Currently submitted to: JMIR Aging
Date Submitted: Jun 27, 2019
Open Peer Review Period: Jul 2, 2019 - Aug 27, 2019
(currently open for review)
Association between Cognitive Decline and Oral Health Status in the Aging Population – A 5- year prospective cohort study
Till date no longitudinal prospective study have investigated the association between the oral health status and cognitive decline in the geriatric Indian population, possibly due to past studies differing in target groups and methodologies. We aimed to investigate the association between tooth loss, as evaluated through clinical oral examinations, and the development of cognitive decline in the older adults while considering baseline cognitive function.
to investigate the association between tooth loss, as evaluated through clinical oral examinations, and the development of cognitive decline in the older adults while considering baseline cognitive function.
This 5-year prospective cohort study followed 140 participants (mean age: 72.5 ± 4.3 years) without cognitive impairment aged ≥65 years (mean age: 70.9 ± 4.3 years) living in the Dhule Region of Maharashtra , India. Cognitive function was evaluated with the Mini-Mental State Examination (MMSE) in baseline and follow-up surveys,while oral health examination was carried out using Oral Hygiene Index To investigate the association between oral health status and cognitive decline, we applied a multiple logistic regression analysis adjusted for age, gender, hypertension, diabetes, cerebrovascular/cardiovascular disease, hypercholesterolemia, depressive symptoms, body mass index, smoking status, drinking status, duration of education, and baseline MMSE score.
In the 5 years after the baseline survey, we have obtained an overall incidence of 20.71%. population who developed cognitive decline (i.e., MMSE scores of ≤24). Multivariable logistic regression analysis indicated that participants with compromised oral health were more likely to develop cognitive decline than those with mild to moderate oral health were (odds ratio: 3.31; 95% confidence interval: 1.07–10.2). Age, male gender, and baseline MMSE scores were also significantly associated with cognitive decline.
Poor Oral health status was independently associated with the development of cognitive decline within 5 years among the geriatric population of India . This finding corroborates the hypothesis that oral health may be a predictor or risk factor for cognitive decline. Clinical Trial: Not applied
Request queued. Please wait while the file is being generated. It may take some time.
© The authors. All rights reserved. This is a privileged document currently under peer-review/community review (or an accepted/rejected manuscript). Authors have provided JMIR Publications with an exclusive license to publish this preprint on it's website for review and ahead-of-print citation purposes only. While the final peer-reviewed paper may be licensed under a cc-by license on publication, at this stage authors and publisher expressively prohibit redistribution of this draft paper other than for review purposes.