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Sodium Oxybate as a Potential New Treatment for Catatonia in Patients With Depression, Bipolar Disorder, or a Psychotic Disorder: Protocol for a Randomized Controlled Trial

Sodium Oxybate as a Potential New Treatment for Catatonia in Patients With Depression, Bipolar Disorder, or a Psychotic Disorder: Protocol for a Randomized Controlled Trial

Sodium oxybate will be titrated up to 27 g/day (4.5 g every 4 h). If, after 4 days of treatment, patients improve more than 50% on the BFCRS, they may continue sodium oxybate treatment for an additional 10 days. If no response or remission has been achieved, patients will, in general, receive ECT. However, this decision lies outside the scope of this study and is a decision made between the treating professional, the patient, and his or her legal representative, in case of incapability.

Lilian Bot, Josine G van Mill, Laetitia J C A Smarius, Adriaan W Hoogendoorn, Bram W C Storosum, Christiaan H Vinkers, Gabriel E Jacobs, Gert Jan Lammers, Hanna M Heller, Jantine C A Colen-de Koning, Joris J B van der Vlugt, Marloes S Oudijn, Martijn S van Noorden, Pierre M Bet, Rolf Fronczek, Heleen S van der Heijden, Sjors M M Lange, Ysbrand D van der Werf, Eric R van Exel

JMIR Res Protoc 2025;14:e68356

A Human-Centered Approach for a Student Mental Health and Well-Being Mobile App: Protocol for Development, Implementation, and Evaluation

A Human-Centered Approach for a Student Mental Health and Well-Being Mobile App: Protocol for Development, Implementation, and Evaluation

ACTRI: Altman Clinical and Translational Research Institute; CAPS: Counseling and Psychological Services; H&W: Health and Wellness; R&D: Research and Development; UC: University of California; UCSD: University of California San Diego.

Maryam Gholami, David Wing, Manas Satish Bedmutha, Job Godino, Anahi Ibarra, Byron Fergerson, Nicole May, Christopher A Longhurst, Nadir Weibel, Anne Duffy, Heidi Rataj, Karandeep Singh, Kevin Patrick

JMIR Res Protoc 2025;14:e68368