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Impact of Mānuka Honey on Symptoms and Quality of Life in Individuals With Functional Dyspepsia: Protocol for a Feasibility Randomized Controlled Trial

Impact of Mānuka Honey on Symptoms and Quality of Life in Individuals With Functional Dyspepsia: Protocol for a Feasibility Randomized Controlled Trial

During the intervention phase, participants in 2 arms consumed 10 g of mānuka honey, standardized to contain either 10 mg or 40 mg/kg of Lepteridine twice daily. The third arm received 10 g of honey maple–flavored syrup twice daily as a placebo control. Study flowchart. BID: bis in die (10 g of allocated intervention twice daily, before breakfast and dinner).

Laura Ombasa, Jody Miller, Lara Ware, Holly Abbotts-Holmes, Jeffry Tang, Olivier Gasser, Karl Fraser, Simone Bayer, Roslyn Kemp, Rory Costello, Andrew Highton, Jackie Evans, Troy Merry, Michael Schultz, Chris Frampton, Richard Gearry, Warren McNabb, Nicole Roy

JMIR Res Protoc 2025;14:e66417

Short- and Long-Term Effectiveness of Brief Intensive Trauma Treatment for Adolescents With Posttraumatic Stress Disorder and Their Caregivers: Protocol for a Multicenter Randomized Controlled Trial

Short- and Long-Term Effectiveness of Brief Intensive Trauma Treatment for Adolescents With Posttraumatic Stress Disorder and Their Caregivers: Protocol for a Multicenter Randomized Controlled Trial

must meet all of the following criteria: 12-18 years of age; A history of psychological trauma (as measured by the Life Events Checklist of the Clinician-Administered Posttraumatic Stress Disorder Scale for Children and Adolescents in the DSM-5 [Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition)]) [35,36]; At least subthreshold posttraumatic stress disorder criteria, conform to the Clinician-Administered PTSD Scale for Children and Adolescents DSM-5, that is: fully meets criteria A, F, and G,

Myrna M Westerveld, Malindi van der Mheen, Rik Knipschild, Kim Maijer, Marieke E de Keizer-Altink, Nina Albisser, Marielle J E Hoekstra, Anne Timmermans-Jansen, Rosa Zijp, Anne A Krabbendam, Francisca J A (Bonny) van Steensel, Kees-Jan Kan, Chaim Huyser, Wouter G Staal, Elisabeth M W J Utens, Ramón J L Lindauer

JMIR Res Protoc 2025;14:e66115