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Sodium Oxybate as a Potential New Treatment for Catatonia in Patients With Depression, Bipolar Disorder, or a Psychotic Disorder: Protocol for a Randomized Controlled Trial

Sodium Oxybate as a Potential New Treatment for Catatonia in Patients With Depression, Bipolar Disorder, or a Psychotic Disorder: Protocol for a Randomized Controlled Trial

Sodium oxybate will be titrated up to 27 g/day (4.5 g every 4 h). If, after 4 days of treatment, patients improve more than 50% on the BFCRS, they may continue sodium oxybate treatment for an additional 10 days. If no response or remission has been achieved, patients will, in general, receive ECT. However, this decision lies outside the scope of this study and is a decision made between the treating professional, the patient, and his or her legal representative, in case of incapability.

Lilian Bot, Josine G van Mill, Laetitia J C A Smarius, Adriaan W Hoogendoorn, Bram W C Storosum, Christiaan H Vinkers, Gabriel E Jacobs, Gert Jan Lammers, Hanna M Heller, Jantine C A Colen-de Koning, Joris J B van der Vlugt, Marloes S Oudijn, Martijn S van Noorden, Pierre M Bet, Rolf Fronczek, Heleen S van der Heijden, Sjors M M Lange, Ysbrand D van der Werf, Eric R van Exel

JMIR Res Protoc 2025;14:e68356

A Resource-Efficient, High-Dose, Gamified Neurorehabilitation Program for Chronic Stroke at Home: Retrospective Real-World Analysis

A Resource-Efficient, High-Dose, Gamified Neurorehabilitation Program for Chronic Stroke at Home: Retrospective Real-World Analysis

The target dose was consistent with a previous large telerehabilitation study that showed significant improvements in upper-limb impairment (42 h [29]). In contrast, training in this program was not limited to one body area [30-32] and could be achieved with multiple effectors (ie, upper-limb, hand, trunk, and lower-limb). Training dose was delivered via synchronous telerehabilitation and asynchronous training (Table 2).

Spencer A Arbuckle, Anna Sophie Knill, Michelle H Chan-Cortés, Gabriela Rozanski, Anastasia Elena Ford, Louis T Derungs, John W Krakauer, Naveed Ejaz, David Putrino, Jenna Tosto-Mancuso, Meret Branscheidt

JMIR Serious Games 2025;13:e69335