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Nationwide Implementation of Unguided Cognitive Behavioral Therapy for Adolescent Depression: Observational Study of SPARX

Nationwide Implementation of Unguided Cognitive Behavioral Therapy for Adolescent Depression: Observational Study of SPARX

Evidence-based talking therapies, including cognitive behavioral therapy (CBT), are the recommended first line of treatment for mild to moderate depression [4]. However, 50%‐80% of young people with symptoms do not get treatment [5]. Internet-based cognitive behavioral therapy (i CBT) programs have been developed, partly in response to these challenges, and have been shown to be effective for the treatment of adult and adolescent depression [6].

Terry Fleming, Mathijs Lucassen, Chris Frampton, Varsha Parag, Chris Bullen, Sally Merry, Matthew Shepherd, Karolina Stasiak

J Med Internet Res 2025;27:e66047


Mindful Nonreactivity, Anxiety, Depression, and Perceived Stress as Mediators of the Mindfulness Virtual Community Intervention—Pathways to Enhance Mental Health in University Students: Secondary Evaluation of Two Randomized Controlled Trials With Student Participants

Mindful Nonreactivity, Anxiety, Depression, and Perceived Stress as Mediators of the Mindfulness Virtual Community Intervention—Pathways to Enhance Mental Health in University Students: Secondary Evaluation of Two Randomized Controlled Trials With Student Participants

The MVC intervention was an 8-week web-based intervention based on mindfulness and cognitive-behavior therapy (M-CBT) principles that addressed psychological distress in university students [45,46]. This intervention comprised (1) a total of 16 psycho-educational and mindfulness meditation instruction videos (with associated printed text), (2) an anonymous peer discussion forum, and (3) an anonymous counselor-moderated video discussion session.

Meysam Pirbaglou, Christo El Morr, Farah Ahmad, Paul Ritvo

JMIR Ment Health 2025;12:e65853


Comparative Efficacy of Virtual Reality–Assisted Cognitive Behavioral Therapy Versus Yoga-Based Interventions for Reducing Performance Anxiety in Students: Protocol for a Randomized Controlled Trial

Comparative Efficacy of Virtual Reality–Assisted Cognitive Behavioral Therapy Versus Yoga-Based Interventions for Reducing Performance Anxiety in Students: Protocol for a Randomized Controlled Trial

O’Shea et al [24] noted that CBT is the standard psychological treatment for anxiety disorders. However, some individuals either do not access the treatment or do not benefit significantly from CBT alone. Finally, yoga, as a holistic mind-body practice, is seen as a potential CBT complement, providing benefits such as reduction in stress, anxiety, and depression through mindfulness, breathing, and movement techniques.

Cristina Maria Tofan, Liviu-Adrian Măgurianu, Magdalena Axinte, Alexandra Maria Găină, Marcel Găină

JMIR Res Protoc 2025;14:e66112


An App-Based Cognitive Behavioral Therapy Program Tailored for College Students: Randomized Controlled Trial

An App-Based Cognitive Behavioral Therapy Program Tailored for College Students: Randomized Controlled Trial

Cognitive behavioral therapy (CBT) is an evidence-based treatment with substantial evidence supporting its effectiveness in alleviating depressive symptoms [1]. However, delivery constraints, such as requiring 12‐16 weeks of face-to-face treatment by a professional, have hindered its widespread dissemination [2]. Recent advances in digital technology, including smartphones, have led to the development of technology-based CBT (t-CBT) programs that use digital tools.

Min Hee Kim, Yeon-kug Moon, Kyong-Mee Chung

JMIR Mhealth Uhealth 2025;13:e50006


The Role of Early Engagement in a Self-Directed, Digital Mental Health Intervention for Adolescent Anxiety: Moderated Regression Analysis

The Role of Early Engagement in a Self-Directed, Digital Mental Health Intervention for Adolescent Anxiety: Moderated Regression Analysis

For example, in a study on the d MH program, youth COACH, which targets chronic medical conditions in youth aged 12 and 21 years using cognitive behavioral therapy (CBT), only 40% of adolescents adhered to the intervention (completed at least 80% of the seven modules) [7].

Emma-Leigh Senyard, Arlen Rowe, Govind Krishnamoorthy, Susan H Spence, Caroline Donovan, Sonja March

JMIR Pediatr Parent 2025;8:e60523


Impact of Conversational and Animation Features of a Mental Health App Virtual Agent on Depressive Symptoms and User Experience Among College Students: Randomized Controlled Trial

Impact of Conversational and Animation Features of a Mental Health App Virtual Agent on Depressive Symptoms and User Experience Among College Students: Randomized Controlled Trial

Cognitive behavioral therapy (CBT)-based mental health apps represent a viable option to improve access to mental health resources [3]. A form of CBT, brief cognitive behavioral therapy (b CBT) has been suggested for depressive individuals as a means of maintaining the user’s attention while not requiring large amounts of the user’s time or energy.

Stephanie Six, Elizabeth Schlesener, Victoria Hill, Sabarish V Babu, Kaileigh Byrne

JMIR Ment Health 2025;12:e67381


Adapting Cognitive Behavioral Therapy for Adolescents in Iraq via Mobile Apps: Qualitative Study of Usability and Outcomes

Adapting Cognitive Behavioral Therapy for Adolescents in Iraq via Mobile Apps: Qualitative Study of Usability and Outcomes

Among the various therapeutic approaches, cognitive behavioral therapy (CBT) has proven to be particularly effective in addressing common adolescent mental health issues like anxiety and depression [20-24]. CBT focuses on helping individuals identify and modify negative thought patterns and behaviors, making it well suited for delivery via mobile platforms that offer interactive and self-guided modules [25-28].

Radhwan Hussein Ibrahim, Marghoob Hussein Yaas, Mariwan Qadir Hamarash, Salwa Hazim Al-Mukhtar, Mohammed Faris Abdulghani, Osama Al Mushhadany

JMIR Pediatr Parent 2025;8:e67137


Psychological eHealth Interventions for Patients With Cardiovascular Diseases: Systematic Review and Meta-Analysis

Psychological eHealth Interventions for Patients With Cardiovascular Diseases: Systematic Review and Meta-Analysis

For ICBT interventions, most incorporated core CBT techniques like behavioral activation, worry management, and problem-solving. Specific areas such as psychoeducation [33,35] or the psychosocial aspects of implantable cardioverter defibrillators [38] were the focus of some interventions. Additionally, certain programs integrated additional therapeutic methods, including interpersonal therapy [37] or mindfulness [24].

Jing Jing Su, Rose Lin, Ladislav Batalik, Arkers Kwan Ching Wong, Sherry L Grace

J Med Internet Res 2025;27:e57368


Personalized Physician-Assisted Sleep Advice for Shift Workers: Algorithm Development and Validation Study

Personalized Physician-Assisted Sleep Advice for Shift Workers: Algorithm Development and Validation Study

CBT-i Coach is another phone app developed as a supplemental tool for face-to-face CBTI in which users can receive sleep education, customize sleep hygiene advice and relaxation activities, and practice personalized sleep restrictions [27]. In a pilot study, the app did not impair CBTI effectiveness and potentially improved patient adherence [28].

Yufei Shen, Alicia Choto Olivier, Han Yu, Asami Ito-Masui, Ryota Sakamoto, Motomu Shimaoka, Akane Sano

JMIR Form Res 2025;9:e65000


Development of a Voice-Activated Virtual Assistant to Improve Insomnia Among Young Adult Cancer Survivors: Mixed Methods Feasibility and Acceptability Study

Development of a Voice-Activated Virtual Assistant to Improve Insomnia Among Young Adult Cancer Survivors: Mixed Methods Feasibility and Acceptability Study

Cognitive behavioral therapy for insomnia (CBT-I) is the gold standard intervention recommended by the National Comprehensive Cancer Network (NCCN) to address insomnia in cancer survivor populations [18-20]. Previous studies have demonstrated the effectiveness of CBT-I among YACSs [21,22]. However, widespread accessibility to CBT-I remains challenging due to an insufficient number of trained providers, a lack of insurance coverage, and even language barriers [23,24].

Hunter Groninger, Hannah Arem, Lylian Ayangma, Lisa Gong, Eric Zhou, Daniel Greenberg

JMIR Form Res 2025;9:e64869