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Quantitative Assessment of Strabismus Using Cloud AI Computing: Validation Study

Quantitative Assessment of Strabismus Using Cloud AI Computing: Validation Study

Most photoscreening devices, including smartphone apps, are limited to measuring manifested strabismus, and intermittent patients with strabismus are likely to be missed. The ability to elicit and capture the eye movement based on covering 1 or both eye alternatingly remains a challenging problem for mobile apps and many other photoscreening devices.

Junxian He, Jiawei Zhang, Zheng Wang, Shrinivas Pundlik, Rui Liu, Gang Luo

JMIR Form Res 2025;9:e79280


Perceived Digital Well-Being Scale in the United States and United Kingdom: Psychometric Validation Study

Perceived Digital Well-Being Scale in the United States and United Kingdom: Psychometric Validation Study

Smartphone use has become widespread in modern societies, particularly among young adults. This age group differs from older ones by having higher involvement in smartphone use and a greater propensity to use the devices for social interactions, dating, mental health, and well-being services [1-7]. Difficulties related to mastering smartphone use and specific digital services, such as social media, have been reported in numerous studies from multiple countries [8,9].

Germano Vera Cruz, Magdalena Liberacka-Dwojak, Monika Wiłkość-Dębczyńska, Merve Aktaş Terzioğlu, Todd Farchione, Tania Lecomte, Sandy Ingram, Riaz Khan, Yasser Khazaal

JMIR Ment Health 2025;12:e78334


Requirements and Concerns of Remitted Individuals With Depression for an Early Relapse Detection mHealth App: Focus Group Study

Requirements and Concerns of Remitted Individuals With Depression for an Early Relapse Detection mHealth App: Focus Group Study

Passive data is sourced from the user’s smartphone and smartwatch. Smartphone data contain phone usage patterns (eg, screen time per app), revealing a user’s digital footprint. Additionally, smartphones include a multitude of sensors (eg, accelerometers, GPS location sensors, and light and proximity sensors), providing detailed measurements about users’ daily life and their environment.

Tina Coenen, Matthias Maerevoet, Stephanie Chen, Mathias De Brouwer, Sofie Van Hoecke, Ernst HW Koster, Mariek MP Vanden Abeele, Klaas Bombeke

JMIR Mhealth Uhealth 2025;13:e67141


Augmented Reality Playgrounds to Promote Physical Activity in Young Children: Feasibility Study Using a Repeated Measures Laboratory Design

Augmented Reality Playgrounds to Promote Physical Activity in Young Children: Feasibility Study Using a Repeated Measures Laboratory Design

AR as a tool to encourage physical activity in children is attractive due to its easy access and portability, being predominantly used on a smart device (eg, smartphone or tablet) already owned by many families, and its ability for use in both indoor and outdoor environments.

Sarah M Stearne, Amber Beynon, Charlotte Lund Rasmussen, Juliana Zabatiero, Louise Paatsch, Daniel Johnson, Leon Straker, Amity Campbell

JMIR Pediatr Parent 2025;8:e75302


Quantifying Maternal Health Using Digital Phenotyping: Protocol for a Longitudinal Observational Study

Quantifying Maternal Health Using Digital Phenotyping: Protocol for a Longitudinal Observational Study

Previous perinatal digital phenotyping studies, such as the Mom2 B study [2] and the Postpartum Mothers Mobile Study [3], have shown the feasibility of smartphone-based prediction of outcomes, EMA for post partum and breastfeeding, and mobile tracking of maternal health. Although the Mom2 B study relied primarily on smartphone data, our protocol extends this work by integrating synchronized wearable data and multiple app-based platforms.

Amanda Glime, Taysir Mahmoud, Soni Rusagara, Alysa St Charles, Devika Lekshmi, Ashley Peterson, Aarti Sathyanarayana

JMIR Res Protoc 2025;14:e77175


Effectiveness, Engagement, and Safety of a Digital Therapeutic (CT-155/BI 3972080) for Treating Negative Symptoms in People With Schizophrenia: Protocol for the Phase 3 CONVOKE Randomized Controlled Trial

Effectiveness, Engagement, and Safety of a Digital Therapeutic (CT-155/BI 3972080) for Treating Negative Symptoms in People With Schizophrenia: Protocol for the Phase 3 CONVOKE Randomized Controlled Trial

Briefly, CT-155 was developed as a smartphone-based DTx that provides aspects of psychosocial intervention techniques adjunctive to standard-of-care antipsychotic medication to treat negative symptoms of schizophrenia [74,81]. CT-155 was granted Breakthrough Device designation in December 2023 [82]. Here, we discuss the rationale and study design for the CONVOKE study, which refers to study protocol version 5.0 (dated September 2024).

Shaheen E Lakhan, Cornelia Dorner-Ciossek, Olya Besedina, Faith Dickerson, Claudia Hastedt, Ridwana Isla, René S Kahn, Jean-Pierre Lindenmayer, Ruchi Mehta, Cassandra Snipes, Austin Speier, Wenbo Tang, Bailey Willis, Jamie Winderbaum Fernandez, Christoph von der Goltz, Abhishek Pratap

JMIR Res Protoc 2025;14:e81293


A Personalized and Smartphone-Based Serious Gaming App Targeting Cognitive Impairments in Alcohol Use Disorder: Double-Blinded, Randomized Controlled Efficacy Trial Among Outpatients

A Personalized and Smartphone-Based Serious Gaming App Targeting Cognitive Impairments in Alcohol Use Disorder: Double-Blinded, Randomized Controlled Efficacy Trial Among Outpatients

The aims of this feasibility and efficacy study were to assess the acceptability and feasibility of a semiguided, smartphone-based, serious gaming app administered as an add-on to conventional treatment among patients with AUD. As secondary objectives, we wanted to explore whether the training program could show improvements in cognitive performance and if potential benefits on alcohol consumption and craving could be observed.

Nicolaj Mistarz, Laust Vind Knudsen, Anna Mejldal, Kjeld Andersen, Anneke Goudriaan, Lotte Skøt, Tanja Maria Michel, Angelina Isabella Mellentin

JMIR Ment Health 2025;12:e67167


Bedtime App–Guided Mindfulness Meditation in Patients With Insomnia: Mixed Methods Feasibility and Acceptability Pilot Study

Bedtime App–Guided Mindfulness Meditation in Patients With Insomnia: Mixed Methods Feasibility and Acceptability Pilot Study

In practice, there has been a surge in the use of commercially available mindfulness-based smartphone apps as alternatives to formal interventions.

Yan Ma, Peter M Wayne, Janet M Mullington, Suzanne Bertisch, Gloria Y Yeh

JMIR Form Res 2025;9:e67366


App-Based Smoking Urge Reduction Intervention for Young Adults: Protocol Combining a Microrandomized Trial and Conventional Between-Subject Randomized Trial

App-Based Smoking Urge Reduction Intervention for Young Adults: Protocol Combining a Microrandomized Trial and Conventional Between-Subject Randomized Trial

Smartphones have wide reach and integration into young adults’ lives (98% own a smartphone) [9]. These devices offer great opportunities to deliver cessation interventions by delivering messages suggesting coping strategies “in the moment” when smokers need cessation support. However, few cessation apps deliver evidence-based intervention content [10,11] and content tailored to individual needs [12-14].

Johannes Thrul, Janardan Devkota, Joseph J C Waring, Michael R Desjardins, Josef Hamoud, Jasmin Han, Felix Naughton, Vadim Zipunnikov, Tamar Mendelson, Carl Latkin, David Epstein, Meghan Moran

JMIR Res Protoc 2025;14:e74388