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Predictive Models Using Machine Learning to Identify Fetal Growth Restriction in Patients With Preeclampsia: Development and Evaluation Study

Predictive Models Using Machine Learning to Identify Fetal Growth Restriction in Patients With Preeclampsia: Development and Evaluation Study

They have an increased risk of perinatal or long-term complications, such as fetal asphyxia, neurodevelopmental disabilities, cardiovascular disease, and type 2 diabetes, compared with normally grown fetuses [6,7]. It is often accompanied by preeclampsia, which may result in increased perinatal mortality. Thus the early identification and intervention of FGR are crucial for improving its perinatal outcomes.

Qing Hua, Fengchun Yang, Yadan Zhou, Fenglian Shi, Xiaoyan You, Jing Guo, Li Li

J Med Internet Res 2025;27:e70068

Evaluation of Diagnostic Recommendations Embedded in Medication Alerts: Prospective Single-Arm Interventional Study

Evaluation of Diagnostic Recommendations Embedded in Medication Alerts: Prospective Single-Arm Interventional Study

Second, while the year-long study minimized temporal bias, variations in physician behavior across shifts, differing workloads, or individual factors such as system familiarity and clinical preferences were not specifically analyzed. Additionally, the gradual adoption of Med Guard across participating physicians may have introduced selection bias, as early adopters may differ in prescribing behavior or familiarity with clinical decision support systems compared with those who joined later.

Yu-Chen Liu, Guan-Ling Lin, Jeremiah Scholl, Yi-Chun Hung, Yu-Jing Lin, Yu-Chuan Li, Hsuan-Chia Yang

J Med Internet Res 2025;27:e70731

Factors Influencing the Severity of Urinary and Defecatory Dysfunction Among the Middle-Aged and Older Adult Chinese Population: Longitudinal Study of a 5-Wave Survey Cohort

Factors Influencing the Severity of Urinary and Defecatory Dysfunction Among the Middle-Aged and Older Adult Chinese Population: Longitudinal Study of a 5-Wave Survey Cohort

This common disorder can have a negative impact on the quality of life of patients and exacerbate their economic burden, particularly in long-term or severe cases [13-16]. Numerous studies have demonstrated that UDD may be associated with chronic conditions (such as hypertension, diabetes, stroke, depression, and so on), abnormal BMI (overweight, obesity, or underweight), handgrip strength, and unhealthy lifestyle factors such as smoking and drinking [10,17-22].

Haoran Zhu, Xiaoming Li, Liwei Jing, Jingli Kou, Lichao Gong, Rui Wang, Guangtian Liu, Chao Zhang, Jiayi Zhao, Jing Zhang

JMIR Aging 2025;8:e70541

Supervised Machine Learning Models for Predicting Sepsis-Associated Liver Injury in Patients With Sepsis: Development and Validation Study Based on a Multicenter Cohort Study

Supervised Machine Learning Models for Predicting Sepsis-Associated Liver Injury in Patients With Sepsis: Development and Validation Study Based on a Multicenter Cohort Study

Both the initial lactate level at admission and subsequent lactate clearance serve as important predictors of short- and long-term mortality in patients with cirrhosis [34,40]. The American Association for the Study of Liver Diseases [41] has highlighted that in patients with acute liver failure, an elevated lactate level (>4 mmol/L) is an independent risk factor for poor prognosis. In patients with chronic liver disease, lactate levels are strongly correlated with in-hospital mortality.

Jingchao Lei, Jia Zhai, Yao Zhang, Jing Qi, Chuanzheng Sun

J Med Internet Res 2025;27:e66733

Effectiveness of Neurofeedback-Assisted and Conventional 6-Week Web-Based Mindfulness Interventions on Mental Health of Chinese Nursing Students: Randomized Controlled Trial

Effectiveness of Neurofeedback-Assisted and Conventional 6-Week Web-Based Mindfulness Interventions on Mental Health of Chinese Nursing Students: Randomized Controlled Trial

Specifically, the sample size was calculated via the Hsu (with best) multiple comparison test by the Power Analysis and Sample Size 14, with α=.05, power=0.80, the MDs between different groups=6.139, and the common SD within a group was assumed to be 7.16, resulting in a total sample size of 138 (46 in each group). Accounting for a 10% dropout rate, the final sample size was planned to be 153 participants.

Shu Jing, Zhenwei Dai, Xiaoyang Liu, Xuelin Yang, Jinglei Cheng, Tianming Chen, Zihang Feng, Xin Liu, Fenghe Dong, You Xin, Zhuoyan Han, Haiyan Hu, Xiaoyou Su, Chen Wang

J Med Internet Res 2025;27:e71741

Effect of Gamification on Improved Adherence to Inhaled Medications in Chronic Obstructive Pulmonary Disease: Randomized Controlled Trial

Effect of Gamification on Improved Adherence to Inhaled Medications in Chronic Obstructive Pulmonary Disease: Randomized Controlled Trial

This raises concerns about whether patients are correctly inhaling their medication over the long term [14,15]. In addition, lengthy and monotonous educational materials may lack appeal for patients with COPD [16]. In clinical practice, medical professionals provide health education manuals [17] and videos demonstrating proper inhaler techniques [18], which result in passive patient education.

Xiting Huang, Zhili Jiang, Yifan Dai, Yang Liu, Ziying Dai, Jing Wang, Liping Chen, Zhiqian Wang, Wenxiao Wu, Lihua Huang

J Med Internet Res 2025;27:e65309

Combination of Electroacupuncture and Medication for Patients With Tinnitus Associated With Idiopathic Sudden Sensorineural Hearing Loss: Protocol for a Prospective Randomized Controlled Trial

Combination of Electroacupuncture and Medication for Patients With Tinnitus Associated With Idiopathic Sudden Sensorineural Hearing Loss: Protocol for a Prospective Randomized Controlled Trial

For limb acupoints, 30-gauge needles (0.25 mm in diameter, 40 mm long) will be inserted to a depth of 10-15 mm. For head acupoints, 32-gauge needles (0.25 mm in diameter, 25 mm long) will be inserted to a depth of 3 mm. A specialized acupuncture technique will be used when needling the Tinggong point (SI19) on the impacted side. The patient will be instructed to slightly open their mouth, and a needle (0.25 mm in diameter, 40 mm long) will be inserted to a depth of approximately 15-25 mm.

Tuoran Wang, Lingyu Qi, Xinping Hao, Miao Zhang, Shihao Du, Biao Chen, Chang Liu, Jing Chen, Xinyue Zou, Ping Liu, Jin Huo

JMIR Res Protoc 2025;14:e69163

Effects of Traditional Chinese Exercise Yijinjing on Disability and Muscle Strength Among Patients With Chronic Low Back Pain: Protocol for a Randomized Controlled Trial

Effects of Traditional Chinese Exercise Yijinjing on Disability and Muscle Strength Among Patients With Chronic Low Back Pain: Protocol for a Randomized Controlled Trial

In China, many patients with CLBP voluntarily seek Yijinjing, which has a long history as an ancient traditional Chinese exercise therapy that originated in 221 BC. It combines positive thinking with deep contemplation, fluid movement, deep breathing, and relaxation techniques to promote the circulation of vital energy (or Qi) throughout the body [14]. It is considered a multifaceted intervention that includes physical, mental, social, emotional, spiritual, and cognitive-behavioral aspects.

Lei Guo, Cheng Wang, Xue Bai, Yukui Tian, Mengni Shi, Min Fang, Jing Xian Li, Qingguang Zhu, Junchang Liu

JMIR Res Protoc 2025;14:e67557

Effectiveness of Serious Games as Digital Therapeutics for Enhancing the Abilities of Children With Attention-Deficit/Hyperactivity Disorder (ADHD): Systematic Literature Review

Effectiveness of Serious Games as Digital Therapeutics for Enhancing the Abilities of Children With Attention-Deficit/Hyperactivity Disorder (ADHD): Systematic Literature Review

Although ADHD medications exhibit significant therapeutic effects [5], some guardians are reluctant to medicate their children due to potential long-term adverse developmental effects and varying effectiveness across different ADHD subtypes [6,7]. Furthermore, the core symptoms of ADHD, which include inattention and hyperactivity-impulsivity, typically necessitate multiple therapeutic interventions to ensure effective management [8].

Jing Lin, Woo-Rin Chang

JMIR Serious Games 2025;13:e60937