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Evaluating the Safety and Efficacy of a Non–Weight-Centric Approach to Obesity Prevention in Rural and Urban Female Adolescents: Quasi-Experimental Study

Evaluating the Safety and Efficacy of a Non–Weight-Centric Approach to Obesity Prevention in Rural and Urban Female Adolescents: Quasi-Experimental Study

It delivers culturally sensitive, age-appropriate content in Arabic, ensuring accessibility for students in underresourced rural areas. Importantly, the program emphasizes macronutrient education, metabolic disease prevention, and strength-building exercises that do not require special facilities, making it feasible for rural schools with limited infrastructure.

Areeg Zuair, Rola Jalloun, Naif Alzahrani, Fahad Alhowaymel, Esraa Merza, Bandar Alhumaidi, Mohammad Alahmadi

Interact J Med Res 2025;14:e71341


Testing the Efficacy of 2 Interventions to Improve Health Outcomes and Quality of Life Among Rural Older Adults Living With HIV: Protocol for a Randomized Controlled Trial

Testing the Efficacy of 2 Interventions to Improve Health Outcomes and Quality of Life Among Rural Older Adults Living With HIV: Protocol for a Randomized Controlled Trial

In the United States, more than 59,000 people living with HIV reside in rural areas, and approximately 2000 rural residents are newly diagnosed with HIV each year [1]. Rural people living with HIV have higher mortality rates than nonrural people living with HIV [2,3] and are more likely to have mental illness, substance dependence, and social isolation [4-8].

Andrew E Petroll, Sabina Hirshfield, Katherine G Quinn, Steven A John, Olivia H Algiers, Liam Randall, David Wyley Long, Timothy McAuliffe, Jennifer L Walsh

JMIR Res Protoc 2025;14:e71429


Multiuser Application for the Diagnosis and Treatment of Depression in Women’s Self-Help Groups: Pilot Randomized Controlled Trial

Multiuser Application for the Diagnosis and Treatment of Depression in Women’s Self-Help Groups: Pilot Randomized Controlled Trial

In general, access to mobile phones is lower among women in India, especially in rural India, as women have time allocation constraints on phone usage, limited digital skills, and often depend on men for phone ownership [10,11]. Given these contextual considerations, we used a participatory design to develop and test an app—Multiuser Interactive Health Response Application (MITHRA)—that screens for depression and provides a brief behavioral intervention [12].

Amritha Bhat, Ruben Johnson-Pradeep, Bharat Kalidindi, Dhinagaran Devadass, B Ramakrishna Goud, Tony Raj, Sumithra Selvam, Yesenia Navarro-Aguirre, Pamela Y Collins, Krishnamachari Srinivasan

JMIR Form Res 2025;9:e68052


Introducing Public Health Vending Machines in Rural Communities: Protocol for a Study Using a Community-Based Participatory Approach

Introducing Public Health Vending Machines in Rural Communities: Protocol for a Study Using a Community-Based Participatory Approach

The number of deaths from drug overdoses has increased drastically, particularly among individuals living in rural areas throughout the country [3]. In studies examining where overdose deaths occurred, it was found that rural areas had the highest rates of drug overdose deaths [1]. Recently, the United States has experienced a notable decline in drug overdose deaths, marking a significant shift in the trajectory of the overdose crisis.

Meghan Guter, Lauren Harrell, Kathleen L Egan, Reese Hiatt, Lori Ann Eldridge

JMIR Res Protoc 2025;14:e64913


Representation of Rural Older Adults in AI for Health Research: Systematic Literature Review

Representation of Rural Older Adults in AI for Health Research: Systematic Literature Review

The demographic shift toward an aging population is particularly pronounced in rural areas, where access to health care is often limited. Over the past decade, 106 rural hospitals in the United States have closed [6,7], and another 600 are at risk of following suit [8], leaving rural communities increasingly vulnerable to limited access to essential health care services.

Kristina Shiroma, Jacqueline Miller

JMIR Hum Factors 2025;12:e70057


Video and Telephone Telehealth Use and Web-Based Patient Portal Activation Among Rural-Dwelling Patients: Retrospective Medical Record Review and Policy Implications

Video and Telephone Telehealth Use and Web-Based Patient Portal Activation Among Rural-Dwelling Patients: Retrospective Medical Record Review and Policy Implications

In the United States, rural populations experience worse outcomes related to the most common health conditions as well as a higher burden of morbidity and mortality compared to urban populations [1-5]. These rural health disparities are often more pronounced among rural populations of color, who make up about 20% of rural US residents [3,6,7]. Rural health disparities negatively impact rural social systems and prevent rural communities from thriving [8].

Meghan Rowe Ferrara, Gina Intinarelli-Shuler, Susan A Chapman

J Med Internet Res 2025;27:e67226


Usability Testing of an Internet-Based Responsive Parenting Program for Caregivers of Young Survivors of Childhood Cancer Living in Rural and Appalachian Communities: Mixed Methods Study

Usability Testing of an Internet-Based Responsive Parenting Program for Caregivers of Young Survivors of Childhood Cancer Living in Rural and Appalachian Communities: Mixed Methods Study

Digital health interventions may be a potential solution to increase access to specialized care for underserved populations [20], such as rural and Appalachian young survivors of childhood cancer and their caregivers. Recent systematic reviews have identified over 30 studies (N=32) focused on digital health interventions for families of children with special health care needs [21].

Emily L Moscato, Eva Darow, Jessica Quach, Adrien M Winning, Matthew Schmidt, Shari L Wade, Cynthia A Gerhardt, Emre Sezgin

JMIR Pediatr Parent 2025;8:e70055


Promoting Intergenerational Health in Rural Kentuckians With Diabetes (PIHRK’D): Protocol for a Longitudinal Cohort Study

Promoting Intergenerational Health in Rural Kentuckians With Diabetes (PIHRK’D): Protocol for a Longitudinal Cohort Study

Type 2 diabetes mellitus (T2 DM) and obesity have a compounding effect on health disparities in rural communities in Kentucky. T2 DM is a persistent public health condition affecting 34.1 million US adults [1]. Moreover, geographic disparities exist with some population segments, such as rural-dwelling Americans who experience greater vulnerability to this condition. The prevalence of T2 DM in Kentucky’s rural counties has reached 23%, compared to the overall state prevalence of 13.8% [2].

Brittany L Smalls, Courtney L Ortz, Makenzie Barr-Porter, Heather Norman-Burgdolf, Christopher J McLouth, Brittany Harlow, Oluwatosin Leshi

JMIR Res Protoc 2025;14:e69301


Evaluating the Effectiveness of a Mobile HIV Prevention App to Increase HIV and Sexually Transmitted Infection Testing and Pre-Exposure Prophylaxis Initiation Among Rural Men Who Have Sex With Men in the Southern United States: Protocol for a Randomized Controlled Trial

Evaluating the Effectiveness of a Mobile HIV Prevention App to Increase HIV and Sexually Transmitted Infection Testing and Pre-Exposure Prophylaxis Initiation Among Rural Men Who Have Sex With Men in the Southern United States: Protocol for a Randomized Controlled Trial

Overall, in the United States, 80% of rural residents are non-Hispanic White [7], whereas the overall US population is 60% non-Hispanic White [1]. However, southern states have much larger populations of rural residents of color [8]. Of the 17 states that comprise the Southern United States, 13 have >20% rural populations of color; 3 states (South Carolina, Mississippi, and Texas) have rural populations comprising >40% people of color [8].

Jeb Jones, Georgia Manley, Tiffany R Glynn, Kristin M Wall, Stefan D Baral, E Danny Harris, David Benkeser, Patrick S Sullivan

JMIR Res Protoc 2025;14:e69540


Falls Prevention Among Older Adults in Rural Communities: Protocol for a Scoping Review

Falls Prevention Among Older Adults in Rural Communities: Protocol for a Scoping Review

Although 2 literature reviews exist on falls, they focus primarily on rural older adults in the Australian context. For example, Boehm and colleagues [13] completed a literature review focusing on falls epidemiology in rural Australia. Similarly, Peters and colleagues [14] focused on the rural Australian context and examined paramedicine practices in supporting rural falls management. However, no existing literature reviews focus on the viewpoints of rural older adults.

Megan Funk, Juanita-Dawne Bacsu, Melba Sheila D’Souza, Anila Virani, Zahra Rahemi, Matthew Lee Smith

JMIR Res Protoc 2025;14:e63716