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Intervention for a Digital, Cognitive, Multi-Domain Alzheimer Risk Velocity Study: Protocol for a Randomized Controlled Trial

Intervention for a Digital, Cognitive, Multi-Domain Alzheimer Risk Velocity Study: Protocol for a Randomized Controlled Trial

Assuming no additional improvement owing to a longer intervention, a sample size of 100 participants per group provides 80% power to detect a difference of 3.3 points between the intervention groups on the RBANS total index score (Cohen d=0.33) with an α of .05 and accounting for up to 20% attrition. Using the results of previous web-based intervention studies designed to reduce AD risk in an RCT design [11,56], a 2-point difference in the ANU-ADRI total score between the groups is expected over time [41].

Michelle Gray, Erica N Madero, Joshua L Gills, Sally Paulson, Megan D Jones, Anthony Campitelli, Jennifer Myers, Nicholas T Bott, Jordan M Glenn

JMIR Res Protoc 2022;11(2):e31841