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Digital Conversational Agents for the Mental Health of Treatment-Seeking Youth: Scoping Review

A randomized controlled trial (RCT) of a digital conversational agent called Woebot found that, compared to a self-help e-book, the intervention significantly reduced depressive symptoms after 2 weeks, with a moderate effect size (d=0.44) [2]. In another RCT, 4 weeks of using Woebot was found to be noninferior to a standard clinician-led CBT group in reducing depression when comparing pre-post average scores and the number of participants with elevated depression; the effect size was not provided [30].

Lisa D Hawke, Jingyi Hou, Anh T P Nguyen, Thalia Phi, Jamie Gibson, Brian Ritchie, Gillian Strudwick, Terri Rodak, Louise Gallagher

JMIR Ment Health 2025;12:e77098

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Healthy Body and Mind Program to Improve Health Outcomes and Reduce Dementia Risk in People With Osteoarthritis: Protocol for a Feasibility and Acceptability Pilot Randomized Controlled Trial

Claire V Burley, William Yeates, Kelly A McLeod, Matthew D Jones, Nattai Borges, Henry Brodaty, Belinda J Parmenter

JMIR Res Protoc 2025;14:e75816

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Personalization Strategies for Increasing Engagement With Digital Mental Health Resources: Sequential Multiple Assignment Randomized Trial

Participants who completed the demographics survey could be randomized to the TR-D condition, which showed participants a nontailored message (ie, brief description of PHQ-9 results) and featured resources tailored to age and LGBTQ+ status. A pool of 3 to 4 possible resources for each age group was chosen by an algorithm that identified the most popular resources within each age group.

Julien Rouvere, Isabell R Griffith Fillipo, Meghan Romanelli, Ashish Sharma, Brittany A Mosser, Theresa Nguyen, Kevin Rushton, John Marion, Tim Althoff, Michael D Pullmann

JMIR Ment Health 2025;12:e73188

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Acceptability of a Conversational Agent–Led Digital Program for Anxiety: Mixed Methods Study of User Perspectives

Pearla Papiernik, Sylwia Dzula, Marta Zimanyi, Edward Millgate, Malika Bouazzaoui, Jessica Buttimer, Graham Warren, Elisa Cooper, Ana Catarino, Shaun Mehew, Emily Marshall, Valentin Tablan, Andrew D Blackwell, Clare E Palmer

JMIR Hum Factors 2025;12:e76377

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Group Cognitive Behavioral Therapy With Virtual Reality Exposure Versus In-Vivo Exposure for Social Anxiety Disorder and Agoraphobia: Underpowered Results From the SoREAL Pragmatic Randomized Clinical Trial

These thresholds reflect the smallest clinically meaningful change, corresponding to a Cohen d of 0.33 based on prior studies' standard deviations [59,60]. Treatment fidelity was evaluated using a therapist self-report questionnaire administered 5 times throughout therapy, consisting of 6 Likert-style questions (ranging from 1 to 5) and questions about time spent on exposure therapy.

Benjamin Arnfred, Fatime Zeka, Carsten Hjorthøj, Clas Winding Christensen, Kirsten Stengaard Moeller, Mette Øllgaard Pedersen, Nicole Rosenberg, Lars Clemmensen, Louise Birkedal Glenthøj, Merete Nordentoft