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Effect of Clinic-Based and Asynchronous Video-Based Exercise on Clinic and Psychosocial Outcomes in Patients With Knee Osteoarthritis: Quasi-Experimental Study

Effect of Clinic-Based and Asynchronous Video-Based Exercise on Clinic and Psychosocial Outcomes in Patients With Knee Osteoarthritis: Quasi-Experimental Study

Doi et al [47] conducted a randomized controlled trial involving 142 patients with knee osteoarthritis. They found that a home-based quadriceps strengthening program involving 20 repetitions of a slow knee extension movement implemented 4 times daily for 8 weeks was as effective as nonsteroidal anti-inflammatory drugs for improved pain, stiffness, physical function, and Qo L outcomes.

Chidozie E Mbada, Henry Akintunji Awosika, Oluwatobi Ademola Sonuga, Micheal Akande, Tadesse Gebrye, Richard Woolf, Francis Fatoye

J Med Internet Res 2025;27:e58393

Effectiveness of Continuous Glucose Monitoring on Short-Term, In-Hospital Mortality Among Frail and Critically Ill Patients With COVID-19: Randomized Controlled Trial

Effectiveness of Continuous Glucose Monitoring on Short-Term, In-Hospital Mortality Among Frail and Critically Ill Patients With COVID-19: Randomized Controlled Trial

We thus performed an exploratory, prospective, open-label, parallel, single-center, randomized controlled trial (RCT) to investigate the effectiveness of CGM on short-term, in-hospital mortality among frail and critically ill patients with COVID-19. This is an exploratory, prospective, open-label, parallel, single-center RCT.

Jiawei Shang, Ziming Yuan, Zuoyan Zhang, Quanhong Zhou, Yan Zou, Wei Wang

J Med Internet Res 2025;27:e67012

Role of Tailored Timing and Frequency Prompts on the Efficacy of an Internet-Delivered Stress Recovery Intervention for Health Care Workers: Randomized Controlled Trial

Role of Tailored Timing and Frequency Prompts on the Efficacy of an Internet-Delivered Stress Recovery Intervention for Health Care Workers: Randomized Controlled Trial

In this study, we aimed to test whether the inclusion of tailored prompts aimed at achieving usage goals can increase the efficacy of an ICBT stress recovery intervention for health care workers in a randomized controlled trial (RCT). The “For Recovery from Stress” (FOREST) is a 6-week ICBT intervention [14], incorporating mindfulness and focused on stress recovery [15]. FOREST+ is the updated version of FOREST, designed to meet the needs of health care workers [5].

Auguste Nomeikaite, Odeta Gelezelyte, Maria Böttche, Gerhard Andersson, Evaldas Kazlauskas

JMIR Ment Health 2025;12:e62782

Effect of a Web-Based Heartfulness Program on the Mental Well-Being, Biomarkers, and Gene Expression Profile of Health Care Students: Randomized Controlled Trial

Effect of a Web-Based Heartfulness Program on the Mental Well-Being, Biomarkers, and Gene Expression Profile of Health Care Students: Randomized Controlled Trial

This was a prospective randomized control trial assessing changes in the PSS and DASS-21 scores over a 12-week period. Both are validated questionnaires studied extensively in the literature [26,27]. The PSS consists of 10 items that measure the subjective feelings of the amount of stress in the participants by assessing thoughts and feelings in the previous month. Each question is scored from 0 (never) to 4 (very often) with a total possible score range of 0 to 40.

Jayaram Thimmapuram, Kamlesh D Patel, Deepti Bhatt, Ajay Chauhan, Divya Madhusudhan, Kashyap K Bhatt, Snehal Deshpande, Urvi Budhbhatti, Chaitanya Joshi

JMIR Bioinform Biotech 2024;5:e65506

Internet-Delivered Psychoeducation (SCOPE) for Transition-Aged Autistic Youth: Pragmatic Randomized Controlled Trial

Internet-Delivered Psychoeducation (SCOPE) for Transition-Aged Autistic Youth: Pragmatic Randomized Controlled Trial

In 2015, Gordon et al [18] conducted a randomized controlled trial (RCT) for autistic adolescents and their parents, with low attrition and high satisfaction among participants. Hidalgo et al [19] conducted an open trial for autistic adults and their close relations using group-based psychoeducational intervention, and Crane et al [20] used autistic-led peer groups; both were able to show low attrition as well as high satisfaction with program contents.

Anna Backman, Lise Roll-Pettersson, Are Mellblom, Elisabet Norman-Claesson, Emma Sundqvist, Eric Zander, Sarah Vigerland, Tatja Hirvikoski

J Med Internet Res 2024;26:e49305

Mobile-Based Platform With a Low-Calorie Dietary Intervention Involving Prepackaged Food for Weight Loss for People With Overweight and Obesity in China: Half-Year Follow-Up Results of a Randomized Controlled Trial

Mobile-Based Platform With a Low-Calorie Dietary Intervention Involving Prepackaged Food for Weight Loss for People With Overweight and Obesity in China: Half-Year Follow-Up Results of a Randomized Controlled Trial

We found 1 randomized study focused on the change in body composition during a weight loss intervention in China [12]. However, the sample size was limited, and the body composition results are not sufficiently accurate considering their measuring method; therefore, we still need more reliable evidence on this topic.

Xi Wang, Suyuan Wang, Lingyu Zhong, Chenghui Zhang, Yanhong Guo, Mingxia Li, Li Zhao, Shuming Ji, Junjie Pan, Yunhong Wu

JMIR Mhealth Uhealth 2024;12:e47104

Internet-Based Supportive Interventions for Family Caregivers of People With Dementia: Randomized Controlled Trial

Internet-Based Supportive Interventions for Family Caregivers of People With Dementia: Randomized Controlled Trial

This manuscript presents the findings of a randomized controlled trial examining the implementation of internet-based supportive interventions for home care among patients with dementia in China. The trial is an innovative web-based support program that was developed to advance the skills, knowledge, and practice of caregivers, in order to enhance self-care skills in individuals with dementia and simultaneously provide invaluable assistance to their caregivers.

Yanhong Xie, Shanshan Shen, Caixia Liu, Huilan Guan, Jingmei Zhang, Wanqi Yu, Hong Hong

JMIR Aging 2024;7:e50847

Examining the Feasibility, Acceptability, and Preliminary Efficacy of an Immersive Virtual Reality–Assisted Lower Limb Strength Training for Knee Osteoarthritis: Mixed Methods Pilot Randomized Controlled Trial

Examining the Feasibility, Acceptability, and Preliminary Efficacy of an Immersive Virtual Reality–Assisted Lower Limb Strength Training for Knee Osteoarthritis: Mixed Methods Pilot Randomized Controlled Trial

Quantitative and qualitative data were conducted concurrently in a 12-week, 2-arm, pilot randomized controlled trial design (CHi CTR2100046313). This study was conducted in Hong Kong from June 1, 2021, to March 18, 2022, in 3 separate batches. All collected quantitative and qualitative data were equally weighted, independently analyzed, and then integrated to generate results [26].

Hermione Hin Man Lo, Marques Ng, Pak Yiu Hugo Fong, Harmony Hoi Ki Lai, Bo Wang, Samuel Yeung-shan Wong, Regina Wing Shan Sit

JMIR Serious Games 2024;12:e52563

Efficacy of Digital Dance on Brain Imagery, Cognition, and Health: Randomized Controlled Trial

Efficacy of Digital Dance on Brain Imagery, Cognition, and Health: Randomized Controlled Trial

Hence, this randomized controlled trial (RCT) aimed to study hypothetical benefits of digital somatosensory dance games on structural and functional brain imaging findings, cognitive performance, physical health, and mental health biomarkers. This RCT enrolled community residents aged ≥55 years in Taipei, Taiwan, from August 31, 2020, to June 27, 2021, and followed them for 6 months; however, the trial was interrupted for approximately 3 months due to the COVID-19 pandemic (Figure 1).

Heng-Hsin Tung, Chen-Yuan Kuo, Pei-Lin Lee, Chih-Wen Chang, Kun-Hsien Chou, Ching-Po Lin, Liang-Kung Chen

J Med Internet Res 2024;26:e57694

Effectiveness of a Mobile Phone Messaging–Based Message Framing Intervention for Improving Maternal Health Service Uptake and Newborn Care Practice in Rural Jimma Zone, Ethiopia: Protocol for a Cluster Randomized Controlled Trial

Effectiveness of a Mobile Phone Messaging–Based Message Framing Intervention for Improving Maternal Health Service Uptake and Newborn Care Practice in Rural Jimma Zone, Ethiopia: Protocol for a Cluster Randomized Controlled Trial

A 3-arm, cluster-randomized trial design with a 1:1 allocation ratio was used. The participants in the intervention were assigned to 3 arms: gain-framed, loss-framed, and control. The detailed description of each arm is presented as follows: Women in this arm received an automated gain-framed message.

Gebeyehu Bulcha, Hordofa Gutema Abdissa, Josef Noll, Demisew Amenu Sori, Zewdie Birhanu Koricha

JMIR Res Protoc 2024;13:e52395