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Symptom Trajectories and Clinical Subtypes in Post–COVID-19 Condition: Systematic Review and Clustering Analysis

Symptom Trajectories and Clinical Subtypes in Post–COVID-19 Condition: Systematic Review and Clustering Analysis

Assuming a conservative estimate that 10% of recovered individuals will experience persistent symptoms, over 70 million people may be affected by the long-term sequelae of COVID-19. Post–COVID-19 condition presents with complex symptoms affecting multiple systems and organs throughout the body, with studies reporting over 200 types of symptoms [7]. Common symptoms include fatigue, postexertional malaise, cognitive impairment (brain fog), dyspnea, chest pain, as well as anxiety and depression [8,9].

Mingzhi Hu, Tian Song, Zhaoyuan Gong, Qianzi Che, Jing Guo, Lin Chen, Haili Zhang, Huizhen Li, Ning Liang, Guozhen Zhao, Yanping Wang, Nannan Shi, Bin Liu

JMIR Public Health Surveill 2025;11:e72221

Temporal Association Between ChatGPT-Generated Diarrhea Synonyms in Internet Search Queries and Emergency Department Visits for Diarrhea-Related Symptoms in South Korea: Exploratory Study

Temporal Association Between ChatGPT-Generated Diarrhea Synonyms in Internet Search Queries and Emergency Department Visits for Diarrhea-Related Symptoms in South Korea: Exploratory Study

Gastrointestinal symptoms, such as abdominal pain, diarrhea, and vomiting, are indicators for identifying symptom outbreaks and monitoring public health trends [15]. However, many symptoms related to diarrhea have been overlooked, and identifying appropriate keywords for gastrointestinal symptoms remains challenging [9,16]. Many studies have explored large language models and their applications in gastrointestinal diseases.

Jinsoo Kim, Ansun Jeong, Juseong Jin, Sangjun Lee, Do Kyoon Yoon, Soyeoun Kim

J Med Internet Res 2025;27:e65101

Therapeutic Guidelines for the Self-Management of Major Depressive Disorder: Scoping Review

Therapeutic Guidelines for the Self-Management of Major Depressive Disorder: Scoping Review

Therapies for the treatment of major depressive disorder, such as psychobiosocial therapies, psychotherapy, and pharmacotherapy, have advanced and are used according to the severity of the symptoms and potential adverse events [4].

Priscila de Campos Tibúrcio, Priscila Maria Marcheti, Daniela Miori Pascon, Marco Antônio Montebello Junior, Maria Alzete de Lima, Carla Sílvia Fernandes, Célia Samarina Vilaça de Brito Santos, Maria do Perpétuo Socorro de Sousa Nóbrega

Interact J Med Res 2025;14:e63959

Investigating Smartphone-Based Sensing Features for Depression Severity Prediction: Observation Study

Investigating Smartphone-Based Sensing Features for Depression Severity Prediction: Observation Study

Furthermore, if they are implemented, they typically take place at a fixed time point and assess symptoms retrospectively, which makes them subject to several biases (eg, recall bias) and unable to assess the dynamic and fluctuating nature of mental health [16-18].

Yannik Terhorst, Eva-Maria Messner, Kennedy Opoku Asare, Christian Montag, Christopher Kannen, Harald Baumeister

J Med Internet Res 2025;27:e55308

Assessment, Decision, Adaptation, Production, Topical Experts-Integration, Training, and Testing (ADAPT-ITT) Framework to Tailor Evidence-Based Posttraumatic Stress Disorder Treatment for People With HIV to Enhance Engagement and Adherence: Qualitative Results from a Feasibility Randomized Controlled Trial

Assessment, Decision, Adaptation, Production, Topical Experts-Integration, Training, and Testing (ADAPT-ITT) Framework to Tailor Evidence-Based Posttraumatic Stress Disorder Treatment for People With HIV to Enhance Engagement and Adherence: Qualitative Results from a Feasibility Randomized Controlled Trial

In turn, stigmatization can manifest in significant health disparities including poorer health outcomes, elevated PTSD symptoms due to reinforcement of avoidant coping behaviors, and delayed enrollment in HIV care until significantly ill [18-22]. Theoretical models jointly attribute the observed health disparities to the presence of “minority stress” and the absence of “social safety” among PWH, especially those who experience intersectional stigma.

Cristina M Lopez, Angela D Moreland, Stephanie Amaya, Erin Bisca, Christin Mujica, Tayler Wilson, Nathaniel Baker, Lauren Richey, Allison Ross Eckard, Patricia A Resick, Steven A Safren, Carla Kmett Danielson

JMIR Form Res 2025;9:e64258

Design and Use of Patient-Facing Electronic Patient-Reported Outcomes and Sensor Data Visualizations During Outpatient Chemotherapy

Design and Use of Patient-Facing Electronic Patient-Reported Outcomes and Sensor Data Visualizations During Outpatient Chemotherapy

Chemotherapy can cause significant symptoms that impact the quality of life [1]. Although electronic patient-reported outcome (e PRO) systems for collecting symptom ratings from patients have become increasingly common in cancer care, most of these are designed for clinicians, and fewer than half share data visualizations with the patients [2,3].

Christianna Bartel, Leeann Chen, Weiyu Huang, Qichang Li, Qingyang Li, Jennifer Fedor, Krina C Durica, Carissa A Low

JMIR Cancer 2025;11:e62711

Efficacy of the mHealth App Intellect in Improving Subclinical Obsessive-Compulsive Disorder in University Students: Randomized Controlled Trial With a 4-Week Follow-Up

Efficacy of the mHealth App Intellect in Improving Subclinical Obsessive-Compulsive Disorder in University Students: Randomized Controlled Trial With a 4-Week Follow-Up

OCD symptoms exist on a spectrum that varies in frequency and intensity across clinical and nonclinical populations [6]. Compared with the general population, individuals with subclinical OCD symptoms reported significantly lower life satisfaction and quality of life, and greater health care use [7].

Madeline Lee Yoon Li, Stephanie Lee Si Min, Oliver Sündermann

JMIR Mhealth Uhealth 2024;12:e63316

Exploring Self-Reported Symptoms for Developing and Evaluating Digital Symptom Checkers for Polycystic Ovarian Syndrome, Endometriosis, and Uterine Fibroids: Exploratory Survey Study

Exploring Self-Reported Symptoms for Developing and Evaluating Digital Symptom Checkers for Polycystic Ovarian Syndrome, Endometriosis, and Uterine Fibroids: Exploratory Survey Study

Despite the symptoms of these conditions being well-established in medical guidelines, diagnostic delays are common, with patients enduring between 2 and 12 years from the onset of their symptoms before they receive a formal diagnosis [8-10]. These delays could be due to complexities in diagnostic procedure [11], controversy in diagnostic evaluation [12], or affected persons having low knowledge of reproductive conditions and their symptoms [13].

Aidan P Wickham, Yella Hewings-Martin, Frederick GB Goddard, Allison K Rodgers, Adam C Cunningham, Carley Prentice, Octavia Wilks, Yusuf C Kaplan, Andrei Marhol, András Meczner, Heorhi Stsefanovich, Anna Klepchukova, Liudmila Zhaunova

JMIR Form Res 2024;8:e65469

Personalized Smartphone-Enabled Assessment of Blood Pressure and Its Treatment During the SARS-CoV-2 COVID-19 Pandemic in Patients From the CURE-19 Study: Longitudinal Observational Study

Personalized Smartphone-Enabled Assessment of Blood Pressure and Its Treatment During the SARS-CoV-2 COVID-19 Pandemic in Patients From the CURE-19 Study: Longitudinal Observational Study

The app was developed as a data collection interface and modified to additionally collect COVID-19 symptoms as well as current antihypertensive medications, based on a curated set of hypertension drugs and doses that were identified as potentially impacting COVID-19 symptoms. These modifications, along with the existing prototype app experience and an incentives scheme rewarding patient adherence, were used to promote patient engagement in the data collection process.

Leanne Richardson, Nihal Noori, Jack Fantham, Gregor Timlin, James Siddle, Thomas Godec, Mike Taylor, Charles Baum

JMIR Mhealth Uhealth 2024;12:e53430