published .
Sarcopenia and Risk of Cognitive Impairment: Cohort Study and Mendelian Randomization Analysis

Sarcopenia and Risk of Cognitive Impairment: Cohort Study and Mendelian Randomization Analysis

Sarcopenia and Risk of Cognitive Impairment: Cohort Study and Mendelian Randomization Analysis

Tingting Sha   1, 2, 3 , PhD ;   Yuqing Zhang   4, 5 , DSc ;   Jie Wei   1, 2, 3, 6, 7 , PhD ;   Changjun Li   3, 6, 8 , MD, PhD ;   Chao Zeng   1, 2, 3, 6, 7 , MD, PhD ;   Guanghua Lei   1, 2, 3, 6 , MD, PhD ;   Yilun Wang   1, 2, 3 , MD, PhD

1 Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China

2 Hunan Key Laboratory of Joint Degeneration and Injury, Changsha, China

3 Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment of Ministry of Education, Changsha, China

4 Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States

5 The Mongan Institute, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States

6 National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China

7 Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China

8 Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, China

Corresponding Author:

  • Yilun Wang, MD, PhD
  • Department of Orthopaedics
  • Xiangya Hospital, Central South University
  • 87 Xiangya Road
  • Changsha 410008
  • China
  • Phone: 86 84327326
  • Email: yilun_Wang@csu.edu.cn