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Temporal Dynamics of Subtle Cognitive Change: Validation of a User-Friendly Multidomain Digital Assessment Using an Alcohol Challenge

Temporal Dynamics of Subtle Cognitive Change: Validation of a User-Friendly Multidomain Digital Assessment Using an Alcohol Challenge

Respondents are asked to place a mark on the line representing their current feeling of intoxication, and its position is later measured using a ruler to extract a value. The experiment follows a repeated-measures, placebo-controlled (single-blind) crossover within-participant design (see Figure 3). The order of treatment was counterbalanced, such that half of the participants (n=15) received alcohol in their first session and a placebo in their second.

John Frederick Dyer, Florentine Marie Barbey, Ayan Ghoshal, Ann Marie Hake, Bryan J Hansen, Md Nurul Islam, Judith Jaeger, Rouba Kozak, Hugh Marston, Mark Moss, Viet Nguyen, Rebecca Louise Quinn, Leslie A Shinobu, Elizabeth Tunbridge, Brian Murphy, Niamh Kennedy

J Med Internet Res 2025;27:e55469