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Stroke is one of the most debilitating brain disorders, often leading to death or severe functional impairment. The global burden of stroke is exceptionally high in low- and middle-income countries, where increased incidence, mortality, disability, and economic strain are prevalent [1]. Stroke is the second leading cause of death and disability worldwide [2], with over 116 million healthy years lost annually due to disabilities and fatalities associated with stroke [3].
JMIR Res Protoc 2025;14:e68340
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Despite intensive functional rehabilitation efforts, 75% of people who sustained a stroke continue to experience difficulties with hand sensorimotor impairments beyond 3 months after stroke, which negatively affect their participation in daily activities [1].
JMIR Neurotech 2025;4:e69750
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Validation and Refinement of Scores to Predict Stroke Risk: Prospective Cohort Study
The Global Burden of Disease (GBD) 2021 study found that the number of new cases of stroke increased by 70.2% from 1990 to 2021 [1], highlighting a relatively insufficient emphasis on prevention, particularly in low-income countries. The number of patients with stroke in China is currently the highest in the world. Stroke is the leading cause of death and disability among adults in the country [2]. China has the highest risk of stroke globally, with an overall lifetime risk of 39.9% [3].
JMIR Public Health Surveill 2025;11:e72497
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Aphasia, an acquired language disorder most commonly caused by stroke, impacts linguistic expression and comprehension in both written and oral modalities. People with aphasia may have impairments in their ability to speak, understand, read, and write. Thus, aphasia can severely limit activities and restrict participation in everyday activities [1].
JMIR Mhealth Uhealth 2025;13:e67711
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Falls are a common and serious problem after stroke. In the first year following a stroke, approximately 70% of individuals fall [1-3], and the risk of falls remains substantially elevated throughout the stroke survivor’s lifespan [2]. The physical consequences of falls can be devastating, often leading to hospitalizations, serious injuries, and even death [4].
JMIR Form Res 2025;9:e67297
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Stroke represents a leading cause of global morbidity and long-term disability [1], imposing a substantial burden on health care systems through its high incidence and the complex, prolonged care needs of survivors of stroke [2].
JMIR Med Inform 2025;13:e76636
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Elevated systolic and diastolic blood pressure (BP) are associated with an increased risk for stroke [1]. An American Heart Association (AHA) Presidential Advisory Committee projected that hypertension prevalence will increase from 51.2% in 2020 to 61.0% in 2050, leading to higher rates of cardiovascular disease and stroke. The committee also projected an increase in total cardiovascular disease by 3.7% [2].
JMIR Form Res 2025;9:e62700
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The questionnaire was developed to assess clinicians’ awareness and confidence regarding AF-related stroke prevention. It included a series of statements related to their knowledge of AF guidelines, their confidence in assessing stroke and bleeding risks using the CHA2 DS2-VASc and ORBIT scales, and their confidence in managing patients at risk of stroke. Each statement was rated on a Likert scale, ranging from strongly disagree to strongly agree (Multimedia Appendix 1).
JMIR Cardio 2025;9:e66428
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Stroke is currently the leading cause of disability and death in China, with a high incidence, high disability rate, high mortality rate, and high recurrence rate [1]. In China, approximately 3 million new patients with stroke are diagnosed annually, and 70%-80% of stroke survivors experience residual limb paralysis, which prevents them from living independently. Poststroke spasticity (PSS) is the most prevalent of these disabilities [2].
JMIR Res Protoc 2025;14:e65829
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Notably, stroke is the third leading cause of long-term disability in most countries and can result in paralysis, speech impairment, loss of memory and reasoning ability, coma, or even death [9]. Additionally, acquired brain injuries, such as traumatic brain injury, can lead to similar long-term disabilities, including balance and motor impairments, cognitive complaints related to memory and concentration, and chronic headache [10].
JMIR Res Protoc 2025;14:e68358
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