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Feasibility and Acceptability of a mHealth Patient Navigation Intervention to Increase Pre-Exposure Prophylaxis Uptake in Racially and Ethnically Diverse Sexual and Gender Minority Youth in Los Angeles (PrEPresent): Pilot Randomized Controlled Trial

Feasibility and Acceptability of a mHealth Patient Navigation Intervention to Increase Pre-Exposure Prophylaxis Uptake in Racially and Ethnically Diverse Sexual and Gender Minority Youth in Los Angeles (PrEPresent): Pilot Randomized Controlled Trial

Despite a decrease in new HIV acquisitions within cisgender men (those who identify their gender with their sex assigned at birth) in the LGBTQ+ community, 67% of new HIV acquisitions are still attributed to sexual interactions within this group. Young sexual minority men, those between the ages of 13 and 34, make up just over half (56%) of new diagnoses [1].

Sam Calvetti, Bryan Lei, Jacob B Stocks, Matthew T Rosso, Manuel Puentes, Ramon Durazo-Arvizu, Lindsay Slay, Michele D Kipke, Lisa B Hightow-Weidman

JMIR Form Res 2025;9:e69255


Lessons Learned Identifying and Controlling Fraudulent Participation in Online Randomized Trials

Lessons Learned Identifying and Controlling Fraudulent Participation in Online Randomized Trials

The Boston ARCH Comorbidity Center, known as ARCHER (Addressing Related Comorbidities for HIV by Employing Remote Technologies), is a research center funded by the National Institute on Alcohol Abuse and Alcoholism.

Robert Siebers, Kara M Magane, Hattie Slayton, Skylar Karzhevsky, Tibor P Palfai, Ana M Abrantes, Lisa M Quintiliani, Michael D Stein

J Med Internet Res 2025;27:e77512


Formative Evaluation of an HIV Prevention App tailored for Latino Men Who Have Sex With Men: Acceptability and Usability Study

Formative Evaluation of an HIV Prevention App tailored for Latino Men Who Have Sex With Men: Acceptability and Usability Study

It features in-app health screenings that direct users to appropriate services: HIV testing and Pr EP service locator; mail delivery of condoms, lubricant, and home HIV and sexually transmitted infection tests; and customizable HIV testing and Pr EP care maintenance plans [19]. To date, no comprehensive HIV prevention app has been customized to address the Pr EP accessibility barriers faced by Latino MSM, representing an important research gap.

Valeria D Cantos, Humberto Posada-Orozco, Isabella Batina, Natalie Sanchez, Eric Rangel, Patrick S Sullivan, Andres Camacho-Gonzalez, Aaron J Siegler

JMIR Form Res 2025;9:e74208


Testing the Efficacy of 2 Interventions to Improve Health Outcomes and Quality of Life Among Rural Older Adults Living With HIV: Protocol for a Randomized Controlled Trial

Testing the Efficacy of 2 Interventions to Improve Health Outcomes and Quality of Life Among Rural Older Adults Living With HIV: Protocol for a Randomized Controlled Trial

In the United States, more than 59,000 people living with HIV reside in rural areas, and approximately 2000 rural residents are newly diagnosed with HIV each year [1]. Rural people living with HIV have higher mortality rates than nonrural people living with HIV [2,3] and are more likely to have mental illness, substance dependence, and social isolation [4-8].

Andrew E Petroll, Sabina Hirshfield, Katherine G Quinn, Steven A John, Olivia H Algiers, Liam Randall, David Wyley Long, Timothy McAuliffe, Jennifer L Walsh

JMIR Res Protoc 2025;14:e71429


Just-in-Time Adaptive Intervention to Improve HIV Prevention and Substance Use in Youth Experiencing Homelessness (MY-RIDE): Protocol for a Randomized Controlled Trial

Just-in-Time Adaptive Intervention to Improve HIV Prevention and Substance Use in Youth Experiencing Homelessness (MY-RIDE): Protocol for a Randomized Controlled Trial

Yet, homeless youth lack adequate access to HIV prevention, including highly effective pre- and postexposure prophylaxis medications (ie, pre-exposure prophylaxis medication [Pr EP] and postexposure prophylaxis medication [n PEP]) [8]. Despite the high proportion of homeless youth found to be eligible for Pr EP (84%) in 1 large study, only 29% knew what Pr EP was, and very few (14%) reported that they were actively trying to prevent HIV [9]. Substance use and stress increase the risk for HIV [10,11].

Diane Santa Maria, Nikhil Padhye, Michael Businelle, Natasha Slesnick, Stefani Ricondo, Marguerita Lightfoot

JMIR Res Protoc 2025;14:e78006


Acceptability, Needs, Concerns, and Barriers to Digital-Based Interventions for the Prevention of Mother-to-Child Transmission of HIV: Systematic Review and Qualitative Meta-Aggregation

Acceptability, Needs, Concerns, and Barriers to Digital-Based Interventions for the Prevention of Mother-to-Child Transmission of HIV: Systematic Review and Qualitative Meta-Aggregation

Since the onset of the epidemic, an estimated 88.4 million individuals are living with HIV, and approximately 42.3 million have died from HIV-related causes [1]. By the end of 2023, around 39.9 million individuals were living with HIV globally [1]. Although the global HIV prevalence among adults aged 15‐49 years is approximately 0.8%, the burden of the epidemic varies significantly across regions and countries [1].

Sidik Maulana, Kusman Ibrahim, Rachel H A Arbing, Iqbal Pramukti, Annisa Dewi Nugrahani, Luh Nik Armini, Muhammad Iqhrammullah, Wei-Ti Chen

JMIR Med Inform 2025;13:e64816


Perceptions of Daily and On-Demand HIV Pre-Exposure Prophylaxis and Digital Adherence-Support Needs Among Cisgender Men in Brazil: Qualitative Interview and Focus Group Study

Perceptions of Daily and On-Demand HIV Pre-Exposure Prophylaxis and Digital Adherence-Support Needs Among Cisgender Men in Brazil: Qualitative Interview and Focus Group Study

Oral HIV pre-exposure prophylaxis (Pr EP) consists of using 2 antiretroviral drugs (emtricitabine and tenofovir) to reduce the risk of HIV infection in unprotected sexual exposures. Currently, there are different ways of taking Pr EP, the most common being daily Pr EP, which consists of daily ingestion of the medication for an indefinite period.

Lorruan Alves dos Santos, Alexandre Grangeiro, Paula Massa, Marcia Thereza Couto

J Med Internet Res 2025;27:e66848


Integrating a Combination HIV Prevention Intervention Into a Widely Used Geosocial App for Chinese Men Who Have Sex With Men: Protocol for a Single-Arm Pilot and Repeated Cross-Sectional Study

Integrating a Combination HIV Prevention Intervention Into a Widely Used Geosocial App for Chinese Men Who Have Sex With Men: Protocol for a Single-Arm Pilot and Repeated Cross-Sectional Study

Gay and bisexual men who have sex with men have been disproportionately affected by HIV in China [1,2], where the population of men who have sex with men was estimated to be approximately 21 million in 2018 [3]. HIV prevalence among men who have sex with men was estimated to have increased from 1% to 6% between 2001 and 2018 [4]. The estimated HIV incidence among men who have sex with men is much higher than for all other populations identified as being at risk of HIV in China since 2010 [5].

Wenting Huang, Kunru Ning, Shi Hao Ernest Koh, Guodong Mi, Fei Yu, Yufen Liu, Daniel Stegmueller, Kimberly A Powers, Stefan Baral, Patrick S Sullivan, Aaron J Siegler

JMIR Res Protoc 2025;14:e69536


Identifying Factors Associated With HIV Viral Suppression and Health Care Outcomes in the Florida Cohort Study Wave 3: Protocol for a Prospective Cohort Study

Identifying Factors Associated With HIV Viral Suppression and Health Care Outcomes in the Florida Cohort Study Wave 3: Protocol for a Prospective Cohort Study

In 2019, there were 13.2 HIV diagnoses per 100,000 people in the United States. The Ending the HIV Epidemic (EHE) initiative was announced with the goal of reducing new HIV infections by 90% by 2030 [1]. A key pillar of the EHE is helping more people with HIV achieve and sustain viral suppression to decrease transmission of HIV [2].

Rebecca J Fisk-Hoffman, Christina E Parisi, Nanyangwe Siuluta, Preeti Manavalan, Lori A Bilello, Colby Cohen, Jessy Devieux, Gladys Ibanez, Jennifer Kuretski, Charurut Somboonwit, Maya Widmeyer, Zhi Zhou, Robert L Cook, Florida Cohort Wave 3 Team

JMIR Res Protoc 2025;14:e69702