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Assuming no additional improvement owing to a longer intervention, a sample size of 100 participants per group provides 80% power to detect a difference of 3.3 points between the intervention groups on the RBANS total index score (Cohen d=0.33) with an α of .05 and accounting for up to 20% attrition.
Using the results of previous web-based intervention studies designed to reduce AD risk in an RCT design [11,56], a 2-point difference in the ANU-ADRI total score between the groups is expected over time [41].
JMIR Res Protoc 2022;11(2):e31841
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