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Evaluating the Accuracy of Web-Based and In-Clinic Subjective Cognitive Decline Assessments in Detecting Cognitive Impairment: Multicohort Study

Evaluating the Accuracy of Web-Based and In-Clinic Subjective Cognitive Decline Assessments in Detecting Cognitive Impairment: Multicohort Study

We produced descriptive statistics according to the diagnostic groups (CU and CI) and web-based or in-clinic study setting (BHR and ADNI) and compared demographic and clinical information and ECog scores between groups using independent t test (2-tailed) and chi-square test. To test the first hypothesis that the web-based ECog can distinguish diagnostic groups, we performed binomial logistic regression analyses with the diagnostic group (CU or CI) as the dependent variable.

Jae Myeong Kang, Manchumad Manjavong, Adam Diaz, Miriam T Ashford, Anna Aaronson, Joseph Eichenbaum, Scott Mackin, Rachana Tank, Melanie J Miller, Bernard Landavazo, Erika Cavallone, Diana Truran, Monica R Camacho, Juliet Fockler, Derek Flenniken, Sarah Tomaszewski Farias, Michael W Weiner, Rachel Nosheny

J Med Internet Res 2025;27:e69689

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Optimizing Cardiovascular Risk Management in Primary Care Using a Personalized eCoach Solution Enhanced by an Artificial Intelligence–Driven Clinical Prediction Model: Protocol from the Coronary Artery Disease Risk Estimation and Early Detection Consortium

Optimizing Cardiovascular Risk Management in Primary Care Using a Personalized eCoach Solution Enhanced by an Artificial Intelligence–Driven Clinical Prediction Model: Protocol from the Coronary Artery Disease Risk Estimation and Early Detection Consortium

A paired sample t test will be performed for at least the 10-year ASCVD risk, assuming normality. Individual components, including systolic blood pressure, use of blood pressure medication, total cholesterol, HDL, use of lipid-modifying agents, smoking status, and moderate to vigorous physical activity, will be evaluated using the Mc Nemar test for dichotomous outcomes and the paired sample t test for continuous variables.

Rutger van Mierlo, Bart Scheenstra, Joost Verbeek, Anke Bruninx, Petros Kalendralis, Inigo Bermejo, Andre Dekker, Arnoud van 't Hof, Marieke Spreeuwenberg, Laura Hochstenbach

JMIR Res Protoc 2025;14:e66068

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