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Neurofeedback Training for Managing Neuropathic Pain–Like Features in Chronic Musculoskeletal Pain: Protocol for an Open-Label Pilot Feasibility Clinical Trial

Neurofeedback Training for Managing Neuropathic Pain–Like Features in Chronic Musculoskeletal Pain: Protocol for an Open-Label Pilot Feasibility Clinical Trial

Chronic musculoskeletal (MSK) pain is the leading cause of disability, affecting over 1.7 billion people globally [1]. In New Zealand, one-quarter of the population is affected by some form of MSK disorder, and one-fifth of the population lives with chronic pain [2,3]. A subgroup of chronic MSK pain exhibits neuropathic pain (NP)-like qualities, which include symptoms such as burning, shocking, shooting, numbness, and “pins and needles” [4-8].

Luke Spencer Bialostocki, Divya Bharatkumar Adhia, Damith Rathnayake Mudiyanselage, Mark Llewellyn Smith, Yusuf Ozgur Cakmak, Dirk De Ridder, Ramakrishnan Mani, Jerin Mathew

JMIR Res Protoc 2025;14:e78806


Assessing the Ability of an Online Education Program to Modify Patient Expectations of Total Knee Arthroplasty Outcomes: Protocol for a Randomized Controlled Trial

Assessing the Ability of an Online Education Program to Modify Patient Expectations of Total Knee Arthroplasty Outcomes: Protocol for a Randomized Controlled Trial

Musculoskeletal health literacy among patients seeking orthopedic care has been found to be lower than general health literacy [38]. While there is a substantial volume of online information regarding TKA, its utility is limited due to poor readability, understandability, and actionability [39]. This is concerning, as low health literacy is associated with patients with musculoskeletal conditions setting lower expectations for surgical outcomes [40-42].

Karen Ribbons, Frederick Rohan Walker, Michael Pollack, Michael Nilsson

JMIR Res Protoc 2025;14:e71898


Capturing Objective Functional Measures Using Smartphone Inertial Sensors: Feasibility and Usability Study With Older Adults

Capturing Objective Functional Measures Using Smartphone Inertial Sensors: Feasibility and Usability Study With Older Adults

This can lead to poor outcomes when patients do not receive adequate support to complete their prescribed physiotherapy for musculoskeletal conditions. Digital platforms and smartphone apps can help patients with musculoskeletal conditions receive targeted interventions and physiotherapy support within their own home [3].

Christian Kempton, Kate Ryan, Sophie Clohessy, Peter Grinbergs, Mark T Elliott

JMIR Rehabil Assist Technol 2025;12:e72511


Associations Between Daily Symptoms and Pain Flares in Rheumatoid Arthritis: Case-Crossover mHealth Study

Associations Between Daily Symptoms and Pain Flares in Rheumatoid Arthritis: Case-Crossover mHealth Study

Individuals with chronic musculoskeletal conditions, such as rheumatoid arthritis (RA), typically experience persistent pain that requires continuous treatment and long-term management. Daily fluctuations in pain are common [6,7]. While not all fluctuations require clinical attention, periods of significantly increased pain severity, known as pain flares, have a greater impact and present clinical challenges due to their variability and unpredictability [8-10].

Ting-Chen Chloe Hsu, Belay B Yimer, Pauline Whelan, Christopher J Armitage, Katie Druce, John McBeth

JMIR Mhealth Uhealth 2025;13:e64889


Machine Learning Clinical Decision Support for Interdisciplinary Multimodal Chronic Musculoskeletal Pain Treatment: Prospective Pilot Study of Patient Assessment and Prognostic Profile Validation

Machine Learning Clinical Decision Support for Interdisciplinary Multimodal Chronic Musculoskeletal Pain Treatment: Prospective Pilot Study of Patient Assessment and Prognostic Profile Validation

Chronic musculoskeletal pain (CMP) is a prevalent and debilitating condition that significantly impacts the quality of life for millions of individuals worldwide [1]. Patients with CMP often experience long-term pain, where all available treatments have been ineffective, resulting in debilitating pain; fatigue; limited mobility; and associated reduced social activity, employment, and quality of life.

Fredrick Zmudzki, Rob J E M Smeets, Jan S Groenewegen, Erik van der Graaff

JMIR Rehabil Assist Technol 2025;12:e65890


Improving Safety, Efficiency, Cost, and Satisfaction Across a Musculoskeletal Pathway Using the Digital Assessment Routing Tool for Triage: Quality Improvement Study

Improving Safety, Efficiency, Cost, and Satisfaction Across a Musculoskeletal Pathway Using the Digital Assessment Routing Tool for Triage: Quality Improvement Study

Musculoskeletal (MSK) conditions are prevalent and increasing, associated with an aging population and reducing levels of physical activity in Western-style economies [2,3]. They pose a financial and societal challenge, with the cost to the UK National Health Service (NHS) estimated at £6.3 billion (US $8.26 billion) in 2022-2023 [4].

Cabella Lowe, Laura Atherton, Peter Lloyd, Anna Waters, Dylan Morrissey

J Med Internet Res 2025;27:e67269


Identifying Patient-Reported Outcome Measure Documentation in Veterans Health Administration Chiropractic Clinic Notes: Natural Language Processing Analysis

Identifying Patient-Reported Outcome Measure Documentation in Veterans Health Administration Chiropractic Clinic Notes: Natural Language Processing Analysis

Measurement-based care is a recommended practice in the management of musculoskeletal pain conditions [2], where biomarkers of disease severity are lacking and baseline and serial reassessment for progress may influence clinical decision-making. Using PROMs can improve communication and shared decision-making between patients and clinicians, enable contextualization of pain within a patient’s life, and may positively influence health and pain status [3].

Brian C Coleman, Kelsey L Corcoran, Cynthia A Brandt, Joseph L Goulet, Stephen L Luther, Anthony J Lisi

JMIR Med Inform 2025;13:e66466


Effect of Clinic-Based and Asynchronous Video-Based Exercise on Clinic and Psychosocial Outcomes in Patients With Knee Osteoarthritis: Quasi-Experimental Study

Effect of Clinic-Based and Asynchronous Video-Based Exercise on Clinic and Psychosocial Outcomes in Patients With Knee Osteoarthritis: Quasi-Experimental Study

Osteoarthritis of the knee is a prevalent musculoskeletal condition affecting older people, often accompanied by pain, physical disability, and reduced quality of life (Qo L), with considerable economic burden on the health care system [10,11]. Research indicates that knee osteoarthritis occurs earlier in life, affecting younger adults more often than in previous years, likely due to increased obesity and joint injury [12].

Chidozie E Mbada, Henry Akintunji Awosika, Oluwatobi Ademola Sonuga, Micheal Akande, Tadesse Gebrye, Richard Woolf, Francis Fatoye

J Med Internet Res 2025;27:e58393


Kinetic Pattern Recognition in Home-Based Knee Rehabilitation Using Machine Learning Clustering Methods on the Slider Digital Physiotherapy Device: Prospective Observational Study

Kinetic Pattern Recognition in Home-Based Knee Rehabilitation Using Machine Learning Clustering Methods on the Slider Digital Physiotherapy Device: Prospective Observational Study

This is particularly useful in postoperative rehabilitation or in monitoring the progress of participants with musculoskeletal disorders. For a theoretical application in a clinical setting, cluster characterized by limited range and lower force output might indicate participants who are either in the early stages of recovery from injury or surgery or who are experiencing complications or poor recovery.

Clement Twumasi, Mikail Aktas, Nicholas Santoni

JMIR Form Res 2025;9:e69150


Cutaneous Atrophy Following Corticosteroid Injections for Tendonitis: Report of Two Cases

Cutaneous Atrophy Following Corticosteroid Injections for Tendonitis: Report of Two Cases

Injectable corticosteroids are commonly used to treat musculoskeletal conditions, including tendonitis [1]. Common adverse reactions to corticosteroid injections include atrophy, depigmentation, and cellulitis [1]. Skin depigmentation is a well-recognized adverse effect of corticosteroid injections, but atrophy is underrecognized. Atrophy typically manifests 2-4 months following the injection but may be delayed up to a year [2].

Rebecca Colwell, Mitchell Gullickson, Jonathan Cutlan, Erik Stratman

JMIR Dermatol 2025;8:e67921