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Exploring the Perspectives of Pediatric Health Care Providers, Youth Patients, and Caregivers on Machine Learning Suicide Risk Classification: Mixed Methods Study

Exploring the Perspectives of Pediatric Health Care Providers, Youth Patients, and Caregivers on Machine Learning Suicide Risk Classification: Mixed Methods Study

There is, therefore, an opportunity to identify those who may be at elevated risk of suicide and intervene to prevent suicide deaths [4-6]. Toward this end, health care facilities use various risk identification tools, such as clinical judgment, brief screening, and risk assessment processes [7].

Rohan R Dayal, Pua Lani Yang, Laura Nicole Sisson, Mira Bajaj, Shannon Archuleta, Sophie Yao, Daniel H Park, Hanae Fujii-Rios, Emily E Haroz

J Med Internet Res 2025;27:e57602

Novel Virtual Reality Intervention for Stress Reduction Among Patients With or at Risk for Cardiovascular Disease: Mixed Methods Pilot Study

Novel Virtual Reality Intervention for Stress Reduction Among Patients With or at Risk for Cardiovascular Disease: Mixed Methods Pilot Study

Research has clearly demonstrated that positive psychological states are associated with a lower risk of cardiovascular disease (CVD) and mortality, while negative psychological factors such as chronic stress, anxiety, and depression can negatively impact cardiovascular health [1-10]. Further, chronic stress is associated with a 40%‐50% increase in the risk of coronary artery disease [4].

Katherine E Makaroff, Christopher Van, Vincent Grospe, Lynae Edmunds, Marcella A Calfon-Press, Karol E Watson, Tamara Horwich

JMIR Cardio 2025;9:e66557

Authors’ Response to Peer Reviews of “Cardiotoxicity in Pediatric Cancer Survivorship: Retrospective Cohort Study”

Authors’ Response to Peer Reviews of “Cardiotoxicity in Pediatric Cancer Survivorship: Retrospective Cohort Study”

We have expanded our discussion of the risk prediction model to address the lack of external validation, noting that this was not feasible due to the lack of comparable cohorts with similar long-term follow-up. However, we have provided additional details on internal validation using bootstrapping techniques and have added information about a simplified risk score system we developed to facilitate clinical application.

Masab Mansoor, Andrew Ibrahim

JMIRx Med 2025;6:e79672

Peer Review of “Cardiotoxicity in Pediatric Cancer Survivorship: Retrospective Cohort Study”

Peer Review of “Cardiotoxicity in Pediatric Cancer Survivorship: Retrospective Cohort Study”

The manuscript presents a risk prediction model (C statistic 0.78), but there is no external validation or discussion of its clinical applicability. Validate the model using an independent dataset (eg, a subset of Childhood Cancer Survivor Study data withheld from model training or another survivor cohort). Report calibration metrics (eg, Hosmer-Lemeshow test, calibration plots) to assess model accuracy. Provide a clinical risk score or decision framework for practical implementation.

John Lucas Jr

JMIRx Med 2025;6:e79523

Cardiotoxicity in Pediatric Cancer Survivorship: Retrospective Cohort Study

Cardiotoxicity in Pediatric Cancer Survivorship: Retrospective Cohort Study

Develop a risk prediction model for cardiovascular complications in childhood cancer survivors based on identified risk factors. Assess the impact of cardiovascular complications on overall survival and quality of life measures in the survivor cohort. Explore potential cardioprotective factors or interventions associated with reduced risk of cardiovascular complications.

Masab Mansoor, Andrew Ibrahim

JMIRx Med 2025;6:e65299

Challenges in Implementing Artificial Intelligence in Breast Cancer Screening Programs: Systematic Review and Framework for Safe Adoption

Challenges in Implementing Artificial Intelligence in Breast Cancer Screening Programs: Systematic Review and Framework for Safe Adoption

Many countries worldwide have embraced mammographic screening programs as a vital tool for identifying breast cancer in its early stages, significantly reducing the risk of associated mortality [2]. Despite the perceived advantages, numerous challenges remain in the interpretation of screening mammograms. First, the high volume of screenings, combined with the requirement for independent, blinded double-reading by radiologists, places significant pressure on the existing radiology workforce [3].

Serene Goh, Rachel Sze Jen Goh, Bryan Chong, Qin Xiang Ng, Gerald Choon Huat Koh, Kee Yuan Ngiam, Mikael Hartman

J Med Internet Res 2025;27:e62941

Application of an Innovative Methodology to Build Infrastructure for Digital Transformation of Health Systems: Developmental Program Evaluation

Application of an Innovative Methodology to Build Infrastructure for Digital Transformation of Health Systems: Developmental Program Evaluation

To address this critical gap in digital health platform development, this study aimed to apply mixed evaluation methods to assess the development of a digital health platform that was exclusively developed by a research and development team working remotely during the COVID-19 pandemic to manage, monitor, and mitigate household risk of COVID-19.

M Claire Buchan, Tarun Reddy Katapally, Jasmin Bhawra

JMIR Form Res 2025;9:e53339

Developing a Machine Learning Model for Predicting 30-Day Major Adverse Cardiac and Cerebrovascular Events in Patients Undergoing Noncardiac Surgery: Retrospective Study

Developing a Machine Learning Model for Predicting 30-Day Major Adverse Cardiac and Cerebrovascular Events in Patients Undergoing Noncardiac Surgery: Retrospective Study

With over 300 million noncardiac surgeries performed annually, accurate preoperative risk assessment has become essential to optimize patient outcomes and reduce health care costs [5,6]. However, the predictive accuracy of traditional assessment tools is not consistently high, and various tools are used at different physicians’ discretion [7].

Ju-Seung Kwun, Houng-Beom Ahn, Si-Hyuck Kang, Sooyoung Yoo, Seok Kim, Wongeun Song, Junho Hyun, Ji Seon Oh, Gakyoung Baek, Jung-Won Suh

J Med Internet Res 2025;27:e66366

Consumer Engagement With Risk Information on Prescription Drug Social Media Pages: Findings From In-Depth Interviews

Consumer Engagement With Risk Information on Prescription Drug Social Media Pages: Findings From In-Depth Interviews

Risk information is also sometimes conveyed in a featured text post, a scrolling video post, a risk information pop-up, or a highlighted story. Many pharmaceutical companies place the risk information in multiple places on their social media pages and posts. However, even when this information is displayed in various locations, UI or UX features of social media platforms may still inhibit consumers’ ability to find, review, and comprehend the risk information.

Jacqueline B Amoozegar, Peyton Williams, Kristen C Giombi, Courtney Richardson, Ella Shenkar, Rebecca L Watkins, Amie C O'Donoghue, Helen W Sullivan

J Med Internet Res 2025;27:e67361