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Temporal Dynamics of Subtle Cognitive Change: Validation of a User-Friendly Multidomain Digital Assessment Using an Alcohol Challenge

Temporal Dynamics of Subtle Cognitive Change: Validation of a User-Friendly Multidomain Digital Assessment Using an Alcohol Challenge

Respondents are asked to place a mark on the line representing their current feeling of intoxication, and its position is later measured using a ruler to extract a value. The experiment follows a repeated-measures, placebo-controlled (single-blind) crossover within-participant design (see Figure 3). The order of treatment was counterbalanced, such that half of the participants (n=15) received alcohol in their first session and a placebo in their second.

John Frederick Dyer, Florentine Marie Barbey, Ayan Ghoshal, Ann Marie Hake, Bryan J Hansen, Md Nurul Islam, Judith Jaeger, Rouba Kozak, Hugh Marston, Mark Moss, Viet Nguyen, Rebecca Louise Quinn, Leslie A Shinobu, Elizabeth Tunbridge, Brian Murphy, Niamh Kennedy

J Med Internet Res 2025;27:e55469

Implications of Data Extraction and Processing of Electronic Health Records for Epidemiological Research: Observational Study

Implications of Data Extraction and Processing of Electronic Health Records for Epidemiological Research: Observational Study

According to this legislation, neither obtaining informed consent from patients nor approval by a medical ethics committee is obligatory for these types of observational studies that contain no directly identifiable patient data (art. 24 GDPR Implementation Act jo art. 9.2 sub j GDPR). For Nivel-PCD, the project has been approved by the relevant governance bodies of Nivel-PCD under number NZR-00320.087. As mentioned, the EHR data used in this study were pseudonymized before analysis.

Melissa H J van Essen, Robin Twickler, Yvette M Weesie, Ilgin G Arslan, Feikje Groenhof, Lilian L Peters, Isabelle Bos, Robert A Verheij

J Med Internet Res 2025;27:e64628