TY  - JOUR
AU  - Groppell, Samantha
AU  - Soto-Ruiz, Karina M
AU  - Flores, Benjamin
AU  - Dawkins, William
AU  - Smith, Isabella
AU  - Eagleman, David M
AU  - Katz, Yael
PY  - 2019
DA  - 2019/03/21
TI  - A Rapid, Mobile Neurocognitive Screening Test to Aid in Identifying Cognitive Impairment and Dementia (BrainCheck): Cohort Study
JO  - JMIR Aging
SP  - e12615
VL  - 2
IS  - 1
KW  - dementia
KW  - neurocognitive tests
KW  - neurocognitive computerized assessment tools (NCAT)
KW  - mild cognitive impairment (MCI)
KW  - BrainCheck
KW  - digital testing
KW  - Alzheimer’s disease
KW  - electronic neurocognitive tools
KW  - computerized cognitive assessment
KW  - digital cognitive assessment
AB  - Background: The US population over the age of 65 is expected to double by the year 2050. Concordantly, the incidence of dementia is projected to increase. The subclinical stage of dementia begins years before signs and symptoms appear. Early detection of cognitive impairment and/or cognitive decline may allow for interventions to slow its progression. Furthermore, early detection may allow for implementation of care plans that may affect the quality of life of those affected and their caregivers. Objective: We sought to determine the accuracy and validity of BrainCheck Memory as a diagnostic aid for age-related cognitive impairment, as compared against physician diagnosis and other commonly used neurocognitive screening tests, including the Saint Louis University Mental Status (SLUMS) exam, the Mini-Mental State Examination (MMSE), and the Montreal Cognitive Assessment (MoCA). Methods: We tested 583 volunteers over the age of 49 from various community centers and living facilities in Houston, Texas. The volunteers were divided into five cohorts: a normative population and four comparison groups for the SLUMS exam, the MMSE, the MoCA, and physician diagnosis. Each comparison group completed their respective assessment and BrainCheck Memory. Results: A total of 398 subjects were included in the normative population. A total of 84 participants were in the SLUMS exam cohort, 51 in the MMSE cohort, 35 in the MoCA cohort, and 18 in the physician cohort. BrainCheck Memory assessments were significantly correlated to the SLUMS exam, with coefficients ranging from .5 to .7. Correlation coefficients for the MMSE and BrainCheck and the MoCA and BrainCheck were also significant. Of the 18 subjects evaluated by a physician, 9 (50%) were healthy, 6 (33%) were moderately impaired, and 3 (17%) were severely impaired. A significant difference was found between the severely and moderately impaired subjects and the healthy subjects (P=.02). We derived a BrainCheck Memory composite score that showed stronger correlations with the standard assessments as compared to the individual BrainCheck assessments. Receiver operating characteristic (ROC) curve analysis of this composite score found a sensitivity of 81% and a specificity of 94%. Conclusions: BrainCheck Memory provides a sensitive and specific metric for age-related cognitive impairment in older adults, with the advantages of a mobile, digital, and easy-to-use test. Trial Registration: ClinicalTrials.gov NCT03608722; https://clinicaltrials.gov/ct2/show/NCT03608722 (Archived by WebCite at http://www.webcitation.org/76JLoYUGf) 
SN  - 2561-7605
UR  - http://aging.jmir.org/2019/1/e12615/
UR  - https://doi.org/10.2196/12615
UR  - http://www.ncbi.nlm.nih.gov/pubmed/31518280
DO  - 10.2196/12615
ID  - info:doi/10.2196/12615
ER  -