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Effect of Physical Exercise on Telomere Length: Umbrella Review and Meta-Analysis

Effect of Physical Exercise on Telomere Length: Umbrella Review and Meta-Analysis

Indeed, one of the main theories that has attempted to explain aging relates to telomere length (TL) and the role of telomerase, an enzyme responsible for maintaining and elongating telomeres. Telomeres are essential nucleoprotein structures located at the termini of eukaryotic chromosomes that play pivotal roles in safeguarding genomic integrity and regulating processes such as tumor suppression and aging [4].

Juan Luis Sánchez-González, Juan Luis Sánchez-Rodríguez, Rogelio González-Sarmiento, Víctor Navarro-López, Raúl Juárez-Vela, Jesús Pérez, Javier Martín-Vallejo

JMIR Aging 2025;8:e64539