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Effect of Semaglutide on Physical Function, Body Composition, and Biomarkers of Aging in Older Adults With Overweight and Insulin Resistance: Protocol for an Open-Labeled Randomized Controlled Trial

Although there is no standard set of biomarkers to obtain for evaluation of aging, systemic interleukin (IL)-6, tumor necrosis factors α (TNFα), C-reactive protein (CRP), and GDF15 are proposed biomarkers that are used in geroscience guided clinical trials [21]. A process that contributes to aging is cellular senescence, which is a stable cell cycle arrest triggered in normal cells that can lead to impaired tissue regeneration and chronic age-associated disease [22].

Tiffany M Cortes, Libia Vasquez, Monica C Serra, Ronna Robbins, Allison Stepanenko, Kevin Brown, Hannah Barrus, Annalisa Campos, Sara E Espinoza, Nicolas Musi

JMIR Res Protoc 2024;13:e62667

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The Influence of Branched-Chain Amino Acid Supplementation on Fatigue and Tryptophan Metabolism After Acute and Chronic Exercise in Older Adults: Protocol for a Pilot Randomized Controlled Trial

Plasma will be processed for the quantitative assessment of branched-chain amino acids and kynurenine metabolites using liquid chromatography–mass spectrometry, whereas plasma C-reactive protein, interleukin-6, interleukin-1β, and tumor necrosis factor-α will be measured by enzyme-linked immunosorbent assay (ELISA).

Ronna N Robbins, Tiffany Cortes, Jason C O'Connor, Rozmin Jiwani, Monica C Serra

JMIR Res Protoc 2023;12:e52199

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