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Sodium Oxybate as a Potential New Treatment for Catatonia in Patients With Depression, Bipolar Disorder, or a Psychotic Disorder: Protocol for a Randomized Controlled Trial

Sodium Oxybate as a Potential New Treatment for Catatonia in Patients With Depression, Bipolar Disorder, or a Psychotic Disorder: Protocol for a Randomized Controlled Trial

Our study requires no adjustment of the type I error, given that it consists of 2 treatment groups and focuses on a single primary variable, response to treatment. The study follows a confirmatory statistical approach with a single, prespecified null hypothesis concerning the primary variable. For the secondary outcome measures, we will first determine the remission after 4 days and subsequently after 10 days of treatment using logistic regression.

Lilian Bot, Josine G van Mill, Laetitia J C A Smarius, Adriaan W Hoogendoorn, Bram W C Storosum, Christiaan H Vinkers, Gabriel E Jacobs, Gert Jan Lammers, Hanna M Heller, Jantine C A Colen-de Koning, Joris J B van der Vlugt, Marloes S Oudijn, Martijn S van Noorden, Pierre M Bet, Rolf Fronczek, Heleen S van der Heijden, Sjors M M Lange, Ysbrand D van der Werf, Eric R van Exel

JMIR Res Protoc 2025;14:e68356

Terminology and Definitions of Racial Health Equity in Prominent Health Websites: Systematic Review

Terminology and Definitions of Racial Health Equity in Prominent Health Websites: Systematic Review

A Definition and Discussion Guide” [54] (4/33, 12.1%), while for health disparity/disparities, 25% (6/24) cited “Healthy People 2020” [55] and 8.3% (2/24) cited “The Secretary’s Advisory Committee on National Health Promotion and Disease Prevention Objectives For 2020 Phase I Report” [56]. In total, 22.1% (2/9) health inequity/inequities definitions cited “The concepts and principles of equity and health” [57].

Mahederemariam Bayleyegn Dagne, Elizabeth A Terhune, Miriam Barsoum, Ana Beatriz Pizarro, Anita Rizvi, Damian K Francis, Meera Viswanathan, Nila A Sathe, Vivian Welch, Tiffany Duque, Robert W Turner II, Tamara A Baker, Patricia C Heyn

J Med Internet Res 2025;27:e64868

A Personalized, Texting-Based Conversational Agent to Address Sleep Disturbance in Individuals Who Have Survived Breast Cancer: Protocol for a Pilot Waitlist Randomized Controlled Trial

A Personalized, Texting-Based Conversational Agent to Address Sleep Disturbance in Individuals Who Have Survived Breast Cancer: Protocol for a Pilot Waitlist Randomized Controlled Trial

Diagnosis of stage I-III invasive breast cancer in the previous 5 years. Female gender. Clinically significant insomnia symptoms, defined as a T-score ≥55 on the Patient-Reported Outcomes Measurement Information System (PROMIS) Sleep Disturbance 8a. Self-report of insomnia symptoms lasting ≥3 months. Eastern Cooperative Oncology Group (ECOG) performance status of 0-2, indicating the ability to perform activities of daily living. Owns a smartphone with internet connectivity.

Chi-shan Tsai, Warren Szewczyk, Michelle Drerup, Jason Liao, Alexi Vasbinder, Heather Greenlee, Jaimee L Heffner, Rachel Yung, Kerryn W Reding

JMIR Res Protoc 2025;14:e62712

User-Driven Development of a Digital Behavioral Intervention for Chronic Pain: Multimethod Multiphase Study

User-Driven Development of a Digital Behavioral Intervention for Chronic Pain: Multimethod Multiphase Study

I put more stock in ACT. Acceptance, which is something I’ve worked really hard on because I’ve been a bit black or white.” [Patient 5] “I personally would have had a more difficult time if [I] met the patients face-to-face in this type of treatment without any support... Having a treatment program that you follow, I feel that the knowledge I have [then] about chronic pain is good enough.”

Afra Selma Taygar, Sara Laureen Bartels, Rocío de la Vega, Ida Flink, Linnéa Engman, Suzanne Petersson, Sophie I Johnsson, Katja Boersma, Lance M McCracken, Rikard K Wicksell

JMIR Form Res 2025;9:e74064

Using Large Language Models to Assess Burnout Among Health Care Workers in the Context of COVID-19 Vaccine Decisions and Health Beliefs: Retrospective Cohort Study

Using Large Language Models to Assess Burnout Among Health Care Workers in the Context of COVID-19 Vaccine Decisions and Health Beliefs: Retrospective Cohort Study

Similarly, the comment “I was working as an R.N. in the pandemic and eventually developed severe anxiety, panic attacks, and depression and am currently on a leave of absence from work for these reasons” strongly reflects Emotional Exhaustion, characterized by emotional and psychological depletion. However, the mention of a leave of absence might also suggest withdrawal, potentially overlapping with Depersonalization and contributing to misclassification.

Samaneh Omranian, Lu He, AkkeNeel Talsma, Arielle A J Scoglio, Susan McRoy, Janet W Rich-Edwards

JMIR Nursing 2025;8:e73672

Facial Emotion Recognition of 16 Distinct Emotions From Smartphone Videos: Comparative Study of Machine Learning and Human Performance

Facial Emotion Recognition of 16 Distinct Emotions From Smartphone Videos: Comparative Study of Machine Learning and Human Performance

Let A be a contingency matrix, where Aij is the number of instances of a class i classified as j. Let K be the number of classes. Then, the UAR [60] is defined as: For these initial experiments, the SVMs classified the 16 emotions, and we averaged the extracted FAUs from each video over the time domain to obtain a single, video-level feature representation as input for the SVMs. The UAR scores obtained from each participant varied between 4.4% and 39.8%, with a mean of 20.4% (SD 7.2%).

Marie Keinert, Simon Pistrosch, Adria Mallol-Ragolta, Björn W Schuller, Matthias Berking

J Med Internet Res 2025;27:e68942

Exploring the Acceptance and Opportunities of Using a Specific Generative AI Chatbot to Assist Parents in Managing Pediatric Rheumatological Chronic Health Conditions: Mixed Methods Study

Exploring the Acceptance and Opportunities of Using a Specific Generative AI Chatbot to Assist Parents in Managing Pediatric Rheumatological Chronic Health Conditions: Mixed Methods Study

I know the doctors do not have the time to spend with us to answer all our questions. One child or young person mentioned that they did not think of using Chat GPT for seeking health information before but for academic purposes only. Parents perceived the chatbot to be an efficient tool in terms of time and accessibility for information seeking, even when they were specifically asked about Chat GPT.

Cheryl W Y Lau, Klaudia Kupiec, Polly Livermore

JMIR Pediatr Parent 2025;8:e70409