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Sodium oxybate, the pharmacological agent used in this study, acts as a GABA-B receptor agonist and a precursor of GABA [24]. It was administered in doses ranging between 0.01 and 0.1 g/kg, 3 times daily either orally or intravenously (equivalent to 2.4-24 g/d for an 80 kg patient). Among patients with schizophrenia and catatonia, approximately 30 participants, the study showed a reduction of catatonic symptoms ranging from 60% to 70%.
JMIR Res Protoc 2025;14:e68356
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(B) Two scenarios of exclusion. Left: the onset (day 4) meets the definition, but the pain severity is at the personal median pain level, conflicting with the criterion for the end of a pain flare. Right: 2 flare onsets (days 2 and 4) meet the definition but end on the same day (day 5). The second onset (day 4) is removed to avoid double counting.
In addition to identifying pain flares by their severity, we examined their residual impact in the postflare phase.
JMIR Mhealth Uhealth 2025;13:e64889
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Conversational Systems for Social Care in Older Adults: Protocol for a Scoping Review
JMIR Res Protoc 2025;14:e72310
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