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Skip search results from other journals and go to results- 4 JMIRx Med
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The study uses bioinformatics to compare chromosome breakpoints in breast cancer to those in cancers known to be caused by EBV. The results show that EBV might play a role in breast cancer by damaging important cell functions.
The methods section needs more details about how the datasets were chosen and combined.
The discussion should explain more about how EBV might cause the chromosome breaks and rearrangements seen in breast cancer.
JMIRx Med 2025;6:e70041
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The other contradictory result posits an imperfect palindrome on chromosome 11. This result is tested on page 13.
The implications of these findings are profound but need clearer articulation. Discuss the potential impact on breast cancer treatment and prevention strategies. Also, outline future research directions, particularly in clinical or experimental studies to confirm these bioinformatics findings.
JMIRx Med 2025;6:e69307
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No breaks in 114 liver cancers on chromosome 1 were within 5000 bp of breaks in any NPC; only one break on chromosome 6 in 61 liver cancers fit this window. According to a meta-analysis, the chance that breakpoints on chromosomes 1, 2, 6, and 8 were not within 5000 bp in liver cancer versus NPC was 4.4 (95% CI 1.9‐10).
JMIRx Med 2025;6:e50712
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Effect of Physical Exercise on Telomere Length: Umbrella Review and Meta-Analysis
Typically composed of a repetitive guanine-rich sequence extending from the chromosome end in the 5’ to 3’ orientation, paired with a complementary cytidine-rich strand [5], telomeres exhibit variations in sequence among species, yet share a common repetitive pattern across organisms. Measuring around 15 kilobases at birth in human somatic cells, telomeres undergo gradual attrition, with approximately 25 to 200 bases lost from their ends during each cell division in the absence of telomerase [6].
JMIR Aging 2025;8:e64539
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