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Performance of Machine Learning in Diagnosing KRAS (Kirsten Rat Sarcoma) Mutations in Colorectal Cancer: Systematic Review and Meta-Analysis

Performance of Machine Learning in Diagnosing KRAS (Kirsten Rat Sarcoma) Mutations in Colorectal Cancer: Systematic Review and Meta-Analysis

This study was undertaken as per the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses, 2020) guidelines and has been prospectively registered on the PROSPERO (International Prospective Register of Systematic Reviews) platform (CRD42025610919) [22]. The inclusion criteria were as follows: Studies involving patients diagnosed with CRC; Case-control, cohort, and cross-sectional studies about study designs; An ML model was well constructed to differentiate KRAS mutation status.

Kaixin Chen, Yin Qu, Ye Han, Yan Li, Huiyan Gao, De Zheng

J Med Internet Res 2025;27:e73528

Home-Based Virtual Reality Training for Enhanced Balance, Strength, and Mobility Among Older Adults With Frailty: Systematic Review and Meta-Analysis

Home-Based Virtual Reality Training for Enhanced Balance, Strength, and Mobility Among Older Adults With Frailty: Systematic Review and Meta-Analysis

The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines were followed for this review. The PRISMA item checklist can be found in Checklist 1. The search time frame was from inception to November 1, 2023. The goal was to identify recent studies on the effects of VR training for enhanced balance, strength, and mobility at home among older adults with frailty and prefrailty.

Hammad Alhasan, Elaf Alandijani, Lara Bahamdan, Ghofran Khudary, Yara Aburaya, Abdulaziz Awali, Mansour Abdullah Alshehri

JMIR Serious Games 2025;13:e67146

Effectiveness of Gamified Teaching in Disaster Nursing Education for Health Care Workers: Systematic Review

Effectiveness of Gamified Teaching in Disaster Nursing Education for Health Care Workers: Systematic Review

The quantitative studies were systematically evaluated following the Cochrane Handbook for Systematic Reviews of Interventions, and the report adhered to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines [19]. The study protocol was preregistered on PROSPERO (CRD420250652129) [20]. Ethical approval and informed consent were not necessary, as this study did not include individual patient data.

Shiyi Bai, HuiJuan Zeng, Qianmei Zhong, Lulu Cao, Mei He

J Med Internet Res 2025;27:e74955

Clinical and Cost-Effectiveness of Telehealth-Supported Home Oxygen Therapy on Adherence, Hospital Readmission, and Health-Related Quality of Life in Patients With Chronic Obstructive Pulmonary Disease: Systematic Review and Meta-Analysis of Randomized Controlled Trials

Clinical and Cost-Effectiveness of Telehealth-Supported Home Oxygen Therapy on Adherence, Hospital Readmission, and Health-Related Quality of Life in Patients With Chronic Obstructive Pulmonary Disease: Systematic Review and Meta-Analysis of Randomized Controlled Trials

This review adhered to the guidelines set out in the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) 2020 statement (Checklist 1) and was registered in PROSPERO (CRD42024598539) [18]. We extensively searched 6 electronic databases: Pub Med, Cochrane Central Register of Controlled Trials, Embase, Web of Science, Psyc INFO (via EBSCO), and CINAHL (via EBSCO). This search spanned from the databases’ inception until October 1, 2024.

Cuirong Hu, Xinqi Liao, Yi Fang, Shu Zhu, Xia Lan, Guilan Cheng

J Med Internet Res 2025;27:e73010

Effectiveness of Digital Health Interventions on Sedentary Behavior Among Patients With Chronic Diseases: Systematic Review and Meta-Analysis

Effectiveness of Digital Health Interventions on Sedentary Behavior Among Patients With Chronic Diseases: Systematic Review and Meta-Analysis

The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement was followed in conducting the review (Checklist 1) [26]. The PICOS (Population, Intervention, Control, Outcome, and Study) framework was used to select eligible studies. The population included adults diagnosed with chronic diseases in terms of cardiovascular disease, chronic respiratory disease, cancer, diabetes, metabolic syndrome (Met S), obesity, RA, stroke, and other chronic conditions defined by the WHO [27].

Yan Zhang, Fei Wan Ngai, Qingling Yang, Yao Jie Xie

JMIR Mhealth Uhealth 2025;13:e59943

Effects of Remote Web-Based Interventions on the Physiological and Psychological States of Patients With Cancer: Systematic Review With Meta-Analysis

Effects of Remote Web-Based Interventions on the Physiological and Psychological States of Patients With Cancer: Systematic Review With Meta-Analysis

This systematic review and meta-analysis was registered in PROSPERO (CRD42024611768), and the study was reported following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines (Multimedia Appendix 1) [34]. We conducted electronic literature searches in Pub Med, Scopus, Web of Science, Cochrane Library, CINAHL, and EMBASE from the inception of each database to October 15, 2024. The search terms consisted of subject headings and free terms.

Lv Tian, Yixuan Wen, Jingmiao Li, Jiexin Guan, Tao Li, Jun Fan

JMIR Mhealth Uhealth 2025;13:e71196

Effectiveness of Robot-Assisted Upper Extremity Function Training (Gloreha) on Upper Extremities Function After Stroke: Systematic Review

Effectiveness of Robot-Assisted Upper Extremity Function Training (Gloreha) on Upper Extremities Function After Stroke: Systematic Review

This systematic review was reported according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement [23] (Checklist 1). The study protocol received exempt approval from the Ethics Committee, Faculty of Associated Medical Sciences, Chiang Mai University.

Chirathip Thawisuk, Sopida Apichai, Waranya Chingchit, Jananya P Dhippayom, Teerapon Dhippayom

JMIR Rehabil Assist Technol 2025;12:e68268

Strategies and Tools for Electronic Health Records and Physician Workflow Alignment: Protocol for a Scoping Review

Strategies and Tools for Electronic Health Records and Physician Workflow Alignment: Protocol for a Scoping Review

In addition, it will incorporate the recent methodological development on scoping reviews, the PRISMA-Sc R (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) checklist into the main framework [28] (Multimedia Appendix 1). Consulting stakeholders is a vital aspect of the scoping review method. In this study, a librarian from the Weldon Library at the University of Western Ontario helped develop the search strategy.

Oluwakemi Olufunmilayo Oluwole, Nicole Haggerty, Uche Ikenyei, Oluwabambi Tinuoye, Andreawan Honora, Mohammed Abass Issakah

JMIR Res Protoc 2025;14:e60464

Aligning With the Goals of the Planetary Health Concept Regarding Ecological Sustainability and Digital Health: Scoping Review

Aligning With the Goals of the Planetary Health Concept Regarding Ecological Sustainability and Digital Health: Scoping Review

This scoping review followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 checklist [39,40] (Multimedia Appendix 1) without being registered under a protocol. This review investigated the impact of digitalization in health care on achieving environmental sustainability goals within the Planetary Health framework. The key research questions (RQs) were as follows: RQ1: What are the environmental benefits of health care digitalization?

Mathea Berger, Jan Peter Ehlers, Julia Nitsche

J Med Internet Res 2025;27:e71795

The Value of Remote Vital Signs Monitoring in Detecting Clinical Deterioration in Patients in Hospital at Home Programs or Postacute Medical Patients in the Community: Systematic Review

The Value of Remote Vital Signs Monitoring in Detecting Clinical Deterioration in Patients in Hospital at Home Programs or Postacute Medical Patients in the Community: Systematic Review

This systematic review was conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) methodology, which can be found in the Multimedia Appendix 1. It was registered in PROSPERO (International Prospective Register of Systematic Reviews; CRD42023388827) on January 17, 2023 [13]. A literature search was performed on January 16, 2023, using a search strategy approved by all authors in the following databases: Pub Med (MEDLINE), Embase, and Scopus.

Su-Ann Cheng, Shijie Ian Tan, Samuel Li Earn Goh, Stephanie Q Ko

J Med Internet Res 2025;27:e64753