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Generative AI as Third Agent: Large Language Models and the Transformation of the Clinician-Patient Relationship

Generative AI as Third Agent: Large Language Models and the Transformation of the Clinician-Patient Relationship

The rise of internet use for health information and self-diagnosis fueled a movement of e-patients [5] even as medical professionals raised concerns regarding the impact of “Dr. Google” on patient-clinician relations. The ship is sailed: as many as half of Americans seek health care information online for themselves or others, without evidence of negative effects on health outcomes or the patient-clinician relationship [3,6,7].

Hugo de O Campos, Daniel Wolfe, Hongzhou Luan, Ida Sim

J Particip Med 2025;17:e68146

The Cost-Effectiveness of Digitally Supported Mental Well-Being Prevention and Promotion Targeting Nonclinical Adult Populations: Systematic Review

The Cost-Effectiveness of Digitally Supported Mental Well-Being Prevention and Promotion Targeting Nonclinical Adult Populations: Systematic Review

This finding could be related to a lack of integration of the e-mental health tools in the workplace, resulting in reduced effectiveness [64]. Indicated prevention using digitally supported tools appeared to be cost-effective [54], dominant (ie, better health outcomes at lower costs) [55,56,59,63], or cost-saving [60] (Figure 3).

Sara Claes, Fleur Van De Wielle, Els Clays, Lieven Annemans

JMIR Ment Health 2025;12:e72458

Adoption of Personal Health Records in Dutch Hospitals and Private Medical Clinics: Longitudinal Study

Adoption of Personal Health Records in Dutch Hospitals and Private Medical Clinics: Longitudinal Study

Perotti et al [39] evaluated an e-learning to promote PHR competence and found how e-learning enhanced knowledge of PHRs, skill acquisition to use PHRs, and improved task completion. PHR providers are encouraged to develop and provide a publicly accessible e-learning for PHR users [39].

Doris van der Smissen, Christine Leenen-Brinkhuis, Kim M E Janssens, Petra J Porte, Marcel A L M van Assen, Anne Marie Weggelaar-Jansen

J Med Internet Res 2025;27:e71915

Patient Perspectives on Open-Door Policies in Psychiatry: Mixed Methods Study

Patient Perspectives on Open-Door Policies in Psychiatry: Mixed Methods Study

The deliberate decision to forego locked doors fosters closer therapeutic relationships with severely ill patients and necessitates a high degree of creativity, vigilance, and professional commitment to de-escalate potentially volatile situations. Naturally, the successful application of such an approach is contingent upon adequate staffing levels and appropriate personnel resources [50].

Timur Liwinski, Robert Davidson, Jan Sarlon, Rainer Gaupp, Lukas Imfeld, Annette B Brühl, Marc Vogel, Christian G Huber, Undine E Lang

J Med Internet Res 2025;27:e73610

Guidelines for Rapport-Building in Telehealth Videoconferencing: Interprofessional e-Delphi Study

Guidelines for Rapport-Building in Telehealth Videoconferencing: Interprofessional e-Delphi Study

Building upon previous descriptive studies [9,10,13,20,28-31], this project aimed to use an e-Delphi study to explore what relationship-based care elements are important to include in a telehealth curriculum. This will provide a strong foundation for the future curricula development of interprofessional students and clinicians across disciplines while closing a crucial gap in our practice and pedagogical knowledge.

Paula D Koppel, Jennie C De Gagne, Michelle Webb, Denise M Nepveux, Janelle Bludorn, Aviva Emmons, Paige S Randall, Neil S Prose

JMIR Med Educ 2025;11:e76260

Novel Virtual Reality Intervention for Stress Reduction Among Patients With or at Risk for Cardiovascular Disease: Mixed Methods Pilot Study

Novel Virtual Reality Intervention for Stress Reduction Among Patients With or at Risk for Cardiovascular Disease: Mixed Methods Pilot Study

Participants were emailed a US $25 Amazon e-gift code. Study procedure flowchart. GSR: galvanic skin response; HR: heart rate; HRV: heart rate variability. The study was approved by the UCLA Institutional Review Board (#21‐000705), and the Clinical Trials.gov registry number was NCT0498465. Written informed consent was obtained. The privacy and confidentiality of research participants’ data and identity were maintained. Participants were compensated with US $25 Amazon gift cards.

Katherine E Makaroff, Christopher Van, Vincent Grospe, Lynae Edmunds, Marcella A Calfon-Press, Karol E Watson, Tamara Horwich

JMIR Cardio 2025;9:e66557

Variability in the Diagnosis and Treatment of Interstitial Cystitis/Bladder Pain Syndrome: Internet Survey

Variability in the Diagnosis and Treatment of Interstitial Cystitis/Bladder Pain Syndrome: Internet Survey

The participants received a US $25 e-gift card as compensation for completing the full survey. To prevent fraud, provided emails were compared to those on the mailing and membership lists, and data from unknown individuals were not included. In the case of duplicates, only the first completed survey was included in the analysis. Deidentified survey responses, with all personally identifiable information removed, are available for secondary data analysis.

Eleanora Melkonian, A Leigh Garrett, Erika Kline, Pressley Smith, Madelyn Wiesenhahn, Jeanette Petit, Alison Swierczynski, Carley Zhou, Stuart B Bauer, Rosalyn Adam, Kamil E Barbour, Sonja I Ziniel, Catherine A Brownstein

JMIR Form Res 2025;9:e70813