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Chronic nociplastic pain includes conditions such as irritable bowel syndrome, interstitial cystitis, and the quintessential nociplastic pain condition, fibromyalgia, which alone affects more than 20 million Americans [1]. While the mechanisms underlying nociplastic pain are not completely understood, central nervous system–mediated amplification of pain and other sensory input, along with altered pain modulation, play a major role [2].
JMIR Res Protoc 2025;14:e75060
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conditions, as PT and movement may increase pain and soreness in the short term.
J Med Internet Res 2025;27:e76794
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In the late 1990s, pharmaceutical companies advised the medical community that patients would not become addicted to opioid pain relievers. This led to increased prescription of opioids and widespread misuse of both prescription and illicit opioids before it became clear that these medications could indeed be highly addictive. Although prescription habits have since improved, the mistakes of the past continue to haunt us [2].
JMIR Res Protoc 2025;14:e72317
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Tulgar and Senturk [10] and Tulgar et al [11] have described extensive and long-lasting pain relief after L-ESPB in hip arthroplasty. Conversely, Chan et al [12] found that L-ESPB did not reduce pain or opioid consumption in patients undergoing hip surgery.
Given the lack of high-quality clinical trials evaluating L-ESPB in hip surgery, this study is warranted.
JMIR Res Protoc 2025;14:e75854
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Virtual Reality for Analgesia During Intrauterine Device Insertion: Randomized Controlled Trial
VR has demonstrated moderate benefits in acute pain management, including burns, labor, dressing changes, and periodontal procedures [15]. It is theorized that VR provides distraction from pain by multisensorial stimulation, perhaps via the gated-pain theory [7,14]. Reported side effects of VR are infrequent, mild, and self-limiting. They include nausea, vomiting, and eyestrain, collectively referred to as “cybersickness” [14].
JMIR Serious Games 2025;13:e72917
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Baseline characteristics are reported for demographic variables (sex, age, height, and weight), pain duration, medication use, and current sick leave, as well as for pain intensity (numeric rating scale: 0‐10) and disability (German Oswestry Disability Index: 0‐32 [20]). For this preplanned secondary analysis, we collected data on the usability of the NOLA app and perceptions of patients toward telemedicine in general.
JMIR Form Res 2025;9:e59866
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With the aging population and the cost of chronic pain potentially reaching up to US $635 billion annually [10], VR has also been developed to relieve persistent pain. Studies have validated its efficacy in pain reduction using techniques such as distraction, relaxation, graded exposure therapy, and pain management education [11-14]. Various VR applications have been designed and built specifically for chronic pain therapy.
JMIR Form Res 2025;9:e67765
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Since the commercial availability of a simple immersive VR (i VR) device in 2016, medical applications of i VR have rapidly advanced, demonstrating effectiveness in reducing intractable chronic pain that has not responded to drugs [3] and reducing anxiety in hospitalized patients with breast cancer [4].
J Med Internet Res 2025;27:e65924
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Pain after total joint arthroplasty (TJA) is expected, but little is known about pain after discharge [1]. As the length of hospital stay after surgery continues to decrease, it is essential to develop our knowledge regarding pain and its management in the subacute postoperative phase. A recent meta-analysis found the prevalence of moderate to severe postoperative pain ranges from 51%, one day after discharge, to 58%, 1‐2 weeks after discharge [1].
JMIR Nursing 2025;8:e69010
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Interstitial cystitis/bladder pain syndrome (IC/BPS) is a multifactorial, chronic urinary bladder syndrome. Common symptoms of IC/BPS include dysuria, dyspareunia, urgency, a persistent or recurrent sense of bladder pain or pressure that is often exacerbated as the bladder fills and is temporarily relieved after voiding, frequent urination or with little warning, nocturia that disrupts sleep, and associated burning or other abnormal urinary sensations [1].
JMIR Form Res 2025;9:e70813
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