TY - JOUR AU - Ye, Siao AU - Sun, Kevin AU - Huynh, Duong AU - Phi, Huy Q AU - Ko, Brian AU - Huang, Bin AU - Hosseini Ghomi, Reza PY - 2022 DA - 2022/4/15 TI - A Computerized Cognitive Test Battery for Detection of Dementia and Mild Cognitive Impairment: Instrument Validation Study JO - JMIR Aging SP - e36825 VL - 5 IS - 2 KW - cognitive test KW - mild cognitive impairment KW - dementia KW - cognitive decline KW - repeatable battery KW - discriminant analysis AB - Background: Early detection of dementia is critical for intervention and care planning but remains difficult. Computerized cognitive testing provides an accessible and promising solution to address these current challenges. Objective: The aim of this study was to evaluate a computerized cognitive testing battery (BrainCheck) for its diagnostic accuracy and ability to distinguish the severity of cognitive impairment. Methods: A total of 99 participants diagnosed with dementia, mild cognitive impairment (MCI), or normal cognition (NC) completed the BrainCheck battery. Statistical analyses compared participant performances on BrainCheck based on their diagnostic group. Results: BrainCheck battery performance showed significant differences between the NC, MCI, and dementia groups, achieving 88% or higher sensitivity and specificity (ie, true positive and true negative rates) for separating dementia from NC, and 77% or higher sensitivity and specificity in separating the MCI group from the NC and dementia groups. Three-group classification found true positive rates of 80% or higher for the NC and dementia groups and true positive rates of 64% or higher for the MCI group. Conclusions: BrainCheck was able to distinguish between diagnoses of dementia, MCI, and NC, providing a potentially reliable tool for early detection of cognitive impairment. SN - 2561-7605 UR - https://aging.jmir.org/2022/2/e36825 UR - https://doi.org/10.2196/36825 UR - http://www.ncbi.nlm.nih.gov/pubmed/35436212 DO - 10.2196/36825 ID - info:doi/10.2196/36825 ER -