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Efficacy of Fuzheng Quxie Formula Against Postoperative Metastasis of Lung Cancer in Stage IIA-IIIA With Negative Driver Genes: Protocol for a Multicenter, Double-Blind, Randomized Controlled Trial

Efficacy of Fuzheng Quxie Formula Against Postoperative Metastasis of Lung Cancer in Stage IIA-IIIA With Negative Driver Genes: Protocol for a Multicenter, Double-Blind, Randomized Controlled Trial

Lung cancer is one of the most common malignant tumors of the respiratory system, with the mortality rate perennially ranking first among all kinds of malignant tumors, which greatly threatens the safety of human life [1]. In developed countries (such as the United States), lung cancer is still the malignant tumor with the highest number of deaths [2].

Fan Xu, Yun Yang, Yinbin Luo, Bin Luo, Jialiang Yao, Yiyang Zhou, Minghua Li, Jianchun Wu, Wenfei Shi, Lei Jiang, Qian Huang, Wentao Fang, Zhihong Fang, Yan Li, Jianhui Tian

JMIR Res Protoc 2025;14:e66342


Efficacy and Safety of Acupuncture at Sensitized Acupoints for Knee Osteoarthritis: Protocol for a Multicenter, Single-Blind Randomized Controlled Trial

Efficacy and Safety of Acupuncture at Sensitized Acupoints for Knee Osteoarthritis: Protocol for a Multicenter, Single-Blind Randomized Controlled Trial

In addition, we will focus on the sustained effects after treatment cessation through a 24-week extended follow-up and document safety profiles to comprehensively determine the clinical utility of this sensitization-guided acupuncture approach. Furthermore, previous RCTs exhibited heterogeneity and inadequate justification in acupoint selection.

Zenan Wu, Zehao Hu, Zixuan Xu, Tao Xiao, Qiuxuan Huang, Xu Zhou, Haifeng Zhang, Yong Fu

JMIR Res Protoc 2025;14:e77336


Social Media Use, Influencer Status, and Outdoor Risk-Taking in Australian Adults: Cross-Sectional Survey

Social Media Use, Influencer Status, and Outdoor Risk-Taking in Australian Adults: Cross-Sectional Survey

These mechanisms reinforce high-engagement content, which often includes dramatic or risky imagery, indirectly incentivizing risk-taking behaviors [5,6], which we define in this study as self-reported engagement in actions in outdoor settings that could endanger personal safety, undertaken specifically for the purpose of creating content for social media platforms. Theoretical frameworks help explain why individuals may engage in these behaviors.

Samuel Cornell, Amy Peden

JMIR Public Health Surveill 2025;11:e73089


The Safety of Telerehabilitation: Systematic Review

The Safety of Telerehabilitation: Systematic Review

Assessing the safety of telerehabilitation is important for guiding decisions made by patients, providers, and funders. For patients, a clearer understanding of its safety can offer reassurance and encourage broader adoption of telerehabilitation [12]. Providers rely on safety data to tailor treatments to individual conditions and refine protocols to minimize adverse events [13]. Funders rely on this information to justify coverage decisions and guide the allocation of resources and financial support [14].

Hila Shnitzer, Josh Chan, Thomas Yau, McKyla McIntyre, Angie Andreoli, Ailene Kua, Mark Bayley, Carl Froilan Leochico, Meiqi Guo, Sarah Munce

JMIR Rehabil Assist Technol 2025;12:e68681


Understanding Barriers to Home Safety Assessment Adoption in Older Adults: Qualitative Human-Centered Design Study

Understanding Barriers to Home Safety Assessment Adoption in Older Adults: Qualitative Human-Centered Design Study

This study aimed to (1) identify specific barriers perceived by community-dwelling older adults in accessing and implementing home safety assessments and modifications, (2) explore attitudes of health care professionals and additional stakeholders toward home safety assessments, and (3) identify novel design opportunities to guide the development and implementation of more effective home safety assessment techniques and practices.

Jonathan J Lee, Devika Patel, Meghana Gadgil, Simone Langness, Christiana Dagmar von Hippel, Amanda Sammann

JMIR Hum Factors 2025;12:e66854


Feasibility of a 12-Week, Therapist-Independent, Smartphone-Based Biofeedback Treatment for Episodic Migraine in Adults: Single-Center, Open-Label, 1-Armed Trial

Feasibility of a 12-Week, Therapist-Independent, Smartphone-Based Biofeedback Treatment for Episodic Migraine in Adults: Single-Center, Open-Label, 1-Armed Trial

The purpose of this study is to assess the feasibility, usability, and safety of 12 weeks of daily use of a home-based biofeedback system as a preventative in adults with episodic migraine. The findings of the study are intended to lead to refinements in the feasibility and usability of Cerebri (version 0.1.0; Nordic Brain Tech AS) and guide study design choices for a future randomized controlled trial. The study was a single-center, open-label, one-armed interventional trial conducted at St.

Amalie Christine Poole, Ingunn Grøntveit Winnberg, Melanie Rae Simpson, Anker Stubberud, Kjersti Grøtta Vetvik, Marte-Helene Bjørk, Lise Rystad Øie, Petter Holmboe, Alexander Olsen, Erling Tronvik, Tore Wergeland

JMIR Hum Factors 2025;12:e59622


Pharmaceutical Analysis of Inpatient Prescriptions: Systematic Observation of Hospital Pharmacists’ Practices in the Early User-Centered Design Phase

Pharmaceutical Analysis of Inpatient Prescriptions: Systematic Observation of Hospital Pharmacists’ Practices in the Early User-Centered Design Phase

The pharmacy department is responsible for the entire hospital’s health care product circuit, and the pharmacist’s activity is essential to patient safety and the reduction of health care expenditure [13]. Several studies have demonstrated the value of pharmacist-oriented CDSSs for patient management [10-12]. Of course, in health care, the patient’s well-being is the main concern.

Jesse Butruille, Natalina Cirnat, Mariem Alaoui, Jérôme Saracco, Etienne Cousein, Noémie Chaniaud

JMIR Hum Factors 2025;12:e65959


Impact of Tai Chi Therapy on Fatigue and Cognitive Function in Individuals With Chronic Fatigue Syndrome: Protocol for a Pilot Randomized Controlled Trial

Impact of Tai Chi Therapy on Fatigue and Cognitive Function in Individuals With Chronic Fatigue Syndrome: Protocol for a Pilot Randomized Controlled Trial

However, the impact of Tai Chi on cognitive functions in CFS has not yet been clinically validated, and its efficacy and safety have not been assessed in large-scale randomized controlled trials. Regular Tai Chi practice is beneficial for relieving fatigue and improving cognition in CFS, and it is more effective than general aerobic exercise.

Bin Wang, Xiaodong Zhang, Ping Lu, Pingping Sun, Tianxiang He

JMIR Res Protoc 2025;14:e65958


Improving Safety, Efficiency, Cost, and Satisfaction Across a Musculoskeletal Pathway Using the Digital Assessment Routing Tool for Triage: Quality Improvement Study

Improving Safety, Efficiency, Cost, and Satisfaction Across a Musculoskeletal Pathway Using the Digital Assessment Routing Tool for Triage: Quality Improvement Study

“Getting It Right First Time” by stratifying patients to the correct level of intervention at the first point of contact is considered key in ensuring patient safety and improving outcomes of MSK conditions and efficiency across the MSK pathway, with early identification of patients requiring urgent medical review considered a priority [5,6]. For this reason, patient safety was the primary measure for our study.

Cabella Lowe, Laura Atherton, Peter Lloyd, Anna Waters, Dylan Morrissey

J Med Internet Res 2025;27:e67269