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Using Blood Group Genotyping to Predict Hemolysis in Patients With β-Thalassemia Major With Frequent Transfusions: Protocol for a Cross-Sectional Study

Using Blood Group Genotyping to Predict Hemolysis in Patients With β-Thalassemia Major With Frequent Transfusions: Protocol for a Cross-Sectional Study

The homogeneity of donor and recipient populations, RBC phenotype matching policies, and age at transfusion initiation can influence the frequency of alloimmunization, according to research and literature [4,7-9]. The incidence of alloimmunization in thalassemia is reported to range from 4% to 50%, with anti-E, anti-C, and anti-Kell being the most common alloantibodies identified [7,8].

Vitasari Indriani, Teguh Triyono, Budi Mulyono

JMIR Res Protoc 2025;14:e64379

Reliability of Average Daily Steps Measured Through a Consumer Smartwatch in Parkinson Disease Phenotypes, Stages, and Severities: Cross-Sectional Study

Reliability of Average Daily Steps Measured Through a Consumer Smartwatch in Parkinson Disease Phenotypes, Stages, and Severities: Cross-Sectional Study

Nevertheless, no study to date considered disease phenotype, stage, and symptom severity when assessing the reliability of consumer wrist-worn devices for step counting in unsupervised, free-living conditions in mild-to-moderate people with PD. This study was hence specifically designed to address this issue.

Edoardo Bianchini, Domiziana Rinaldi, Lanfranco De Carolis, Silvia Galli, Marika Alborghetti, Clint Hansen, Antonio Suppa, Marco Salvetti, Francesco Ernesto Pontieri, Nicolas Vuillerme

JMIR Form Res 2025;9:e63153

Identifying and Estimating Frailty Phenotypes by Vocal Biomarkers: Cross-Sectional Study

Identifying and Estimating Frailty Phenotypes by Vocal Biomarkers: Cross-Sectional Study

The Mac Arthur Study of Successful Aging captured 2 subdimensions of the CHS phenotype, in which slower gait, weaker grip strength, and lower physical activity define the first component that can better predict cognitive impairment, disability, and mortality, while exhaustion and weight loss define the second component [11].

Yu-Chun Lin, Huang-Ting Yan, Chih-Hsueh Lin, Hen-Hong Chang

J Med Internet Res 2024;26:e58466

Case Identification of Depression in Inpatient Electronic Medical Records: Scoping Review

Case Identification of Depression in Inpatient Electronic Medical Records: Scoping Review

Components we extracted included study characteristics (country, year, and inpatient or outpatient setting), the specific data source and details of the data, and the validation methodology (eg, medical record review), as well as detailed descriptions of the phenotype developed, the methods used, and the purpose for the case definition. We recorded the performance of the developed algorithms as reported in each study.

Allison Grothman, William J Ma, Kendra G Tickner, Elliot A Martin, Danielle A Southern, Hude Quan

JMIR Med Inform 2024;12:e49781

Assessing the Effect of Electronic Health Record Data Quality on Identifying Patients With Type 2 Diabetes: Cross-Sectional Study

Assessing the Effect of Electronic Health Record Data Quality on Identifying Patients With Type 2 Diabetes: Cross-Sectional Study

The following results include the percentage of patients identified by each phenotype while simulating data quality issues using diagnosis codes. Figures S1 to S3 in Multimedia Appendix 1 show the same diagnosis results but depict the frequency of patients identified by each phenotype. Figures S4 to S17 in Multimedia Appendix 1 show results as the percentages and frequencies of patients identified by each phenotype while simulating data quality issues using medication and laboratory data types.

Priyanka Dua Sood, Star Liu, Harold Lehmann, Hadi Kharrazi

JMIR Med Inform 2024;12:e56734

Defining and Risk-Stratifying Immunosuppression (the DESTINIES Study): Protocol for an Electronic Delphi Study

Defining and Risk-Stratifying Immunosuppression (the DESTINIES Study): Protocol for an Electronic Delphi Study

This study aims to obtain clinical consensus on a risk-stratified phenotype of adult “immunosuppression” to be implemented within UK health databases as standard. The use of COVID-19 as our reference condition is justified by pandemic gains to the immunosuppressed literature base [11].

Meredith Leston, José Ordóñez-Mena, Mark Joy, Simon de Lusignan, Richard Hobbs, Iain McInnes, Lennard Lee

JMIR Res Protoc 2024;13:e56271