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Effectiveness and Implementation Outcomes of an mHealth App Aimed at Promoting Physical Activity and Improving Psychological Distress in the Workplace Setting: Cluster-Level Nonrandomized Controlled Trial

Effectiveness and Implementation Outcomes of an mHealth App Aimed at Promoting Physical Activity and Improving Psychological Distress in the Workplace Setting: Cluster-Level Nonrandomized Controlled Trial

In 2019, an estimated 301 million working-age adults experienced anxiety, while approximately 280 million had depression [1]. Furthermore, many workers report subclinical symptoms such as psychological distress [2-4]. These mental health concerns lead to increased absenteeism, deteriorating quality of life, and overall well-being [5]. The global economic burden of mental health conditions is estimated at approximately US $1 trillion annually, primarily due to productivity losses [1,6,7].

Kazuhiro Watanabe, Mitsuhiro Sato, Shoichi Okusa, Akizumi Tsutsumi

JMIR Mhealth Uhealth 2025;13:e70473

Impact of a Digital Decision Aid When Choosing Between Face-to-Face and Guided Internet-Based Psychological Interventions for Depression Among Chinese-Speaking Participants in Hong Kong: Randomized Controlled Trial

Impact of a Digital Decision Aid When Choosing Between Face-to-Face and Guided Internet-Based Psychological Interventions for Depression Among Chinese-Speaking Participants in Hong Kong: Randomized Controlled Trial

Depression is prevalent and a leading cause of disability, mortality, loss of productivity, and health care expenditure [1]. Psychological interventions not only are effective for the treatment of depression [2] but are also considered a first-line treatment for major depression [3]. Psychological interventions are also the preferred treatment method for most people with depression [4].

Larry Auyeung, Winnie WS Mak, Ella Zoe Tsang, Philo Liu Yang

J Med Internet Res 2025;27:e54727

Cognitive Behavioral Immersion for Depression: Protocol for a Three-Arm Randomized Controlled Trial of Peer-Based Coaching in the Metaverse

Cognitive Behavioral Immersion for Depression: Protocol for a Three-Arm Randomized Controlled Trial of Peer-Based Coaching in the Metaverse

Approximately 280 million people worldwide are experiencing depression [1], and nearly half of those people also experience comorbid anxiety [2]. Symptoms of either disorder can cause substantial distress and impair functioning across all domains of life. Worse yet, the prevalence and severity of these disorders are growing [3].

Noah Robinson, Francisco N Ramos, Steven D Hollon, Gloria T Han, Iony D Ezawa

JMIR Res Protoc 2025;14:e65970

Interventions to Foster Mental Health and Reintegration in Individuals Who Are Unemployed: Systematic Review

Interventions to Foster Mental Health and Reintegration in Individuals Who Are Unemployed: Systematic Review

Numerous studies have shown that the prevalence rates of clinically relevant mental health problems, such as symptoms of depression, anxiety disorders, and psychosomatic illnesses, are increased in the unemployed population compared with the employed population [6,7]. While the point prevalence of depression in the general population ranges between 6.38% [8] and 12.9% [9], an aggregate increased prevalence of 24% persists for individuals who are unemployed [7].

Sophia Helen Adam, Florian Junne, Svenja Schlachter, Miriam Mehler, Harald Gündel, Nicolas Rüsch, Jörn von Wietersheim, Katrin Elisabeth Giel, Stephan Zipfel, Rebecca Erschens

JMIR Public Health Surveill 2025;11:e65698

Virtual Versus In-Person Intensive Outpatient Treatment for Eating Disorders During the COVID-19 Pandemic in United States–Based Treatment Facilities: Naturalistic Study

Virtual Versus In-Person Intensive Outpatient Treatment for Eating Disorders During the COVID-19 Pandemic in United States–Based Treatment Facilities: Naturalistic Study

The COVID-19 pandemic exacerbated almost every mental health disorder, including anxiety, depression [1], and eating disorders (EDs) [2]. EDs are associated with high rates of morbidity and mortality [3], and poor quality of life [4]. Schlegl et al [2] found that while 70% of patients with EDs reported an increase in symptoms after the onset of COVID-19, access to in-person therapy decreased by 37% at the same time. Only 26% of patients surveyed used videoconferencing for therapy.

Dan V Blalock, Philip S Mehler, Deborah M Michel, Alan Duffy, Daniel Le Grange, Anne M O'Melia, Renee D Rienecke

J Med Internet Res 2025;27:e66465

The Longitudinal Effect of Psychological Distress on Internet Addiction Symptoms Among Chinese College Students: Cross-Lagged Panel Network Analysis

The Longitudinal Effect of Psychological Distress on Internet Addiction Symptoms Among Chinese College Students: Cross-Lagged Panel Network Analysis

The distress experiences were measured using the Depression Anxiety Stress Scale (DASS), which consists of 21 items divided into 3 subscales, with 7 items each, measuring depression, anxiety, and stress [38]. Items were rated on a 4-point Likert-type scale, ranging from 0 (did not apply) to 3 (applied most of the time). Total scores for each dimension were obtained by summing the item scores of the subscales, with possible totals ranging from 0 to 21 for each of the 3 factors.

Yuxuan Jiang, Chuman Xiao, Xiang Wang, Dongling Yuan, Qian Liu, Yan Han, Jie Fan, Xiongzhao Zhu

J Med Internet Res 2025;27:e70680

Testing the Effectiveness of a Gamified Emotional Cognitive Bias Modification Task as an Intervention for Low Mood: Randomized Controlled Trial

Testing the Effectiveness of a Gamified Emotional Cognitive Bias Modification Task as an Intervention for Low Mood: Randomized Controlled Trial

Depression is associated with a negative bias in the interpretation of facial emotional expressions [1,2]. This negative bias has been proposed to play an important role in the onset and maintenance of depression, as successful pharmacological interventions have been found to be associated with the reduction of negative biases [3]. It was previously thought that treating depression would lead to improvements in emotion recognition bias.

Rumeysa Kuruoğlu, Angela Attwood, Ian Penton-Voak

JMIR Serious Games 2025;13:e65103

Reduction of Anxiety-Related Symptoms Using Low-Intensity Ultrasound Neuromodulation on the Auricular Branch of the Vagus Nerve: Preliminary Study

Reduction of Anxiety-Related Symptoms Using Low-Intensity Ultrasound Neuromodulation on the Auricular Branch of the Vagus Nerve: Preliminary Study

Because depression [32] and PTSD [33] frequently co-occur with anxiety, we also investigated the efficacy of transauricular ultrasound VNS for alleviating the symptoms of depression and PTSD in individuals with anxiety. This was a pre-post-intervention study in which all participants received the intervention daily, at home, for a period of 4 weeks. The clinical trial is registered at Clinical Trials.gov [NCT06574971]. Informed consent was obtained from each of the 28 participants prior to screening.

Izzy Kohler, Jon Hacker, Ethan Martin

JMIR Neurotech 2025;4:e69770

Investigating Protective and Risk Factors and Predictive Insights for Aboriginal Perinatal Mental Health: Explainable Artificial Intelligence Approach

Investigating Protective and Risk Factors and Predictive Insights for Aboriginal Perinatal Mental Health: Explainable Artificial Intelligence Approach

Perinatal depression and anxiety (PNDA) negatively impact the health and well-being of mothers and babies, and disrupt maternal /infant bonding [1]. Recent studies highlighted the significant association between PNDA and adverse outcomes, including suicidal behaviors and self-harm thoughts during and after pregnancy. Roddy Mitchell et al [2] emphasized the increased risk of preterm birth, stillbirth, and suicide associated with PNDA.

Guanjin Wang, Hachem Bennamoun, Wai Hang Kwok, Jenny Paola Ortega Quimbayo, Bridgette Kelly, Trish Ratajczak, Rhonda Marriott, Roz Walker, Jayne Kotz

J Med Internet Res 2025;27:e68030