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Racial Disparities in Parkinson Disease Clinical Phenotype, Management, and Genetics: Protocol for a Prospective Observational Study

Study participants will have a single visit with the site investigator and coordinator after obtaining consent or a hybrid combination of in-person and virtual visits. Recommendations of the NINDS PD CDE Working Group informed the choice of measures, scales, and questionnaires. Data will be collected and entered into a REDCap (Research Electronic Data Capture) system that uses electronic data entry forms.

Deborah A Hall, Josh M Shulman, Andrew Singleton, Sara Bandres Ciga, Michelle Hyczy S Tosin, Bichun Ouyang, Lisa Shulman

JMIR Res Protoc 2025;14:e60587

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Peer Mentoring Program for Informal Caregivers of Homebound Individuals With Advanced Parkinson Disease (Share the Care): Protocol for a Single-Center, Crossover Pilot Study

Briefly, IN-HOME-PD patient and caregiver dyads received 4 home protocol-driven home visits from a nurse and a social worker, each enhanced by a real-time telehealth connection with a movement disorders specialist over the course of approximately one year. The study described herein occurred between the second and third home visits for each dyad as illustrated in Figure 1. Study design.

Jori E Fleisher, Faizan Akram, Jeanette Lee, Ellen C Klostermann, Serena P Hess, Erica Myrick, Melissa Levin, Bichun Ouyang, Jayne Wilkinson, Deborah A Hall, Joshua Chodosh

JMIR Res Protoc 2022;11(5):e34750

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Longitudinal, Interdisciplinary Home Visits Versus Usual Care for Homebound People With Advanced Parkinson Disease: Protocol for a Controlled Trial

Parkinson disease (PD) is the second most common neurodegenerative condition; however, a substantial proportion of patients with advanced PD are disconnected from clinicians and researchers [1,2]. Many individuals with PD become homebound because of the progressive motor and functional disabilities that their disease imposes. Other comorbidities, limitations, absence of a caregiver, distance from care, or a combination thereof also contribute to a growing number of homebound individuals with PD.

Jori E Fleisher, Serena Hess, Brianna J Sennott, Erica Myrick, Ellen Klostermann Wallace, Jeanette Lee, Maya Sanghvi, Katheryn Woo, Bichun Ouyang, Jayne R Wilkinson, James Beck, Tricia J Johnson, Deborah A Hall, Joshua Chodosh

JMIR Res Protoc 2021;10(9):e31690

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Redesigning a Web-Based Stakeholder Consensus Meeting About Core Outcomes for Clinical Trials: Formative Feedback Study

To address the inconsistency of outcome selection, clinical trialists recommend developing a core outcome set (COS). A COS prescribes the minimum set of outcomes that should be measured and reported when testing an intervention for a given health condition. The Core Outcome Measures in Effectiveness Trials (COMET) initiative has published a handbook to promote good practice in COS development methods [2].

Roulla Katiri, Deborah A Hall, Derek J Hoare, Kathryn Fackrell, Adele Horobin, Nóra Buggy, Nicholas Hogan, Pádraig T Kitterick, Core Rehabilitation Outcome Set For Single-Sided Deafness (CROSSSD) Initiative

JMIR Form Res 2021;5(8):e28878

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Noninvasive Bimodal Neuromodulation for the Treatment of Tinnitus: Protocol for a Second Large-Scale Double-Blind Randomized Clinical Trial to Optimize Stimulation Parameters

The ascending auditory pathway has a well-organized spatial map of frequencies (ie, neurons located in a certain region respond best to a specific sound frequency, and this spatial ordering of frequencies is known as tonotopy or a tonotopic map).

Brendan Conlon, Caroline Hamilton, Stephen Hughes, Emma Meade, Deborah A Hall, Sven Vanneste, Berthold Langguth, Hubert H Lim

JMIR Res Protoc 2019;8(9):e13176

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Association Between Residual Inhibition and Neural Activity in Patients with Tinnitus: Protocol for a Controlled Within- and Between-Subject Comparison Study

To minimize variance across subjects, a within-subject measurement comparing the brain activity during a baseline period (tinnitus with abnormal brain activity) with a period after the suppression of tinnitus (stabilization of abnormal activity) may overcome this limitation. Residual inhibition (RI) is a temporary forward tinnitus suppression mechanism, which can reduce or alleviate tinnitus loudness for a short duration after the presentation of an acoustic stimulus [45,46].

Suyi Hu, Lukas Anschuetz, Markus E Huth, Raphael Sznitman, Daniela Blaser, Martin Kompis, Deborah A Hall, Marco Caversaccio, Wilhelm Wimmer

JMIR Res Protoc 2019;8(1):e12270

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The Physiological Bases of Hidden Noise-Induced Hearing Loss: Protocol for a Functional Neuroimaging Study

A striking discovery showed that noise exposure can cause substantial neural damage without a reduction in threshold sensitivity. Mice exposed to a 100 decibel sound pressure level (d B SPL) stimulus for just 2 hours permanently lost up to half of their hair-cell or auditory-nerve synapses in certain frequency regions (cochlear synaptopathy), despite a complete recovery of thresholds for sounds in quiet [7].

Rebecca Susan Susan Dewey, Deborah A Hall, Hannah Guest, Garreth Prendergast, Christopher J Plack, Susan T Francis

JMIR Res Protoc 2018;7(3):e79

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