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Sarcopenia and Risk of Cognitive Impairment: Cohort Study and Mendelian Randomization Analysis

Sarcopenia and Risk of Cognitive Impairment: Cohort Study and Mendelian Randomization Analysis

Subsequently, we further used MR mediation analysis to examine the degree to which 11 putative mediators (ie, omega-3 fatty acids, vitamin D levels, physical inactivity, falls, frailty, sleep disorders, anxiety, depression, stroke, metabolic syndrome, and type 2 diabetes) may impact the effects of sarcopenia, to identify potential intervention targets in the causal pathway.

Tingting Sha, Yuqing Zhang, Jie Wei, Changjun Li, Chao Zeng, Guanghua Lei, Yilun Wang

JMIR Aging 2025;8:e66031

Cyberchondria in Older Adults and Its Relationship With Cognitive Fusion, Health-Related Quality of Life, and Mental Well-Being: Mediation Analysis

Cyberchondria in Older Adults and Its Relationship With Cognitive Fusion, Health-Related Quality of Life, and Mental Well-Being: Mediation Analysis

We used structural equation modeling (SEM) with full-information likelihood estimation to assess the hypothesized mediation model. Latent variables for cyberchondria (CSS-12), HRQOL (EQ-5 D-5 L), mental well-being (WHO-5), and cognitive fusion (CFQ) were created based on the sum score of the 4 instruments. Respondents’ characteristics (ie, sex, age, education level, and presence of a chronic condition) were included in the model for adjustment.

Richard Huan Xu, Vladan Starcevic

JMIR Aging 2025;8:e70302

Smartphone-Based Intervention Targeting Norms and Risk Perception Among University Students with Unhealthy Alcohol Use: Secondary Mediation Analysis of a Randomized Controlled Trial

Smartphone-Based Intervention Targeting Norms and Risk Perception Among University Students with Unhealthy Alcohol Use: Secondary Mediation Analysis of a Randomized Controlled Trial

Thus, our secondary hypothesis was that mediation through norms perception would primarily occur among individuals who overestimate other people’s drinking (ie, moderated mediation). To the best of our knowledge, this is the first study to assess moderated mediation in such a setting. This manuscript adheres to the recommendations outlined in A Guideline for Reporting Mediation Analyses (AGRe MA) [46].

Joseph Studer, John A Cunningham, Elodie Schmutz, Jacques Gaume, Angéline Adam, Jean-Bernard Daeppen, Nicolas Bertholet

J Med Internet Res 2025;27:e55541

Using Digital Art and Attachment Priming in a Web-Based Serious Game to Reduce Pain and Social Disconnection in Individuals With Chronic Pain and Loneliness: Randomized Controlled Trial

Using Digital Art and Attachment Priming in a Web-Based Serious Game to Reduce Pain and Social Disconnection in Individuals With Chronic Pain and Loneliness: Randomized Controlled Trial

The data were also analyzed with the Process Macro Model 59 for multicategorical moderated mediation tests to account for the effect of a single moderator on all 3 mediation pathways [52]. Six multicategorical moderated mediation models were constructed to assess the main and interaction effects of the artwork and priming manipulations. The hanging control condition was set as the reference group. Postexperiment pain scores and social disconnection scores were the outcome variables.

Jorge Peña, Ian Koebner, William Weisman

JMIR Serious Games 2024;12:e52294

Association Between Internet Gaming Disorder and Suicidal Ideation Mediated by Psychosocial Resources and Psychosocial Problems Among Adolescent Internet Gamers in China: Cross-Sectional Study

Association Between Internet Gaming Disorder and Suicidal Ideation Mediated by Psychosocial Resources and Psychosocial Problems Among Adolescent Internet Gamers in China: Cross-Sectional Study

In addition, there is further support for the above-proposed mediation. First, pathological internet use (including IGD) has been postulated to cause deficient face-to-face social interactions that would lead to social isolation [20,21]. Longitudinal studies have also reported that adolescent IGD predicted social anxiety and loneliness [22,23].

Yanqiu Yu, Anise M S Wu, Vivian W I Fong, Jianxin Zhang, Ji-bin Li, Joseph T F Lau

JMIR Serious Games 2024;12:e48439

The Association Between Personality Traits and Health-Related Quality of Life and the Mediating Role of Smoking: Nationwide Cross-Sectional Study

The Association Between Personality Traits and Health-Related Quality of Life and the Mediating Role of Smoking: Nationwide Cross-Sectional Study

The Sobel-Goodman mediation test was used to examine the impact of smoking on Big Five personality traits and HRQOL while taking into account all covariates [43]. Statistical significance was determined using 2-sided P values, with α The sample analyzed in this study consisted of 21,916 cases. There was an equal distribution of sexes, with 10,958 (50%) participants identifying as male and 10,958 (50%) identifying as female.

Jiangyun Chen, Jiahuan Wan, Yibo Wu, Li Gan, Haomiao Li, Yan Zhou, Siyuan Liu, Lan Luo, Haozheng Zhou, Xuanhao Yin, Jinghui Chang

JMIR Public Health Surveill 2024;10:e51416

Exploring Relations Between Unique Patient Characteristics and Virtual Reality Immersion Level on Anxiety and Pain in Patients Undergoing Venipuncture: Secondary Analysis of a Randomized Control Trial

Exploring Relations Between Unique Patient Characteristics and Virtual Reality Immersion Level on Anxiety and Pain in Patients Undergoing Venipuncture: Secondary Analysis of a Randomized Control Trial

Conditional process analysis was used for the moderation and mediation analyses [45]. Separate models were run for the proposed mediation and moderation effects of child characteristics (age, gender, procedure location, and anxiety sensitivity) and level of immersion on the outcomes of postprocedural anxiety VAS and pain FPS-R. All models were controlled for preprocedural pain or anxiety.

Jeffrey I Gold, Krystal M Akbar, Sandra Avila, Nhat H Ngo, Margaret J Klein

J Med Internet Res 2024;26:e53196

Predicting COVID-19 Vaccination Uptake Using a Small and Interpretable Set of Judgment and Demographic Variables: Cross-Sectional Cognitive Science Study

Predicting COVID-19 Vaccination Uptake Using a Small and Interpretable Set of Judgment and Demographic Variables: Cross-Sectional Cognitive Science Study

For primary mediations, age significantly mediated the statistical relationship between 11 judgment variables and vaccine uptake (α For the secondary mediation analyses, 5 judgment variables mediated the statistical relationship between age and vaccine uptake; these variables overlapped with the 11 findings of the primary mediation analyses.

Nicole L Vike, Sumra Bari, Leandros Stefanopoulos, Shamal Lalvani, Byoung Woo Kim, Nicos Maglaveras, Martin Block, Hans C Breiter, Aggelos K Katsaggelos

JMIR Public Health Surveill 2024;10:e47979

The Mediating Role of General and Cognitive Stress on the Effect of an App-Based Intervention on Productivity Measures in Workers: Randomized Controlled Trial

The Mediating Role of General and Cognitive Stress on the Effect of an App-Based Intervention on Productivity Measures in Workers: Randomized Controlled Trial

Data were analyzed using the statistical programming language R [43] in combination with the nlme package [44] and the mediate package for the mediation analyses [45]. As both the mediator and the outcome model were linear models, the results obtained by the function are analogous to the usual linear structural equation method described by Baron and Kenny [45,46].

Carlota de Miquel, Maria Victoria Moneta, Silvana Weber, Christopher Lorenz, Beatriz Olaya, Josep Maria Haro

J Med Internet Res 2023;25:e42317