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Population-Based Digital Health Interventions to Deliver at-Home COVID-19 Testing: SCALE-UP II Randomized Clinical Trial

Population-Based Digital Health Interventions to Deliver at-Home COVID-19 Testing: SCALE-UP II Randomized Clinical Trial

Primary and secondary outcomes for the nonsmartphone study. aa RR: adjusted risk ratio. b Not available. c PN: patient navigation. The primary hypotheses for the smartphone study were main effects for delivery mechanism (ie, Chatbot more effective than SMS text messaging), main effects for PN (ie, PN more effective than no PN), and main effects for message frequency (ie, exposure to messages every 10 d more effective than every 30 d).

Guilherme Del Fiol, Tatyana V Kuzmenko, Brian Orleans, Jonathan J Chipman, Tom Greene, Ray Meads, Kimberly A Kaphingst, Bryan Gibson, Kensaku Kawamoto, Andy J King, Tracey Siaperas, Shlisa Hughes, Alan Pruhs, Courtney Pariera Dinkins, Cho Y Lam, Joni H Pierce, Ryzen Benson, Emerson P Borsato, Ryan C Cornia, Leticia Stevens, Richard L Bradshaw, Chelsey R Schlechter, David W Wetter

J Med Internet Res 2025;27:e74145

Sodium Oxybate as a Potential New Treatment for Catatonia in Patients With Depression, Bipolar Disorder, or a Psychotic Disorder: Protocol for a Randomized Controlled Trial

Sodium Oxybate as a Potential New Treatment for Catatonia in Patients With Depression, Bipolar Disorder, or a Psychotic Disorder: Protocol for a Randomized Controlled Trial

Sodium oxybate, the pharmacological agent used in this study, acts as a GABA-B receptor agonist and a precursor of GABA [24]. It was administered in doses ranging between 0.01 and 0.1 g/kg, 3 times daily either orally or intravenously (equivalent to 2.4-24 g/d for an 80 kg patient). Among patients with schizophrenia and catatonia, approximately 30 participants, the study showed a reduction of catatonic symptoms ranging from 60% to 70%.

Lilian Bot, Josine G van Mill, Laetitia J C A Smarius, Adriaan W Hoogendoorn, Bram W C Storosum, Christiaan H Vinkers, Gabriel E Jacobs, Gert Jan Lammers, Hanna M Heller, Jantine C A Colen-de Koning, Joris J B van der Vlugt, Marloes S Oudijn, Martijn S van Noorden, Pierre M Bet, Rolf Fronczek, Heleen S van der Heijden, Sjors M M Lange, Ysbrand D van der Werf, Eric R van Exel

JMIR Res Protoc 2025;14:e68356