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Augmenting Engagement in Decentralized Clinical Trials for Atrial Fibrillation: Development and Implementation of a Programmatic Architecture

Augmenting Engagement in Decentralized Clinical Trials for Atrial Fibrillation: Development and Implementation of a Programmatic Architecture

Summary of assessments at trial time points (baseline 4, 8, and 12 months) in both randomized clinical trials. a AF therapies: pharmacologic or electrical cardioversion, electrophysiologic procedure such as pulmonary vein isolation, or initiation of antiarrhythmic medication. b AF: atrial fibrillation. c PHQ-8: Patient Health Questionnaire. d PROMIS: Patient-reported Outcomes Measurement Information System. e AFEQT: AF Effect on Quality of life.

Toluwa Daniel Omole, Andrew Mrkva, Danielle Ferry, Erin Shepherd, Jessica Caratelli, Noah Davis, Richmond Akatue, Timothy Bickmore, Michael K Paasche-Orlow, Jared W Magnani

JMIR Cardio 2025;9:e66436

The Prevalence and Incidence of Suicidal Thoughts and Behavior in a Smartphone-Delivered Treatment Trial for Body Dysmorphic Disorder: Cohort Study

The Prevalence and Incidence of Suicidal Thoughts and Behavior in a Smartphone-Delivered Treatment Trial for Body Dysmorphic Disorder: Cohort Study

Individuals were excluded if they were currently in therapy, had previously completed 4 or more sessions of CBT for BDD, had undergone psychotropic medication changes less than 2 months before starting the study, reported acute and active suicidal ideation (refer to “Procedures Used for Mitigating Clinical Deterioration and Suicide Risk” section below), or were unable to engage with the smartphone treatment.

Adam C Jaroszewski, Natasha Bailen, Simay I Ipek, Jennifer L Greenberg, Susanne S Hoeppner, Hilary Weingarden, Ivar Snorrason, Sabine Wilhelm

JMIR Ment Health 2025;12:e63605

Adapting a Text Messaging Intervention to Improve Diabetes Medication Adherence in a Spanish-Speaking Population: Qualitative Study

Adapting a Text Messaging Intervention to Improve Diabetes Medication Adherence in a Spanish-Speaking Population: Qualitative Study

While interventions that address patient-reported barriers to diabetes medication adherence can improve glycemic management [20,21], interventions that address barriers to diabetes medication adherence of relevance to Latino adults with T2 D are lacking.

Jacqueline Seiglie, Seth Tobolsky, Ricaurte Crespo Trevino, Lluvia Cordova, Sara Cromer, A Enrique Caballero, Margarita Alegria, J Jaime Miranda, Deborah Wexler, Lindsay Mayberry

JMIR Hum Factors 2025;12:e66668

The Efficacy of Digital Interventions on Adherence to Oral Systemic Anticancer Therapy Among Patients With Cancer: Systematic Review and Meta-Analysis

The Efficacy of Digital Interventions on Adherence to Oral Systemic Anticancer Therapy Among Patients With Cancer: Systematic Review and Meta-Analysis

Adherence measures such as: Medication possession ratio Proportion of days covered Self-reported adherence measures (eg, questionnaires and surveys) Pharmacy refill data Medication event monitoring systems (eg, smart pill bottles and electronic pill caps) Biological markers The study does not contain outcome measures related to adherence. Adherence measures are based solely on subjective reporting (unless validated self-reported measures were used).

Wan-Chuen Liao, Fiona Angus, Jane Conley, Li-Chia Chen

JMIR Cancer 2025;11:e64208

Identification of Patients With Congestive Heart Failure From the Electronic Health Records of Two Hospitals: Retrospective Study

Identification of Patients With Congestive Heart Failure From the Electronic Health Records of Two Hospitals: Retrospective Study

For false positives, reasons included patients with symptoms typical for CHF who had not been given a formal diagnosis of CHF, patients with a family medical history of CHF, cases where negation was expressed unusually (eg, “I do not feel like this is consistent with congestive heart failure”), and notes that had templated preoperative instructions or medication descriptions (eg, “tell your doctor if you have CHF”).

Daniel Sumsion, Elijah Davis, Marta Fernandes, Ruoqi Wei, Rebecca Milde, Jet Malou Veltink, Wan-Yee Kong, Yiwen Xiong, Samvrit Rao, Tara Westover, Lydia Petersen, Niels Turley, Arjun Singh, Stephanie Buss, Shibani Mukerji, Sahar Zafar, Sudeshna Das, Valdery Moura Junior, Manohar Ghanta, Aditya Gupta, Jennifer Kim, Katie Stone, Emmanuel Mignot, Dennis Hwang, Lynn Marie Trotti, Gari D Clifford, Umakanth Katwa, Robert Thomas, M Brandon Westover, Haoqi Sun

JMIR Med Inform 2025;13:e64113

Integrating Virtual Reality, Neurofeedback, and Cognitive Behavioral Therapy for Auditory Verbal Hallucinations (Hybrid): Protocol of a Pilot, Unblinded, Single-Arm Interventional Study

Integrating Virtual Reality, Neurofeedback, and Cognitive Behavioral Therapy for Auditory Verbal Hallucinations (Hybrid): Protocol of a Pilot, Unblinded, Single-Arm Interventional Study

First, the efficacy of antipsychotic medication for the treatment of positive symptoms of psychosis is not optimal. For example, while commonly prescribed antipsychotics can be significantly more effective than placebo, these medications are accompanied by side effects such as weight gain, sedation, and extrapyramidal symptoms which lead to high incidences of patient nonadherence [2].

Jessica Spark, Elise Rowe, Mario Alvarez-Jimenez, Imogen Bell, Linda Byrne, Ilvana Dzafic, Carli Ellinghaus, Suzie Lavoie, Jarrad Lum, Brooke McLean, Neil Thomas, Andrew Thompson, Greg Wadley, Thomas Whitford, Stephen Wood, Hok Pan Yuen, Barnaby Nelson

JMIR Res Protoc 2025;14:e63405

Evaluation of the Clinical Nursing Effects of a Traditional Chinese Medicine Nursing Program Based on Care Pathways for Patients With Type 2 Diabetes: Protocol for a Randomized Controlled Clinical Trial

Evaluation of the Clinical Nursing Effects of a Traditional Chinese Medicine Nursing Program Based on Care Pathways for Patients With Type 2 Diabetes: Protocol for a Randomized Controlled Clinical Trial

We expect that the findings of this study will provide robust evidence for delivering personalized care, standardizing procedures, improving patients’ quality of life, and enhancing self-care and medication adherence after discharge. The intervention protocol for this study is titled “TCM Nursing Protocol for Type 2 Diabetes Based on Care Pathway.”

Yanchun Zhao, Ting Huang, Yanli Chen, Songmei Li, Juan Zhao, Xu Han, Qing Ni, Ning Su

JMIR Res Protoc 2025;14:e58951

Perspectives on and Experiences With Remote Monitoring and Patient-Initiated Care Among Norwegian Patients With Axial Spondyloarthritis: Qualitative Study

Perspectives on and Experiences With Remote Monitoring and Patient-Initiated Care Among Norwegian Patients With Axial Spondyloarthritis: Qualitative Study

Receiving the appropriate diagnosis and treatment with biological medication proved to be life-changing alleviating most of their symptoms. Consequently, for most of the participants, the disease no longer had a significant impact on their daily activities, except for the necessity of having to take medication. However, some of the patients experienced more challenges such as sleep deprivation and fatigue, affecting their daily lives and, in certain instances, their ability to work.

Christine Hillestad Hestevik, Cecilie Varsi, Nina Østerås, Anne Therese Tveter, Jon Skandsen, Hedda Eik

J Med Internet Res 2025;27:e63569

Glucagon-Like Peptide-1 Receptor Agonists Combined With Personalized Digital Health Care for the Treatment of Metabolic Syndrome in Adults With Obesity: Retrospective Observational Study

Glucagon-Like Peptide-1 Receptor Agonists Combined With Personalized Digital Health Care for the Treatment of Metabolic Syndrome in Adults With Obesity: Retrospective Observational Study

Patients’ gender, age, ethnicity, medication, WC (cm), weight kg, BP (mm Hg), and BMI (kg/m²) variables were collected. Laboratory variables were collected including total cholesterol (mg/d L), LDL cholesterol (mg/d L), HDL cholesterol (mg/d L), triglycerides (mg/d L), and fasting glucose (mg/d L). Engagement interactions were collected from the app portal.

Hala Zakaria, Hadoun Jabri, Sheikha Alshehhi, Milena Caccelli, Joelle Debs, Yousef Said, Joudy Kattan, Noah Almarzooqi, Ali Hashemi, Ihsan Almarzooqi

Interact J Med Res 2025;14:e63079