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Fusion of X-Ray Images and Clinical Data for a Multimodal Deep Learning Prediction Model of Osteoporosis: Algorithm Development and Validation Study

Fusion of X-Ray Images and Clinical Data for a Multimodal Deep Learning Prediction Model of Osteoporosis: Algorithm Development and Validation Study

Osteoporosis is a common metabolic bone disease characterized by decreased bone mineral density (BMD) and thinning of the trabecular structure of bone, leading to fragile bones and an increased risk of fracture. As the global population ages, osteoporosis has become a key factor affecting the health of middle-aged and older adults. However, the early symptoms of osteoporosis are not obvious, and most patients are diagnosed only after a fracture occurs, leading to increased complications and mortality [1].

Jun Tang, Xiang Yin, Jiangyuan Lai, Keyu Luo, Dongdong Wu

JMIR Med Inform 2025;13:e70738


Investigating the Effects of a High-Load Resistance Training Program on Bone Health in Wheelchair Users (the BoneWheel Study): Protocol for a Randomized Controlled Trial

Investigating the Effects of a High-Load Resistance Training Program on Bone Health in Wheelchair Users (the BoneWheel Study): Protocol for a Randomized Controlled Trial

1: Skeletal adaptations to alterations in weight-bearing activity: a comparison of models of disuse osteoporosis Reference 2: The pathophysiology, identification and management of fracture risk, sublesional osteoporosis Reference 6: Position statement: exercise guidelines for osteoporosis management and fall prevention in osteoporosis patientsosteoporosis

Linn Christin Risvang, Vegard Strøm, Jan-Willem van Dijk, Hannah Rice, Øyvind Sandbakk, Lars Peder Bovim, Julia Kathrin Baumgart, Marte Bentzen, Truls Raastad, Kristin L Jonvik

JMIR Res Protoc 2025;14:e70125


Jaw Bone Density in Chronic Areca Nut Chewers and Nonchewers Using Digital Panoramic Radiography Indices as a Screening Tool for Osteoporosis: Protocol for a Comparative Evaluation

Jaw Bone Density in Chronic Areca Nut Chewers and Nonchewers Using Digital Panoramic Radiography Indices as a Screening Tool for Osteoporosis: Protocol for a Comparative Evaluation

Osteoporosis, which affects bone density, is a common finding in women older than 40 years. It can also be seen in men with various diseases affecting the bones or taking medications that affect bone mineral density (BMD). The risk of osteoporosis increases with age and can have deleterious effect on the body. Early detection of this condition may help to halt progression and offer prompt treatment to the patients.

Aakanksha Tiwari, Suwarna Dangore-khasbage

JMIR Res Protoc 2025;14:e72041


Developing and Evaluating an Interactive, Case-Based, Web-Based Active Learning Tool for Primary Care Physicians (Community Fracture Capture Learning Hub): Protocol for an Acceptability and Engagement Study

Developing and Evaluating an Interactive, Case-Based, Web-Based Active Learning Tool for Primary Care Physicians (Community Fracture Capture Learning Hub): Protocol for an Acceptability and Engagement Study

Participating PCPs will complete 4 knowledge quizzes (1 quiz in each of weeks 2-5) and a questionnaire regarding osteoporosis caseload and demographics, confidence in case finding, investigations and treatment initiation, and barriers to osteoporosis case finding, investigations, and treatment initiation.

Ahmed M Fathalla, Cherie Chiang, Ralph Audehm, Alexandra Gorelik, Shanton Chang, Christopher J Yates, Steve Snow, Rahul Barmanray, Sarah Price, Lucy Collins, John D Wark

JMIR Res Protoc 2025;14:e57511


Effectiveness of an e-Book on Bone Health as Educational Material for Adolescents: Single-Group Experimental Study

Effectiveness of an e-Book on Bone Health as Educational Material for Adolescents: Single-Group Experimental Study

Raising osteoporosis awareness among adolescents is important for reducing the risk of the disease later in life [27]. Despite its significance, research on osteoporosis knowledge among adolescents in Malaysia is limited, with such research predominantly focusing on adults and older populations [10,28]. One study highlighted deficiencies in osteoporosis knowledge and engagement in bone health practices among adolescents [29].

Nor Aini Jamil, Jashwiny Dhanaseelan, Nurin Athirah Buhari

JMIR Pediatr Parent 2024;7:e56611


Sex- and Age-Specific Prevalence of Osteopenia and Osteoporosis: Sampling Survey

Sex- and Age-Specific Prevalence of Osteopenia and Osteoporosis: Sampling Survey

The DALY and death count of both osteopenia and osteoporosis-related fractures increased by 121.07% and 148.65%, respectively during the same period, and China is among the top 5 countries with the highest DALYs number in the osteopenia and osteoporosis-related fractures [4]. The risk factors of osteoporosis include family history, abnormal BMI, unhealthy lifestyles, being a woman, and aging [5].

Yao Fan, Qun Li, Yu Liu, Jing Miao, Ting Zhao, Jinxin Cai, Min Liu, Jun Cao, Haifeng Xu, Lai Wei, Mengxia Li, Chong Shen

JMIR Public Health Surveill 2024;10:e48947


Evaluation of an mHealth App on Self-Management of Osteoporosis: Prospective Survey Study

Evaluation of an mHealth App on Self-Management of Osteoporosis: Prospective Survey Study

Osteoporosis ranks as the fourth most prevalent chronic disease globally, carrying substantial negative personal and economic consequences [1]. Osteoporosis affects approximately 40% of women and 17% of men aged 50 years or older. Despite its high prevalence, osteoporosis is significantly underdiagnosed [2].

Magnus Grønlund Bendtsen, Bodil Marie Thuesen Schönwandt, Mette Rubæk, Mette Friberg Hitz

Interact J Med Res 2024;13:e53995


Potential Effects of an Exoskeleton-Assisted Overground Walking Program for Individuals With Spinal Cord Injury Who Uses a Wheelchair on Imaging and Serum Markers of Bone Strength: Pre-Post Study

Potential Effects of an Exoskeleton-Assisted Overground Walking Program for Individuals With Spinal Cord Injury Who Uses a Wheelchair on Imaging and Serum Markers of Bone Strength: Pre-Post Study

This complication, referred to as sublesional osteoporosis, is associated with an increased risk of fracture, notably at the distal femur and proximal tibia [5]. Bone strength is directly related to fracture risk and can be influenced by several characteristics, such as bone mineral density and content, as well as geometry [6]. Measuring areal bone mineral density by dual-energy x-ray absorptiometry (DEXA) remains widely recommended to assess fracture risk in this population [7].

Alec Bass, Suzanne N Morin, Michael Guidea, Jacqueline T A T Lam, Antony D Karelis, Mylène Aubertin-Leheudre, Dany H Gagnon, Montreal Exoskeleton Walking Program (MEWP) Group

JMIR Rehabil Assist Technol 2024;11:e53084


A Machine Learning–Based Preclinical Osteoporosis Screening Tool (POST): Model Development and Validation Study

A Machine Learning–Based Preclinical Osteoporosis Screening Tool (POST): Model Development and Validation Study

Osteoporosis is a systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue, leading to enhanced bone fragility and a consequent increase in fracture risk [1]. Over 200 million people worldwide are affected by osteoporosis [2]. In Hong Kong, about 300,000 postmenopausal women and 100,000 men aged older than 50 years had osteoporosis in 2009, and the number of individuals with low bone mass is expected to double by the year 2030 [3].

Qingling Yang, Huilin Cheng, Jing Qin, Alice Yuen Loke, Fei Wan Ngai, Ka Chun Chong, Dexing Zhang, Yang Gao, Harry Haoxiang Wang, Zhaomin Liu, Chun Hao, Yao Jie Xie

JMIR Aging 2023;6:e46791


Effectiveness and Cost of Using Facebook Recruitment to Elicit Canadian Women’s Perspectives on Bone Health and Osteoporosis: Cross-Sectional Survey Study

Effectiveness and Cost of Using Facebook Recruitment to Elicit Canadian Women’s Perspectives on Bone Health and Osteoporosis: Cross-Sectional Survey Study

Osteoporosis is a prevalent health condition, affecting more than two-thirds of postmenopausal women, with up to half experiencing a fragility fracture [8,9]. However, minimal data are available regarding the perspectives and preferences of Canadian women on the topics of bone health and osteoporosis prevention, limiting efforts to develop acceptable, preference-sensitive management strategies.

Emma Olive Billington, Charley M Hasselaar, Lorena Kembel, Rebecca C Myagishima, Mubashir A Arain

J Med Internet Res 2023;25:e47970