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Exploring the Application of AI and Extended Reality Technologies in Metaverse-Driven Mental Health Solutions: Scoping Review

Exploring the Application of AI and Extended Reality Technologies in Metaverse-Driven Mental Health Solutions: Scoping Review

Notably, metaverse-based clinics and virtual reality (VR) teletherapy rooms are now being explored as accessible alternatives to traditional clinical settings [5,6]. XR serves as a gateway to the metaverse, encompassing immersive technologies such as VR, augmented reality (AR), and mixed reality (MR). Each of these modalities offers distinct capabilities.

Aliya Tabassum, Ibrahim Ghaznavi, Alaa Abd-Alrazaq, Junaid Qadir

J Med Internet Res 2025;27:e72400


Feasibility and Efficacy of Commercial-Off-the-Shelf Virtual Reality Applications for Managing Chronic Pain and Enhancing Well-Being Among Older Adults in the Community: Mixed Methods Pilot Study

Feasibility and Efficacy of Commercial-Off-the-Shelf Virtual Reality Applications for Managing Chronic Pain and Enhancing Well-Being Among Older Adults in the Community: Mixed Methods Pilot Study

Since Ivan Sutherland and Bob Sproull created the first virtual reality (VR) headset in 1968, VR technology has evolved significantly [1]. VR involves experiencing digital simulations, ranging from realistic to fantastical, in 3 D spaces using computer technology [2]. Users can experience VR in immersive and nonimmersive forms. Today, VR technology is widely used in gaming, entertainment, education, and therapy.

Rachel Yim Fong Leung, Megan Zichen Ye, Flora Yaqian Zhang, Tyrone Tai-On Kwok, Yuying Sun, Agnes Yuen Kwan Lai, Juming Jiang, Mimi Mun Yee Tse

JMIR Form Res 2025;9:e67765


A Virtual Reality Force Control Training System on Brain Activation: Functional Near-Infrared Spectroscopy (fNIRS) Study

A Virtual Reality Force Control Training System on Brain Activation: Functional Near-Infrared Spectroscopy (fNIRS) Study

Some notable examples of VR-based rehabilitation system that incorporate the VR features are the Amadeo hand rehabilitation device (Tyromotion Gmb H) and the lab custom Tipr device. The Amadeo device is an interactive robotic device for hand function assessment, range of motion exercises, and force control rehabilitation.

Luigi Gan, Chien-Ju Lin, Hsiao-Feng Chieh, Kai-Nan An, Fong-Chin Su

JMIR Serious Games 2025;13:e63874


Knowledge Gain and the Impact of Stress in a Fully Immersive Virtual Reality–Based Medical Emergencies Training With Automated Feedback: Randomized Controlled Trial

Knowledge Gain and the Impact of Stress in a Fully Immersive Virtual Reality–Based Medical Emergencies Training With Automated Feedback: Randomized Controlled Trial

Evidence strongly supports the notion that VR increases learner motivation and improves the contextualization of the learning experience [17]. In a recent research project of ours, we explored different types of perceived stress encountered during VR-based training in medical emergencies [13].

Marco Lindner, Tobias Leutritz, Joy Backhaus, Sarah König, Tobias Mühling

J Med Internet Res 2025;27:e67412


Using Virtual Reality to Enhance Surgical Skills and Engagement in Orthopedic Education: Systematic Review and Meta-Analysis

Using Virtual Reality to Enhance Surgical Skills and Engagement in Orthopedic Education: Systematic Review and Meta-Analysis

Hence, there is still some controversy over whether VR teaching is appropriate in orthopedic education. This paper aims to explore the relationship between VR education and traditional education, as well as their interactive influences. Through meta-analysis and literature review, we will examine the advantages, challenges, and potential of VR education from multiple perspectives.

Ting Li, Jingxin Yan, Xin Gao, Hangyu Liu, Jin Li, Yuanting Shang, Xiaoyu Tang

J Med Internet Res 2025;27:e70266


Factors Influencing Virtual Reality as a Distraction Tool for Venipuncture in Children: Observational Pilot Feasibility Study

Factors Influencing Virtual Reality as a Distraction Tool for Venipuncture in Children: Observational Pilot Feasibility Study

Virtual reality (VR) is a relatively new technology that is increasingly used as a distraction tool due to its immersive nature and capacity to engage multiple senses simultaneously [1]. VR utilizes the notion that attention is finite and can be diverted from pain and discomfort and therefore serves as effective cognitive distraction [2]. VR provides immersive engagement, isolating users from the real-world environment and associated pain and anxiety [1].

Chris Worth, Leyi Yang, Catherine Fullwood, Indraneel Banerjee

JMIR Serious Games 2025;13:e66656


Testing an Innovative Gait Training Program in Immersive Virtual Reality for Healthy Older Adults: Protocol for a Randomized Controlled Trial

Testing an Innovative Gait Training Program in Immersive Virtual Reality for Healthy Older Adults: Protocol for a Randomized Controlled Trial

In the VR condition, participants wore a VR-HMD displaying 2 VEs: a replica of the real one and a new environment. The authors demonstrated the similarity of the gait adaptability behavior produced in the real world and in VR.

Nicolas Mascret, Lisa Delbes, Cédric Goulon, Gilles Montagne

JMIR Res Protoc 2025;14:e57866


Measuring Stress and Perceptions for a Virtual Reality–Based Pericardiocentesis Procedure Simulation for Medical Training: Usability Study

Measuring Stress and Perceptions for a Virtual Reality–Based Pericardiocentesis Procedure Simulation for Medical Training: Usability Study

Virtual reality (VR) has rapidly emerged as a transformative tool in medical education. Its ability to simulate high-risk procedures in a controlled and safe environment has made VR an invaluable resource for developing essential clinical skills [1].

Alberto Rubio-López, Rodrigo García Carmona, Laura Zarandieta Román, Alejandro Rubio Navas, Angel González-Pinto, Pablo Cardinal-Fernández

JMIR Serious Games 2025;13:e68515


Effect of Immersive Virtual Reality Teamwork Training on Safety Behaviors During Surgical Cases: Nonrandomized Intervention Versus Controlled Pilot Study

Effect of Immersive Virtual Reality Teamwork Training on Safety Behaviors During Surgical Cases: Nonrandomized Intervention Versus Controlled Pilot Study

Virtual reality (VR) is a digital technology that enables a virtual manifestation of the real world [11]. VR provides a more captivating experience compared to viewing a conventional video, as it fully envelopes the viewer within the narrative [12]. In VR, the audience becomes an integral part of the story rather than merely an onlooker.

Lukasz Mazur, Logan Butler, Cody Mitchell, Shaian Lashani, Shawna Buchanan, Christi Fenison, Karthik Adapa, Xianming Tan, Selina An, Jin Ra

JMIR Med Educ 2025;11:e66186