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Fatigue is the most common symptom of systemic lupus erythematosus (SLE) and affects 80%‐90% of individuals with this chronic autoimmune inflammatory disease [1]. Fatigue significantly impacts morbidity and is a leading cause of withdrawal from the workforce, with unemployment rates ranging from 40% to 60% among individuals with SLE [1-8]. People living with SLE consistently cite fatigue as their greatest unmet need; however, the relationship between SLE disease activity and fatigue is complex [9-15].
JMIR Form Res 2025;9:e75399
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Fatigue has been presented as the most common symptom of MS, with a rate of up to 80% [8-10], whereas approximately 50% of patients with MS have been shown to have cognitive deficits [11]. The negative effects of cognitive problems and fatigue on working ability have been shown in registry-based studies [12,13]. Self-perceived cognitive problems and fatigue have shown a linear relationship with days on sick leave and a decrease in weekly working hours and self-perceived working ability [12].
JMIR Hum Factors 2025;12:e67990
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Fatigue is known to be an everyday problem for most individuals with visual impairment (VI) [1-4]. Consequences of fatigue on emotional and cognitive functioning, social roles, and participation in society have been reported to be problematic [5,6]. To address this difficulty, an intervention called E-nerg EYEze was developed tailored to the unique aspects of individuals with vision loss who experience severe fatigue and investigated in a randomized controlled trial (RCT) [7].
JMIR Form Res 2025;9:e53080
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This is the peer-review report for the preprint “Novel Fatigue Profiling Approach Highlights Temporal Dynamics of Human Sperm Motility.”
This review is the result of a virtual collaborative live review discussion organized and hosted by PREreview and JMIR Publications on June 26, 2025. The discussion was joined by 14 people: 2 facilitators from the PREreview team, 1 member of the JMIR Publications team, 1 author, and 10 live review participants.
JMIRx Bio 2025;3:e80919
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Compassion Fatigue and Burnout Among Health Care Professionals: Protocol for a Scoping Review
Psychological resilience and organizational support are fundamental for promoting well-being and reducing compassion fatigue [18,19].
The health care work relationship is strongly marked by the ambivalence between suffering and pleasure, with the physical and mental health of professionals often at risk [20].
JMIR Res Protoc 2025;14:e66360
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To measure the severity of fatigue, participants completed the Modified Fatigue Impact Scale-5 (MFIS-5) once every 4 weeks [30]. MFIS-5 assessed the impact of fatigue on cognitive, physical, and psychosocial function. Each item in MFIS-5 could score from 0 (never) to 4 (almost always) on a 5-point Likert scale, with higher scores indicating more severe fatigue.
To measure the severity of sleep disturbances, participants completed the Pittsburgh Sleep Quality Index (PSQI) once every 4 weeks [31].
J Med Internet Res 2025;27:e70871
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It is crucial to advise individuals to maintain their health and provide education on self-care, particularly regarding monitoring symptoms such as fatigue and shortness of breath post-COVID.
Vaccination guidance: Guidance should be provided regarding vaccination. It’s important to emphasize that vaccination against COVID-19 and influenza can strengthen immunity and prevent re-infection with COVID-19. This also reduces the risk of transmitting the virus again in the community.
JMIR Nursing 2025;8:e65310
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These digital measures hold the potential to provide objective assessments of fatigue that may complement self-reported fatigue to provide a more holistic view of fatigue. However, the identification and evaluation of objective digital measures of fatigue necessitates comparisons with perceived fatigue at relatively frequent intervals, preferably multiple times a day [10,11].
As such, this study focuses on evaluating the properties of a 4-times-a-day digital questionnaire.
JMIR Form Res 2025;9:e65879
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Chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis, is a complex chronic disease characterized by pathological fatigue, generalized weakness, immune dysfunction, poor sleep, pain, and cognitive impairments [1]. Its defining feature is persistent or recurrent debilitating fatigue that is not alleviated by rest and occurs despite the absence of significant abnormalities on physical examination or laboratory tests.
JMIR Res Protoc 2025;14:e65958
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Extended screen time and the use of electronic health records (EHRs) were associated with an increase in burnout and fatigue in bedside nurses [16]; however, the association between continuous screen time and virtual nurses’ fatigue levels, a key factor to the sustainability of this model, is unknown. Pupillometry data, which measures the change in pupil size, measures cognitive fatigue [17].
JMIR Hum Factors 2025;12:e67111
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