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Acute Adenosine Receptor Antagonism in Combination With Acute Intermittent Hypoxia to Promote Breathing Plasticity in Amyotrophic Lateral Sclerosis: Protocol for a Randomized, Double-Blinded, Placebo-Controlled Trial

Acute Adenosine Receptor Antagonism in Combination With Acute Intermittent Hypoxia to Promote Breathing Plasticity in Amyotrophic Lateral Sclerosis: Protocol for a Randomized, Double-Blinded, Placebo-Controlled Trial

Respiratory data will be recorded during gas delivery, using a data acquisition system (Power Lab 16/35 and Power Lab C; ADInstruments). Respiratory rate, targeted O2 value, end-tidal CO2, HR/rhythm, and Sp O2 will be continuously monitored during the testing sessions.

Priscila Sales de Campos, May Smith-Hublou, Wendy L Olsen, Wagner Souza Leite, James P Wymer, Nicholas J Napoli, Alicia K Vose, Michael T Pulley, Gordon S Mitchell, Barbara K Smith

JMIR Res Protoc 2025;14:e76105